This paper discussed the results of 2500 CSF-shunting operations in children with hydrocephalus different etiology. The authors used clinico-statical and mathematical analysis. They performed 11 of more informative indications which totally given the prognosic iduction of Suppurative infection complications. These indications included: Child age, etiology of hydrocephalus, the degree and nature of the hydrocephalus, pathology of pregnancy and childbirth, disordar of child development, weight lossing, hemostasis conditions, cerebrospinal fluid hyperalbuminosis, long-term of operative intervention and other indications. The infection complications frequency in dependented of amount the above indications. The negative amount, if the infection complications not more than 2 percent, when indications became totally (10 and more) that means positive evaluation and the frequency of infection complications appeared 83 percent of all patients. Finally the authors performed prevention of shunt infections which could be reduce the frequency of suppurative infection complications during CSF-shunting operations in children from 5 percent to 1,8 percent.