Electrochemical fluorination (hereinafter: ECF) is a method to introduce fluorine into organic or inorganic substrate through some electrode reactions. The ECF method involves passing of a direct current through a solution of some initial organic substance in anhydrous hydrogen fluoride. J.Simons (USA) developed the most part the ECF method in early 1940th [1]. ECF provides replacement of all hydrogens by fluorines, saturation of triple or double C=C bonds and aromatic systems with fluorine, and fragmentation of carbon skeletons, while functional groups and heteroatoms available in the original molecule stay untouched. ECF demonstrates a number of advantages over other methods of synthesis of perfluorinated organic substances:

Products of electrochemical fluorination of tripropylamine and triallylamine were studied by gas chromatography-mass spectrometry and high-resolution 19F NMR spectroscopy. The use of these methods allowed identification of the structures and isomeric composition of components of the electrolysis products.

Electrochemical dimerization of hexafluoropropylene oxide dimer and trimer acids on SU-2000 glassy carbon, bulk platinum, and SU-2000 electrodes modified with platinum-group metals in acetonitrile in the presence of water was studied at various concentrations of the starting substance and different degrees of neutralization of the starting acid. Also, the possibility was examined of obtaining some perfluoropolyethers in a single process by cross-condensation of several starting perfluorocarboxylic acids, followed by separation of the products by physicochemical methods.

Glassy carbon, smooth platinum, and platinum-plated glassy carbon were tested as anode materials in electrochemical trifluoromethylation of ethylene. The reaction products were identified and specific features of the process were examined.

Electrochemical fluorination of benzotrifluoride in the presence of triallylamine as depolarizer was studied. The possibility of preparing perfluoromethylcyclohexane and its isomers with high current efficiency and substance yield in combination with perfluorinated tertiary amines was examined.

Doseand time-dependent induction of cytochrome P450 1a, 2b and 2c subfamilies by novel perfluorochemical compound (TBF) was investigated. It was shown that TBF significant increases Cyp2b and Cyp2c specific activities in mouse liver, whereas it has little if any effect on Cyp1a specific activities. Results of multiplex RT-PCR have shown that TBF administration leads to 7,5-fold increase of relative Cyp2b mRNA level. Thus, our results provide evidence to support the conclusion that TBF is novel inducer of Cyp2b in mouse liver and mechanism of induction occur through transcriptional activation of Cyp2b genes.