An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

The search for new tuberculostatics is an important task for medicinal chemistry. A series of new O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes were synthesized and tested in vitro for antituberculosis activity. The synthesis of the target substances consists of 3 – 4 steps. In the first step, β-(4-phenylpiperazin1-yl)propionitrile was obtained in 79% yield; the second step yields β-(4-phenylpiperazin-1-yl)propioamidoxime in 75% yield. Subsequent aroylation of this amidoxime by substituted benzoic acid chlorides in the presence of Et3N leads to the target O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes in 61 – 93% yields. Hydrochlorides of the O-aroylated products were obtained in 72 – 94% yields by the action of ethereal HCl on solutions of the bases. PMR spectra of hydrochlorides of the O-aroylated products show evidence of slow inversion of the heterocycle at the β-position and coordination of HCl at the N1 atom of the 4-phenylpiperazine fragment. Some bases and hydrochlorides of O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes exhibited interesting antituberculosis properties when tested in vitro on sensitive, resistant, and multi-drug resistant strains of M. tuberculosis.

Search for new tuberculostatics is an important task for medicinal chemistry. A series of new O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes were synthesized and tested for antituberculous activity in vitro. The synthesis of the target substances consists of 3 - 4 stages. At the first stage, β-(4-phenylpiperazin-1-yl)propionitrile was obtained with a yield of 79%; the second stage yields β-(4-phenylpiperazin-1-yl)propioamidoxime at an amount of 75%. The subsequent aroylation of this amidoxime by substituted benzoic acid chlorides in the presence of Et3N leads to the target O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes with a yield of 61 - 93%. Hydrochlorides of O-aroylated products were obtained with a yield of 72 - 94% by the action of ethereal HCl on the base solutions. 1H NMR spectra of hydrochlorides of O-aroylated products show evidence of a slow inversion of heterocycle at β-position and the coordination of HCl molecule at N1 atom of 4-phenylpiperazine fragment. Some bases and hydrochlorides of O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes exhibited interesting antituberculous properties when tested in vitro on sensitive, stable, and multi-drug-resistant strains of M. tuberculosis.

The acid hydrolysis of a series of 5-aryl-3-(β-thiomorpholinoethyl)-1,2,4-oxadiazoles gave substituted benzoic acids and 2-amino-8-thia-1-aza-5-azoniaspiro[4.5]dec-1-ene chloride hydrate, whose structure was demonstrated by spectral methods and X-ray diffraction structural analysis.