There is now evidence of certain structural and functional changes in the endometrium that may be etiological factors affecting the reproductive system health. Endometrial hypoplasia and alter-ations in uterine hemodynamics may cause implantation failure. Because thin endometrium is associated with infertility, early miscarriage and difficulty of treating, further search and use of new therapeutic methods designed on the basis of domestic state-of-the-art technologies is relevant. Effectiveness of intracavitary photodynamic therapy (PDT) for patients with thin endometrium was investigated. Fifty patients at the age of 35.4+/-3.3 years with established diagnoses of thin endometrium and infertility were included in the study. All patients were given PDT. Before the treatment the photosensitiser “Photoditazine” was injected intracavitary in the II phase of the menstrual cycle. For irradiation of the uterine cavity the medical apparatus “LAMI” providing laser radiation with wavelength of 660 nm, was used. To distribute evenly the light in the uterine cavity, intrauterine cylinder optical fiber diffuser (OFD «KOVB-660») was used. The average laser power density was 0.05+/-0.02 W/cm2, energy density 36.7+/-5.9 J/cm2, laser exposure time 11.7+/-2.25 min. We found that the use of intracavitary PDT for thin endometrium allows to correct the menstrual cycle, to achieve long-lasting clinical effect, to regenerate the thickness and 3-layer structure of the endometrium, to increase the percentage of recognised pregnancies and to reduce the risk of pregnancy complications.

Dystrophic diseases of the vulva (DDV) are a group of diseases that have not been fully studied and are characterized by pain, itching, dyspareunia, dysuria, which significantly reduce the quality of life of patients, leading to vegetative-vascular and neurological disorders. Despite many different approaches, the problem of treating vulvar DDV remains unresolved, and among clinicians there is no single approach to treatment, which was the basis for studying the effectiveness of photodynamic therapy (PDT) with local application of a photosensitizer in patients with DDV. As part of the study, 35 patients with DDV were examined and treated. REVIXAN-DERMA gel was used as a photosensitizer, irradiation of the vulva was carried out using a medical laser device "LAMI" with a wavelength of 660 nm. One month after PDT of the vulva, we noted a clinical recovery in 70% of patients (no complaints), a normal vulvoscopic picture was observed in 60% of patients – epithelialization of cracks and erosions, restoration of the thickness of the epithelium, restoration of normal skin pattern, in the remaining 40% patients – epithelization of cracks and erosions, a decrease in the area of damage, restoration of the thickness of the epithelium was noted, in 70% of patients the cytogram was within the normal range, cells with signs of intraepithelial changes and malignancy were not found, in 30% of patients – a small number of horny scales, cells with signs of intraepithelial changes and malignancy were not found. During the PDT procedure of the vulva, no complications or side effects were registered. Thus, the results of the study after the use of PDT of the vulva with local application of the photosensitizer REVIXAN-DERMA gel indicate the effectiveness, safety and prospects of the method in the treatment of degenerative diseases of the vulva.

Фотодинамическая репаративная регенерация эндометрия при бесплодии, обусловленном хроническим эндометритомКацалап С.Н