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1Current Features of Diagnosing the Autoimmune Type of Chronic Spontaneous Urticaria in Clinical Practice

E.V. Burygina,Y.I. Kozlova,E.V. Frolova,A.E. Uchevatkina,O.V. Aak,L.V. Filippova, A.V. Melnikova,K.I. Raznatovsky,N.V. Vasilyeva,N.N. Klimko

2023Klinicheskaya dermatologiya i venerologiya（2023）

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2НОВЫЕ МЕТОДЫ В ДИАГНОСТИКЕ АУТОИММУННОЙ КРАПИВНИЦЫ

Е В Бурыгина,Я И Козлова,Е В Фролова,А Е Учеваткина,Л В Филиппова,О В Аак, А В Мельникова, М А Захваткина, Н В Васильева,Н Н Климко

2020Проблемы медицинской микологии

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3Features of Fungal Sensitization in Patients with Asthma and Cystic Fibrosis: the Results of a Prospective Study

Y I Kozlova,E V Frolova,Y V Borzova,A V Sobolev,E V Burygina,O V Aak, O A Nikitin, V D Kuznetsov, N

Background. To estimate the frequency of fungal sensitization and allergic bronchopulmonary aspergillosis in patients with asthma or cystic fibrosis. Methods. The study included 205 patients with asthma and 190 patients with cystic fibrosis. For detection of fungal sensitization specific IgE antibodies in the blood serum with «AllergoELISA-specific IgE» test system and biotinylated fungal allergens were determined. Mycological examination included microscopy and cultural study of respiratory biomaterials. According to the indications, a CAT scan of the chest was performed. Results. The incidence of fungal sensitization in patients with asthma was 35,6%, CI [29,1%; 42,6%], in patients with cystic fibrosis - 56,8% [49,5%; 64%]. In patients with severe asthma the main fungal allergens were Alternaria spp. (70%) and Aspergillus spp. (60%); in patients with cystic fibrosis: Candida spp. - 73%, Alternaria spp. - 34%, Aspergillus spp. - 27%. The incidence of allergic bronchopulmonary aspergillosis (ABPA) in patients with asthma was 5,3%, in patients with cystic fibrosis - 5,7%. Conclusion Early detection of ABPA in patients with asthma and cystic fibrosis is very important as it changes the therapeutic measures of patients’ management and prevents progression of bronchiectasis and respiratory failure. Determination of specific Aspergillus spp. IgE antibodies in vitro is a necessary stage of diagnosis of ABPA in patients at risk.

2018Russian Journal of Allergy（2018）

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4Influence of Antifungal Therapy on Immunological Parameters in Patients with Allergic Bronchopulmonary Aspergillosis

Y. I. Kozlova,N. N. Klimko,E. V. Frolova,A. E. Uchevatkina,L. V. Filippova,E. V. Burygina,O. V. Aak,A. V. Sobolev

2017MYCOSES（2017）

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5Basophil activation test in the diagnosis of allergic bronchopulmonary aspergillosis

Y. I. Kozlova,E. V. Frolova,A. E. Uchevatkina,N. V. Bychkova,L. V. Filippova,N. I. Davydova,E. V. Burygina,N. N. Klimko

2017MYCOSES（2017）

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6Allergic Bronchopulmonar Aspergillosis in Asthmatic Patients

Y I Kozlova,A V Sobolev,E V Frolova,O V Aak,E V Burygina, N

Allergic bronchopulmonary aspergillosis (ABPA) is a caused by hypersensitivity to Aspergillus spp. antigens, is the lung disease, which occurs in patients with asthma or cystic fibrosis and is characterized by poor control of background disease and development of respiratory failure. According to experts opinion the number of patients with ABPA is about four million people in the world and 175 000 persons in Russian Federation. The clinical course improvement, prevention of progression and prophylaxis of bronchiectasis depend on timely and correct diagnosis of the disease. International Society of Human and Animal Mycology (ISHAM) formed a working group «ABPA in patients with asthma» for worldwide collaboration with physicians and researchers. The working group proposed new diagnostic criteria. This report presents a clinical case of ABPA in asthmatic patient. The diagnosis is established according criteria proposed by R. Agarwal et al., 2013.

2015Russian Journal of Allergy（2015）引用：2

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7Fungal Sensitization of Patients with Asthma in St. Petersburg

Y I Kozlova,E V Frolova,A V Sobolev,O V Aak,A E Uchevatkina,L V Filippova,E V Burygina, N

Background. Fungal sensitization is associated with severe uncontrolled asthma. Connections of specific, micromycetes and fungal allergens with disease development and immunopathogenesis of asthma with fungal sensitization are not well understood. Methods. The study included 120 patients with different grades of asthma severity. Results. Fungal sensitization was detected in 48 patients with asthma (40%). Severe course of asthma with fungal sensitization was identified in 7 patients (14,6%). The main fungal allergens in patients with severe asthma were Alternaria spp. and Aspergillus spp., in patients with mild and moderate course of disease - Aspergillus spp. and Penicillium spp. Increasing of serum total IgE and enhancing the ability of blood cells to produce IL2 and IFN-y in patients with bronchial asthma with fungal sensitization were revealed. The obtained results indicated the important role of Th1 along with Th2 cells in the development of immunopathological process in asthma patients withfungal sensitization. Conclusion. Further research is necessary for determination of clinical and immunological criteria of severe asthma with fungal sensitization and study of the effectiveness of antimycotic therapy.

2015Russian Journal of Allergy（2015）

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8Immunological Features in Patients with Asthma and Fungal Sensitization