The study of 581 patients with multiple primary malignant neoplasms of reproductive system including their genealogical data revealed that the risk of developing malignancies significantly increases in the presence of congenital defects of mismatch repair system. Mutations in mismatch repair genes (MSH2, MLH1 and MSH6) were detected in patients with multiple primary malignant tumors of the colon and reproductive system in 13 (37%) observations. It is feasible to perform DNA-diagnosis in patients with multiple primary cancers of the colon and endometrium starting with identification of mutation inMSH6 gene. All women with colorectal cancer, especially in cases where mutations in genes of mismatch repair system are present, should undergo simultaneous preventive surgery during preand menopause periods: hysterosalpingo-oophorectomy. The decision regarding the greater omentum should be based on each particular situation.

Up to date the question about the possibilities of medical and social examination and rehabilitation of the vulva appears to be rather difficult because of the small number of studies examining the psychosomatic status, for the rehabilitation and social integration of this group of patients.

Up to date the question about the possibilities of medical and social examination and rehabilitation of the vulva appears to be rather difficult because of the small number of studies examining the psychosomatic status, for the rehabilitation and social integration of this group of patients.

A 5-year survival of patients with Stage III colon cancer with prophylactic panhysterectomy in anamnesis was 83.3%, significantly higher than that of patients with Stage III colon cancer without panhysterectomy (69.3%) and than in colon cancer patients with metachronous ovarian metastases (42%). In families of patients with primary multiple malignant tumors (PMMT) of colon, endometrium and/or ovaries as well as in cases of accumulation in the same family of solitary tumors of the above locations it is necessary to carry out genetic testing to identify mutations in genes MSH2, MLH1, MSH6. Carriers of mutations in genes of mismatch repair MSH2, MLH1, MSH6 should be assumed to the high-risk group for the development of malignancies both PMMT of colon and organs of the female reproductive system and solitary tumors of the above locations. All women suffering from colon cancer, especially in the presence of mutations in genes of mismatch repair, in pre- and menopause should be undergone simultaneous prophylactic surgery: panhysterectomy. The question about the greater omentum should be decided situationally.

A major focus of the population health prevention are examinations carried out by the state, society and health. This is especially true for those branches of medicine, with high levels of morbidity and mortality such as oncology. The basic principles of clinical examination used in oncogynaecology are described in the paper.

A major focus of the population health prevention are examinations carried out by the state, society and health. This is especially true for those branches of medicine, with high levels of morbidity and mortality such as oncology. The basic principles of clinical examination used in oncogynaecology are described in the paper.

A state-, society-, public health-run follow-up of the population is one of the basic areas of disease prevention. This is particularly important for medicine sections with high morbidity and mortality rates, i. e. for oncology. The paper indicates the basic follow-up principles used in gynecological oncology.

Complex measurements of tumor markers help to improve the diagnosis of multiple primary neoplasms (MPN) significantly. For breast- ovarian MPN CA-125 was increased in 92.6 % and CA-153 — in 81.6 %. In patients with ovarian-colorectal MPN CA-125 was increased in 79.0 % and carcinoembryonic antigen — in 90.0 %.

The research conducted the first comprehensive studv of the methvlation status of tumor suppressor genes RASSF1A, RARB2 and SEMA3B in breast and ovarian carcinoma tissue samples, as well as in adjacent histologically normal tissue. For the first time it was found out that abnormal methylation of RASSF1A gene promoter region could be detected at the preclinical stage of breast and ovarian cancer, that would help to use this method in clinical practice as a noninvasive technique for early diagnosis.

The main strategy of reproductive help to oncological patients before antitumor treatment is based on the thesis Freezing everything that can be frozen. This strategy doesn‘t guaranty but gives hope. The main strategy of helping patients, who have already received antitumor treatment and didn’t use cryopreservation treatment, is the use of donor ovum, spermatozoon, embryos and surrogate mother.

There are some peculiarities of rehabilitation care among patients with vulva cancerous growth. Finding ways to solve this problem is still relevant

Treatment and rehabilitation of elderly patients are very often complicated by combined pathology. Chronic diseases, absence of acute clinical picture, pharmacological pathomorphosis, simultaneous or consecutive multi-causal monosymptomatology, alternating pharmacokinetics and pharmacodynamics of drugs condition the development and introduction of new forms and methods of complex rehabilitation into practice.

Social rehabilitation in patients who have been treated for malignancies of different sites and stages becomes a particularly urgent problem today and its solution is one of the promising areas of oncology. The important stage of this rehabilitation that seems to us is to maintain or recover their reproductive and sexual function, which becomes possible due to the use of current reproductive technologies in different cancer situations.