Analysis of the complex treatment efficiency was carried out for patients with pancreonecrosis who also underwent extracorporeal hemocorrection. Alterations in the morphofunctional condition of platelets was revealed and assessed during replacement plasmapheresis and semiprolonged hemofiltration at different stages of pathological process. The quantitative criteria were proposed for assessment of efferent therapy efficiency in patients with pancreonecrosis at the stages of enzymatic shock and suppurative complications.

Aim. To study the profile of IL-6 in the early postoperative period after kidney transplantation and the factors that affect concentration of this cytokine.Methods and results. 28 kidney recipients were included in the study. It has been found that in most patients after surgery IL-6 was released, and the absence of such a reaction was a poor prognostic sign. Rate of increasing of the concentration and form of its curve within the first postoperative day depended on the length of preservation, warm ischemia time, type of donor, and differed in recipients with normal and delayed initial graft function.Conclusion. Further study of the role of circulating factors in kidney transplantation would improve patient outcomes.

The data presented concern investigation of efficacy and validity of applying a half-extended hemofiltration in complex treatment of patients with surgical sepsis. Under observation there were 33 patients with multiple organ insufficiency against the background of the severe pyoseptic complications of abdominal cavity diseases. On the basis of morphometric data of circulating thrombocytes, criteria were established for estimation of endogenous intoxication severity and prognostication of the course of multiple organ insufficiency during extracorporeal therapy.

The article focuses on the results of the investigation of peripheral blood lymphocyte morphofunctional status in healthy volunteers and renal allograft recipients for early postoperative period. Working out noninvasive tests for diagnosis of acute renal allograft rejection based on the measuring of cell morphometric parameters by method of coherent phase microscopy (CPM). It was found out that the lymphocyte phase height was proportional cell image density and its geometrical thickness. Our results showed that the variations of immunocompetent cell morphometric indicants can be in advance the dynamics of blood creatine increasing and answer for early criteria of acute renal allograft rejection.

Results of clinical application of acute vital computer morphometry to diagnose acute rejection of renal allograft are presented. Patients with the end stage renal disease were observed in dynamics of the early post-operative period including recipients with satisfactory and stable function of renal allograft and those with acute allograft rejection confirmed by clinical and laboratory data. Criteria for the early diagnosis of allograft rejection were proposed on the basis of the morphofunctional condition monitoring of living lymphocytes of the peripheral blood.

The morphofunctional status of peripheral blood platelets from 16 recipients, 16 optimal and 16 marginal donors renal allograft were investigated by method of vital computer phase morphometry (phase-interference microscope "Cytoscan"). The abnormality of platelet hemostasis was found out in recipients and potential renal allograft donors. Such hemostasis damages can promote the thrombotic complications and failure of microcirculation in renal parenchymatous tissue.