The studies reported here confirmed the value of ultrasound tests in the differential diagnosis of various hearing disorders: otosclerosis, adhesive otitis media, Ménière's disease, and chronic purulent otitis media, as well as sensorineural deafness of various etiologies. A new compact and inexpensive device based on state-of-the-art components was developed to provide maximal convenience in carrying out the differential diagnosis of different forms of deafness using the phenomenon of ultrasound perception.

An electrophysical apparatus for combined electroporation and iontophoresis treatment of biological membranes is described. Estimates of cell viability in living tissue equivalents exposed to pulsed current with a dc offset are provided. The values of the electrophysical pulse characteristics compatible with the viability of cells in the living tissue equivalents have been determined. The obtained data suggest that these electrophysical parameters could be used for transportation of pharmaceutical compounds through an equivalent of the round window membrane of the cochlea. A technique of drug administration across biological barriers can be developed based on pulsed electric field equipment to enable drug delivery into the inner ear.

The paper deals with an electrophysical device for combined electroporative-iontophoretic effect on biological membranes. The experimental results on the influence of a pulsed current source with displacement on the viability of living tissue equivalents (LTE) cells are presented. There were obtained values ​​of pulse electrophysical parameters providing preservation of LTE cell vitality. According to the obtained data we suggest that such electrophysical parameters can be used for drugs delivery through the equivalent of the round window membrane and for creation in the future a technology for the administration of drugs through biological barriers with the possibility of their penetration into the inner ear using pulsed electrical installations.