Background.The prevalence of various allergic diseases has increased worldwide in recent decades. Allergy diagnosis in children should be economically optimal and as sparing as possible, while ensuring the high quality of medical care.Objective.The aim of the study is to develop optimal algorithms for analysis of sensitization profile in children with allergy family history, or suspected allergy, or atopy phenotype.Methods.Complete examination of 153 children aged from 1 to 17 years 11 months was performed. Children were divided in 4 groups according to the presence and characteristics of complaints, the presence of allergic disease. Sensitization was determined via the “gold standard” of allergy diagnosis — the ImmunoCap method (Phadia, Sweden), and the results of skin testing.Results.97 (63.4%) children have shown sensitization to various allergens. We have revealed seasonal manifestation of allergy in children to various allergens: Fagales in 89-92% of cases, grasses in 68-72% of cases, weeds in 39-57% of cases. Complaints of all-year manifestations of allergic rhinitis were revealed in 24% of cases to cat dandruff, complaints of coughing and/or bronchospasm — in 100% of cases to birch pollen and in 35% of cases to house dust. The sensitization analysis has revealed strong correlations with confirmed statistical significance between pollen allergen sensitization classes in groups of different plants.Conclusion.Optimal algorithms for sensitization diagnosis in children living in Moscow agglomeration were developed according to the obtained results and revealed correlations.

Background. Anti-inflammatory therapy is used to achieve and maintain asthma control, as well as respiratory function indicators monitoring. Telemedicine technologies can be used for this purpose, and it became particularly essential during the COVID-19 pandemic.Objective. The aim of the study is to analyze efficacy of the mobile technology MedQuizBot for asthma monitoring, to estimate patient compliance to use such instruments of self-control via the bot and without it, and bot's functioning satisfaction.Methods. 6-month prospective observational comparative study in patients with asthma from 4 to 17 years old was conducted. All patients were divided into two groups: patients who have used MedQuizBot and patients who have used any other self-control tools. Patients had to enter peakflowmetry data daily and undergo asthma control tests monthly. Patients were able to communicate with their doctor remotely via the chat bot. Main study indicators: determining the efficacy of MedQuizBot in patients with asthma by estimating the compliance to self-control tools at using the bot. Secondary study indicators: estimation of patients satisfaction on using the MedQuizBot and determination of level of asthma control due to the obtained data results.Results. 41 patients have used MedQuizBot, 27 patients were in the control group. Patients who used the bot more often answered asthma control test questions. Patients over 12 years old have completed the asthma control test less often than young children: ACT was filled on average in 1.5 times, САСТ — 1.8 times. 51% of patients filled in data on peakflowmetry via the new technology, patients from control group did not start the picflowmetry diary. Patients under 12 years old, who filled up the test with their parents, has entered picflowmetry data 7 times more often than adolescents. The asthma was under control in 70% of patients. The data was entered into the system 2.5 times more often during the lockdown period due to COVID-19 pandemic and during the tree flowering season in comparison to other periods of2020. Patients noted the usability of the MedQuizBot and agreed to use it in future.Conclusion. MedQuizBot is effective in achieving asthma control mainly during the period of need — in case of insufficient control over the disease itself (exposure to pollen allergens, acute respiratory diseases), during the limitations in medical care availability.

Background: Children with allergic diseases, especially bronchial asthma, are in need of protection from acute respiratory infections, as anti-epidemic measures cannot prevent the spread of influenza; vaccination remains the best means of prevention. Another promising direction in the prevention of acute respiratory infections (ARI) can be immunomodulators of bacterial origin. Objective: Our aim was to study the use of immunomodulators for prevention of respiratory infections with children having allergic diseases. Methods. A comparative analysis of prophylactic efficiency of specific and nonspecific immunoprophylaxis of ARI with children having allergic diseases has been done during three epedemic seasons (2011–2014). Results. For immunization of 335 children aged 3–17 years having a variety of allergic diseases, vaccine (domestic and foreign) in combination with an immunomodulator, and without it have been used. With the help of vaccination, the number of cases of ARI during the whole observation period decreased significantly: 21 (6.3%) children did not have ARI,62 (18.5%) children had ARI once, 252 (75.2%) children — from 1–4 times in a year. Also, significant reduction of frequency of aggravation of the basic disease was observed in all treatment groups. Patients who received only immunomodulator, had significant reduction of both ARI and the basic disease (p <0,05). Conclusion. The use of vaccines in combination with an immunomodulator or without it fully protects children from flu and significantly (1.5 times) reduces prevalence of ARI.

Background and aims Congenital and hereditary diseases of respiratory system are often accompanied by nonspecific symptoms, that result in late diagnosis and time-lag therapy. In some cases, such diseases have symptoms, similar to asthma, so children are wrong diagnosed and do not receive appropriate treatment for a long time. Aim: to define the informative value of measurement of exhaled nitric oxide (FeNO) as a non-invasive screening method for patients with pathology of pulmonary system. Methods 598 children (from 4 to 17 y.o.) were examined at Scientific Centre of Children’s Health from 01.01.2012 to 11.06.2016. The level of FeNO was determined by portable hand held monitor using, unit ppb (parts per billion). Results 557 patients (93.14%) were diagnosed with asthma of different severity. Variation of level of FeNO depended on asthma severity and control. FeNO was normal or elevated (from 5 to 233 ppb). In 41 (6.8%) patients the level of FeNO was low (<5 ppb): 25 children (61%) with cystic fibrosis (CF), 5 (12%) with congenital lung malformations (CLM) and 11 (27%) with primary ciliary dyskinesia (PCD). The mean of FeNO level in children with CLM was 2,616±1,804, with CF: 3,27±3,07, with PCD: 0,88±0,53. FeNO level in children with PCD was lower than in children with CF (p<0.05). Conclusions The finding data indicate the possibility of using of FeNO level evaluation as a non-invasive screening method in the complex differential diagnostics of pulmonary system pathology in children.