Patients with chronic prostatitis alone and in combination with prostatic adenoma have changes in the activity of the complement system, neutrophil function and content of pro- and anti-inflammatory cytokines. Abnormal representation of the proteins of the red cell membrane in patients with prostatic diseases affects structural and functional activity of erythrocytes in these patients. Dynamic changes in immune status of patients with chronic prostatitis and prostatic adenoma correlate with changes in functional red cell activity. This fact helps better understanding of pathogenesis of chronic prostatitis and prostatic adenoma.

Maintenance changes pro-inflammatory and anti-inflammatory cytokines at children with appendicular peritonitis before operative treatment and in the postoperative period are established. Interrelations of changes of laboratory and clinical and laboratory indices at children with appendicular peritonitis are defined. Indices for assessing state severity and treatment efficiency at children with appendicular peritonitis are determined.

The aim of the study was detection of local and systemic changes in the complement system in patients with chronic abacterial prostatitis (CAP) and chronic bacterial prostatitis (CBP) and to assess a relevant corrective efficacy of the hardware and software complex Andro-Gin (KAP-ELM-01 Andro-Gin). Before treatment, blood plasma of CAP patients contained elevated concentrations of all studied components of the compliment system and factor H but subnormal concentration of C1-inhibitor. Locally, all the compliment indices were high including C1-inhibitor and factor H except component C5. Initial blood plasma compliment fractions in CBP patients were elevated but regulatory proteins concentrations were low. Local compliment components C3, C4, C5 and C5a and factor H were significantly higher. Standard treatment of CAP partially corrected the level of C3, C3a, C4 components, locally normalized concentration of C3 component and corrected C4 component, while in CBP standard treatment normalized concentration of C3 component and reduced C3a, C4, C5 and C5a components, locally normalized the levels of C3, C4 components, corrected concentration of C3a, C5, C5a components, raised regulatory factors. Combination of the standard treatment with Andro-Gin unit compared to standard treatment alone, in CAP corrected plasma concentrations of C3, C3a, C4 compliment components and significantly raised levels of regulatory factors, locally--partially normalized the level of factor H. In CBP additional use of Andro-Gin more significantly improved concentrations of C3a and C5a components , locally--C5a component, raised significantly concentration of regulatory factors C1-inhibitor and factor H. Thus, KAP-ELM-01 Andro-Gin administration in CAP and CBP patients promotes more effective correction of systemic and local disorders in the compliment system, the improvement being more pronounced in CBP.

Patients with prostatic adenoma combined with chronic prostatitis were found to have abnormal content of proteins in peripheral blood erythrocytic membrane, erythrocytic sorption, concentration of nitric oxide stable metabolites, endotheline-1 and lipid peroxidation products in blood plasma before and after transurethral resection of the prostate. Different dosage forms of the drug longidase were tested for efficacy in correction of impairment of structural and functional properties of erythrocytes, endothelial dysfunction and lipid peroxidation in the above patients.

Под постоянным наблюдением находилось 82 пациента с острым панкреатитом (40 пациентов с билиарным и 42 больных с небилиарным острым панкреатитом), проходивших стационарное лечение в МУЗ «Городская клиническая больница №4» г. Курска с 2008 по 2011 г. В работе представлены данные о нарушениях структурно-функциональных свойств мембраны эритроцитов у больных острым панкреатитом билиарной и небилиарной этиологии до и после традиционной терапии. Определена недостаточная эффективность использования традиционной комплексной терапии у больных острым панкреатитом и обоснована необходимость применения дополнительно лонгидазы, гипоксена и эссенциале в работе профильных лечебных и профилактических учреждений.

According to the etiology of acute pancreatitis, the authors identified the most common phenotypes of superficial antigens of peritoneal macrophages: CD14(+) CD25(-)CD64(-)HLA-DR(-) in acute biliary pancreatitis, CD14(+) CD25(+)CD64(+)HLA-DR(+) in nonbiliary pancreatitis; moreover, all the patients were found to have increased expression of early (CD25+) and late (HLA-DR+) markers of cell activation. A comparative study was conducted and the most informative tools to evaluate the adhesive, cytokine-producing, phagocytic, and oxygen-dependent activities of peritoneal macrophages were recognized.

В условиях острого билиарного, больше при небилиарном панкреатите, установлены изменения структурно-функциональных свойств эритроцитов, свидетельствующие об уменьшении прочности и деформируемости эритроцитарной мембраны, снижении ее микровязкости и проницаемости. Выявлено повышение общей сорбционной способности эритроцитов, интенсификация липолитических процессов и снижение метаболической активности. Проведенное лечение недостаточно корригирует нарушения белкового и липидного спектра мембран эритроцитов при остром билиарном и в еще меньшей степени при остром небилиарном панкреатите.

Changes of membrane protein content and sorption properties of erythrocytes have been revealed in patients with chronic bacterial and abacterial prostatitis before and after conventional treatment. The additional use of Andro-Gin program complex in those patients was proved to be effective for correction of structural and functional properties of red blood cells.

При хроническом абактериальном, в большей степени при бактериальном, простатите, на системном и местном уровне установлено повышение концентрации провоспалительных цитокинов, ИЛ-2, ИФγ, активация системы комплемента. Содержание противовоспалительных цитокинов и функциональная активность нейтрофилов периферической крови при абактериальном простатите на системном уровне не отличаются от показателей здоровых доноров, а при бактериальном простатите – снижаются. При хроническом бактериальном простатите, в большей степени абактериальном, повышается интенсивность процессов перекисного окисления липидов и изменяется активность антиоксидантных ферментов. Традиционное лечение частично нормализовало при хроническом бактериальном простатите, в меньшей степени при абактериальном, иммунные и оксидантные нарушения, что обосновывает применение дополнительных методов коррекции.