According to the World Health Organization, as of 2020, annual infection with C. trachomatis, as register, 129 million people, with the highest incidence observed in group under the age of 25 years. Objective. The study of the pharmacological activity of meglumine acridone acetate and lysine acridone acetate, in the form of a solution for intramuscular administration, in a model of acute chlamydial infection with C. trachomatis in mice. Materials and methods. The studies were performed on 80 mice (male and female) of the DBA/2 line. Modeling of acute chlamydia in mice was carried out by intravenous administration of a live culture of C. trachomatis serovar D. A course (10 days) intramuscular administration of meglumine acridone acetate and lysine acridone acetate began on the 10th day of the experiment. Results. The study found that the administration of meglumine acridone acetate and lysine acridone acetate at doses of 46.4 mg/kg for 10 days in the acute phase of infection caused by C. trachomatis leads to positive dynamics in the clinical picture of the infectious process, weight gain in animals, and a decrease in the number of PCR-positive animals, the concentration of pro-inflammatory cytokines IL-1α and IL-6 and the values of the index of positivity of antibodies to C. trachomatis – IgM. Conclusion. The data obtained indicate the effectiveness of the use of meglumine acridone acetate and lysine acridone acetate in the treatment of infections caused by C. trachomatis. Key words: meglumine acridonacetate, lysine acridonacetate, acute chlamydial infection

Actin-binding proteins and, in particular, members of the actin-depolymerization factor (ADF)/cofilin family, are involved in the regulation of the actin cytoskeleton in response to various intracellular and extracellular signals. Recent studies point to the exceptional role of this group of proteins in the development and functioning of the nervous system. This review presents the latest data on the functions of cofilin in the cell and the signaling pathways involved in its regulation. Special attention is paid to studies of the relationship between cofilin and actin dynamics in such processes as the control of synaptic plasticity, apoptosis of neurons, and neuroinflammation. We show the molecular mechanisms of cofilin activation-inactivation and the specific structure of actin in nerve cells during neurodegeneration in the in vitro and in vivo models. We review new directions in the study of cofilin and related proteins as prognostic markers and therapeutic targets in the diagnosis and treatment of diseases of the nervous system.