Myocardial infarction remains one of the leading causes of high cardiovascular mortality in Russia and in the world. Formation of aneurysm of the left ventricle (LV) and parietal thrombus is a common complication of this incident. Thrombus in the LV cavity is a threat for the development of thromboembolic syndrome that requires appointment of long-term therapy with indirect anticoagulants, which on the other hand are dangerous for the development of severe haemorrhagic complications. The risk of bleeding in such cases may increase simultaneously with the decrease ischemic stroke risk. The appointment and cancellation of indirect anticoagulants should, therefore, be done according to strict indications, however, traditional sero-scale echocardiography does not always make it possible to confirm or refute the diagnosis of thrombosis confidently. The “golden standard” for diagnosing LV thrombosis is magnetic resonance imaging (MRI). However, this technique is of high cost and is available only in highly specialized institutions, therefore, its implementation remains impossible in all situations difficult from the point of view of diagnosis. In doubtful cases, the use of ultra-sound technique “speckle tracking imaging” can help to avoid MRI appointment, showing the presence or absence of myocardial contractile tissue.

The aim of the research. To study the frequency and structure of cardiac conduction disorders (CCD) in the populationof Arctic. Materials and methods. There were examined 348 people of both sexes aged 20 years old and older, randomly selected. All participants performed an electrocardiogram and Holter ECG monitoring (HMEKG). Results. The most frequently registered an incomplete right bundle branch block (BPNPG), other blockades were rare. Conclusion. The inhabitants of the Arctic have incomplete BPNPG very often. Other disturbances of cardiac conduction (DCC) have mainly older age groups. In men more often than women was identified sinoatrial block (SAB) and atrioventricular block (AVB).

Aim. To investigate association between 9p21.3 locus single nucleotide polymorphisms (SNPs) and coronary atherosclerosis severity and long-term outcomes after percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI). Material and methods. A total of 255 Caucasian patients (211 male, 44 female; aged up to 65 years, on the average 52.56±7.98 years) with MI were recruited into the study from 01.01.2009 to 30.06.2010. All participants were included into the study after written informed consent. Genome DNA was extracted from leukocytes of venous blood by the phenol-chloroform extraction method. Two SNPs rs10757278 and rs1333049 (locus 9p21.3) were tested by real-time polymerase chain reaction (PCR) according to protocol (probes TaqMan, Applied Biosystems, 7900HT). The coronary angiograms were reviewed by independent angiographers who were blinded to the results of the genotyp- ing (Philips Allura Xper FD10). The total number of lesions, Gensini score and SYNTAX score were derived. Follow-up lasted two years. Results. Locus 9р21.3 genotypes CC rs1333049 and GG rs10757278 demonstrated a direct strong association with severity of coronary atheromatous burden (left main coro- nary artery stenosis, total number of lesions, Gensini score). There are not influence of locus 9p21.3 on mortality, recurrent MI, hospitalization due to unstable angina, repeated PCI, stroke during follow-up period (6, 12, 24 months). Frequency of the genotype СС rs1333049 among patients with recurrent MI was 20% (without recurrent MI — 27.4%; р=0.54); with hospitalization due to unstable angina — 27.5% (without hospitalization — 26.4%; р=0.82); with repeated PCI — 24.0% (without repeated PCI — 27.2%; р=0.97); among died patients — 29.8% (among survived ones — 26.4%; р=0.76). Frequencies of the genotype GG rs10757278 were similar: recurrent MI (yes — 18.8%; no — 26.4%; р=0.49); hospitalization due to unstable angina (yes — 28%; no — 25.3%; р=0.42); repeated PCI (yes — 23.7%; no — 26.3%; р=0.98); death (yes — 28.6%; no — 25%; р=0.51). Conclusion. Locus 9р21.3 genotypes CC rs1333049 and GG rs10757278 revealed significant association with severity of coronary atheromatous burden in patients with MI. There was no relationship between these genotypes of locus 9р21.3 SNPs and long-term PCI outcomes.

The aim of the research is to carry out differential diagnosis of essential hypertension of the first stage and neurocirculatory dystonia of hypertension type with the help of heart rate variability and ambulatory blood pressure monitoring. 56 patients with essential hypertension of the first stage and 25 patients with neurocirculatory dystonia of hypertension type were included in our research. All patients were directed from the regional military commissariats, from cardiological department of Krasnoyarsk municipal hospital. All patients were examined according to the following program: clinical examination, electrocardiography, echocardiography, cycle ergometry, ambulatory blood pressure monitoring (ABPM), heart rate variability (HRV). Results were processed using parametric and non-parametric methods of mathematical statistics and standard software Excel, Statistica 6. The data is presented as М±σ and Ме (Р25; Р75). According to ABPM data during the essential hypertension of the first stage unlike during the neurocirculatory dystonia of hypertension type there occur: significantly higher rating of mean systolic and diastolic blood pressure during the day, hypertensive time index, area index, normalized area index, index of measurement of systolic and diastolic arterial pressure during the day, mean systolic arterial pressure during the night, hypertensive time index, area index, normalized area index, index of measurement of systolic pressure during the night, mean arterial pressure minimum during the day, mean arterial pressure during the day, mean arterial pressure maximum during the day, mean pulse arterial pressure during the day, mean arterial pressure minimum during the night. Moreover, the established differences in the characteristics such as asymmetry and capacity of the high frequency were revealed in our groups using HRV.

The paper presents diagnostics criteria of hypertension I stage and neurodiscirculatory dystonia by hypertension type in men on the age 18-25 by daily arterial blood pressure monitoring.