Objective: to study the association of genetic polymorphisms of chemokines (+1931А/Т ССL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) with arterial pressure in patients with chronic glomerulonephritis.Materials and methods: the study group comprised 700 people, including 238 patients with chronic glomerulonephritis and 462 controls. When assessing the level of blood pressure, the patients were divided into three groups: with arterial pressure less than 140/90 mm Hg - 84 patients, with arterial pressure from 140/90 to 159/100 mm Hg - 96 patients with arterial pressure more than 160/110 mm Hg - 52 patients. Th e material for the study was DNA samples isolated from whole venous blood by the phenolchloroform extraction method. Th e analysis of the studied polymorphisms was carried out by the method of detection of TaqMan probes by means of real-time PCR.Results: it was found that a high level of diastolic blood pressure in patients with chronic glomerulonephritis is associated with the molecular-genetic markers GG and CG CCL2 (rs2857657) (p=0,014), the risk factor for the development of severe arterial hypertension during the disease is the allele A CXCL11 (rs4512021) (p=0,04, OR=1,65).Conclusion: new data on the involvement of A/G CXCL11 (rs4512021) and C/G CCL2 (rs2857657) polymorphisms of chemokine genes in the development of arterial hypertension in patients with chronic glomerulonephritis of the Central Chernozem Region of Russia have been revealed.

Research of polymorphism genes of vascular reactions AGT and ADRB2 at patients are resulted. Presence at patients chronic glomerulonephritis of genotypes -6GG and -6AG gene AGT is connected with the raised arterial pressure.

Research of polymorphism genes of vascular reactions AGT and ADRB2 at patients are resulted. Presence at patients chronic glomerulonephritis of genotypes -6GG and -6AG gene AGT is connected with the raised arterial pressure.

Studying two groups of patients with chronic glomerulonephritis has been carried out the patients without CGN and patients with CGN. It has been revealed that with the increase in degree of CGN the concentration of IGA grows and the contents of IgM and IgG are reduced. Based on the data on the concentration of antibodies the model of differential diagnostics of CGN with and without renal failure has been developed with accuracy of discrimination of the given groups 78.66%. The frequencies of genotypes of tumor necrosis factor α gene, tumor necrosis factor receptor of the 1 type gene, tumor necrosis factor β gene, the transforming growth factor and interleukin 9 gene in patients with chronic glomerulonephritis have been studied. The genetic markers of unfavourable course of chronic glomerulonephritis are revealed: allele A and genotype АА of tumor necrosis factor receptor of the 1 type gene associated with chronic renal failure.