随着互联网科技的发展,大学生对手机、电脑等电子产品的依赖程度越来越高,加之大学学业任务越来越重,导致当代大学生高低肩、脊柱侧弯、圆肩等不良体态检出率升高,如果不施加必要的干预措施,会进一步影响大学生的身体健康状况和工作学习状态.本文对大学生存在的主要不良体态情况及造成的因素、干预治疗情况进行概述,为改善大学生不良体态情况提供参考.
结肠癌、直肠癌传统上是西方富裕国家最常见的恶性疾病,在过去几十年来,世界格局发生了变化,随着亚洲发展中国家的经济发展,结肠癌、直肠癌发病率急剧上升.到2030 年,全球结肠癌、直肠癌负担预计将增加60 ％,新增病例将超过220 万,死亡病例将超过110万[1].结直肠癌是一种高度侵袭性的癌症,许多病人死于此疾病,该病已成为中国第5 位癌症相关死亡的主要原因[2].结直肠癌的发病机制尚不清楚,但究其病因是多因素、内部和外部因素共同所致.基因多态性与结直肠癌的相关性有助于预测病程并采取预防措施,确定特定药物治疗的潜在目标[3].为提高病人的存活率,新的生物标记物在结肠癌、直肠癌诊断或预后的应用十分重要[4].细胞极性对组织稳态至关重要,细胞的顶端-基底极性破坏,开启和推动癌症多种类型的进展.维持细胞极性的常见分子有 E -cadherin 和Crumbs3等.维持细胞组织结构和生理功能的细胞外基质蛋白有Collagen type I (Col-I)和Hyaluroni-dase-1 (Hyal-1 ).实体瘤与周围微环境协同,促进肿瘤生长和转移.因此,研究肿瘤细胞和其微环境中的组件可以阐明发病机制,提供更多癌症早期诊断和预防的有效方法.
目的 分析依达拉奉对急性脑梗死患者氧自由基的清除效果及神经功能的影响.方法 选取我院2015年4月到2017年3月收治的80例急性脑梗死患者,使用单盲法将其分为两组:研究组和对照组,每组40例,研究组患者给予依达拉奉进行治疗,对照组患者给予常规治疗,对比两组患者的神经功能缺损评分(ESS)、超氧化物歧化酶(SOD)、血清丙二醛(MDA).结果 研究组患者的神经功能缺损评分、超氧化物歧化酶、血清丙二醛显著好于对照组,差异有统计学意义(P<0.05).结论 依拉奉对急性脑梗死患者氧自由基的清除效果较好,改善患者的神经功能,值得临床推广.
Objective To investigate the change and its relative factors of level of serum cystatin C in patients with cerebral infarction, and to explore the role of cystatin C in the initiation of acute cerebral infarction. Methods Blood pressure,lipid, cystatin C,CRP and IMT were measured among 61 cerebral infarction patients and 58 patients without cerebral infarction(control subjects). IMT was measured through ultrasonography. The correlation between serum cystatin C and its relative factors were analyzied by pearson linear correlation and multiple stepwise regression analysis.Results The serum cystatin C levels in patients with cerebral infarction was (0.83±0.45)mg/L, higher than that of the control subjects (0.68±0.19) mg/L (P<0.05). Serum cystatin C level was positively associated with CRP, IMT and LDL-C (r=0.653,P<0.001,r=0.556, P<0.001,r=0.266,P=0.038), and negatively associated with HDL-C (r=-0.253,P=0.049), and unassociated with other factors. Multiple stepwise regression analysis showed that CRP and IMT were independent association factors in inlfuencing serum cystatin C levels.Conclusion Serum cystatin C level was significantly elevated in cerebral infarction patients,Serum cystatin C was associated with inflammation, lipid metabolism and atherosclerosis.
Objective To evaluate the correlation between serum visfatin and cognitive disorder after acute cerebral infarction. Methods Through the ElLISA method for the detection of 88 cases of patients with acute cerebral infarction and 84 cases of healthy person serum fat hormone levels, and visfatin levels in two groups were compared by the Montreal cognitive assessment scale in the patients with cerebral infarction (CI) test, the cerebral infarction patients were divided into non cognitive impairment group and cognitive impairment group, and visfatin levels. Results The level of serum cholesterol in patients with cerebral infarction was significantly higher than that in the cognitive impairment group. Conclusion The relationship between serum lipid levels and cognitive impairment in patients with acute cerebral infarction.
Objective To investigate the correlation between lipid metabolic disorders and risk factors of cerebral infarction in young and middle-aged patients.Methods 40 patients with cerebral infarction in our hospital were selected as the experimental group, treated time in March 2013 to April 2014, while the other patients were selected as the control group, the three groups were compared with two groups of 40 groups of HDL-C, total cholesterol, LDL-C, A-I, apolipoprotein B100, apolipoprotein and lipoprotein (a).Results In the experimental group and the control group, there were signiifcant differences in the contents of three glycerol, total cholesterol, HDL-C, LDL-C , apolipoprotein A-I, apolipoprotein B100 and lipoprotein (a) (P<0.05), the difference was statistically significant. Conclusion Lipid metabolic disorder is a risk factor for cerebral infarction in young and middle-aged patients with cerebral infarction.
目的 探讨急性脑梗死患者进行早期康复治疗的临床效果.方法 94例急性脑梗死患者,随机分为常规治疗组和早期康复组,各47例.常规治疗组患者进行常规治疗,早期康复治疗组患者在常规治疗的基础上进行早期康复治疗干预,对比两组患者的康复效果.结果 早期康复组的综合治疗效果明显优于常规治疗组,差异有统计学意义(P＜0.05).结论 在临床治疗过程中,在常规治疗基础上加入早期康复治疗能够大大优化整体的治疗效果,值得应用和推广.
Objective To investigate the change and its correlation factors of serum level of leptin in patients with cerebral infarction(CI).Method Body weight,waist circumference,blood pressure and the levels of glucose lipids,uric acid,leptin,C-reactive protein(CRP) were measured in 30 cerebral infarction patients(CI group) and 30 patients without cerebral infarction(control group).The intimate-media thickness(IMT) of carotid artery was measured with ultrasonography.The correlation factors which influnce the serum leptin level in CI patients were analyzied by pearson linear correlation and multiple stepwise regression analysis.Results The systolic pressure,diastolic pressure,waist circumference,the IMT of carotid artery and the levels of CRP,leptin,low density lipoprotein(LDL),total cholesterol in CI group were significantly higher than those in control group(P0.05-0.01),while the level of high density lipoprotein(HDL) was significantly lower than that in control group(P0.01).The correlation analyies showed that the level of serum leptin was positively correlated with CRP,LDL and IMT(r=0.530,r=0.372,r=0.562;P0.05-0.01),and negativly correlated with HDL(r=-0.364,P0.05).Multiple stepwise regression analysis showed that CRP and IMT were independent association factors in influencing serum leptin level(P0.05-0.01).Conclusions The serum level of leptin is significantly increased in CI patients.It is associated with inflammation,lipid metabolism and atherosclerosis.
