An efficient method has been developed for the enantioselective synthesis of 2-phenyl-4,5,6,7-tetra-hydro-1H-indoles containing chiral substituents at the nitrogen atom. It is based on opening of the epoxide fragment of 1-phenylethynyl-7-oxabicyclo[4.1.0]heptane with chiral amines and/or amino acid esters followed by intramolecular, metal catalyzed cyclization.
A new approach has been developed for the synthesis of N-alkylpyrroles with a chiral substituent at the nitrogen atom by the Paal-Knorr reaction using esters of amino acids as the source of chirality.
м в обрезкова合作论文数2A I Omel'chenko合作论文数2
Andreev Ivan A合作论文数2Marina a Yurovskaya合作论文数2Alexander V. Kurkin合作论文数Faculty of Chemistry, Lomonosov Moscow State University2
Emil N Sobol合作论文数Beckman Laser Institute, University of California, Irvine;Medical Clinic, University of California, Irvine;Arcuo Medical Inc2
Olga I Baum合作论文数Russian Academy of Sciences Institute of Laser and Information Technologies Troitsk2Valery Lunin合作论文数Chemistry Department, Lomonosov Moscow State University1G. M. Belov合作论文数1
