In order to develop and to test the technique of restoration/preservation of fertility in prostate tuberculosis patients and to evaluate its e_ciency the open prospective comparative randomized trial was conducted which included 72 prostate tuberculosis patients. The patients were divided into 2 groups: the main group (49 patients) who had standard etiotropic treatment with sperm-protecting therapy, including selzinc plus and chorionic gonadotropic hormone and the comparison group (23 persons), who received etiotropic treatment only. Anti-tuberculosis treatment provided the negative impact on the ejaculate in prostate tuberculosis patients: two month treatment with TB drugs promoted the reduction of sperm number by 23.9% and the number pf actively moving sperms reduced by 10.6%, and the number of normal sperms reduced by 32.3%. The administration of sperm-protecting therapy increased the number of sperms by 47.8%, the actively moving forms of sperms (totally Group A and B) – by 40.5%, and the forms of normal sperms – by 41.9%.

INTRODUCTIONMetabolic syndrome (MS) negatively affects the quality of ejaculate, especially in patients with chronic prostatitis.MATERIAL AND METHODSTo determine the effect of metabolic syndrome on semen parameters in patients with tuberculosis of the prostate (TP), a study of 72 patients with prostatic tuberculosis was conducted. MS was diagnosed when at least three of the five following medical conditions were found: central obesity, elevated levels of plasma triglycerides, high blood pressure, hyperglycemia and decreased levels of high-density lipoproteins. Semen parameters were compared in patients with tuberculosis of the prostate with and without MS.RESULTS41% of patients with prostatic tuberculosis had metabolic syndrome, which was associated with a 1.5, 1.4 and 2.5 fold decreases in the number of sperm, sperm concentration, and the number of normal sperm forms, respectively.CONCLUSIONSThese findings provide the rationale for developing specific therapies aimed at restoring ejaculate fertility in patients with prostatic tuberculosis, considering that almost a half of them have MS.

INTRODUCTION:Genital tuberculosis impairs male reproductive function. Given that tuberculosis of the prostate has been found at autopsy in 77% of men who died of tuberculosis of all locations, the problem is highly relevant.AIM:To develop and test a method of restoring/preserving fertility in patients with prostatic tuberculosis and to evaluate its effectiveness.MATERIAL AND METHODS:TThis is an open, prospective, comparative, randomized study, comprising 72 patients with prostatic tuberculosis. Patients of the main group (n=49) received standard TB treatment in combination with pathogenetic spermatoprotective therapy including zinc and selenium based dietary supplement and chorionic gonadotropin. The men in the comparison group (n=23) were treated only with etiotropic TB therapy.RESULTS:TB treatment had a negative effect on the ejaculate: in the comparison group a two-month course of drug therapy resulted in a decrease in sperm cell count by 23.9%, in the number of actively motile sperm cells by 10.6% and in the number of normal sperm cells by 32.3%. Pathogenetic spermatoprotective therapy increased the sperm cell count by 47.8%, the number of active mobile forms of spermatozoa (total of A and B) by 40.5%, the number of normal sperm cells by 41.9%.CONCLUSIONS:Spermatoprotective therapy, including human chorionic gonadotropin and zinc and selenium based dietary supplement significantly increases the ejaculate fertility.

INTRODUCTION:Modern TB patient has lost the physical appearance (habitus phtisicus) typical for the previous years. Moreover, patients with different tuberculosis localizations also have different anthropomorphic characteristics.MATERIAL AND METHODS:To determine anthropomorphic characteristics of patients with tuberculosis of the prostate, several parameters were compared between 95 male patients with pulmonary tuberculosis and 49 patients with prostatic tuberculosis.RESULTS:Compared to pulmonary tuberculosis patients, patients with prostatic tuberculosis were significantly more likely to be overweight and have greater waist circumference. Among patients with pulmonary tuberculosis, there were significantly more people of short or very tall stature, while patients with prostatic tuberculosis, on the contrary, were significantly more likely to be of average height (166-180 cm).CONCLUSIONS:The findings regarding body structure of a patient with tuberculosis of the prostate (fat stocky man) could possibly reflect the presence of the metabolic syndrome that may account for the greater susceptibility to urogenital infections.

Open prospective comparative randomized study was conducted in order to evaluate e`ciency and safety of various techniques of administration of rifampycin, anti-tuberculosis drug, into the prostate. 36 patients at the age from 32 to 60 years old (38,9 years old on the average) were randomly selected into three groups, 12 patients in each group. All of them were treated with rifampicin in the dose of 0.6 g on the daily basis. The 1st group took the medication per os, the second group received intravenous injections, and the third group received the medication per rectum for 5 days. The method which less inhibited the quality and quantity of ejaculate was considered the safest. The e`ciency was evaluated by the reduction of pyospermia. The confidence of diwerences was evaluated by criteria of χ 2 (Statistica 6). The most e`cient method of anti-tuberculosis drug administration for prostate tuberculosis patients is the intravenous drip infusion and administration of curative mixture in micro-clysis, the diwerence between these two techniques is insignificant. Per os intake rifampycin is confidently less e`cient compared to intravenous and per rectum administration techniques. The safest method regarding morphology, motility, quantity and concentration of sperms is per os and per rectum administration of rifampicin. Thus the best combination of e`ciency and safety for anti-tuberculosis drugs administration for prostate tuberculosis patients is introduction of curative combination of drugs in micro-clysis.

Периферическая лимфатическая система инфицируется микобактерией туберкулеза (МБТ) во время лимфогенной диссеминации, но не у всех пациентов развивается клинически документированное поражение лимфоузлов.

In order to analyze the structure of urogenital tuberculosis, retrospective analysis of medical records of 131 patients with newly diagnosed urogenital tuberculosis observed in the Novosibirsk Regional TB Dispensary from 2009 to 2011 was performed. The renal tuberculosis is main form in the structure is urotuberculosis, detected in 75% of patients, and widespread destructive forms of the disease were diagnosed in more than half of cases. Isolated nephrotuberculosis was more often diagnosed in women--56.8%. 15.9% of patients had asymptomatic nephrotuberculosis; one-third of patients complained of pain in the lumbar region and frequent painful urination (35.2 and 39.8%, respectively); symptoms of intoxication were present in 17% of patients, renal colic--in 9.1%, and gross hematuria--in 7.9% of patients. Mycobacteriuria in isolated nephrotuberculosis was detected in 31.8% of cases. Acute tuberculous orchiepididymitis developed in 35.7% of patients, hemospermia was observed in 7.1% of patients, dysuria was in 35.7% of patients. The pain in the perineum, frequent painful urination (both by 31.6%), hemospermia (26.3%) were main complaints in prostate tuberculosis. Mycobacteria was detected in 10.5% of cases. It was found that urogenital tuberculosis has no pathognomonic symptoms; the most alarming manifestations include long-term dysuria, hematuria, hemospermia.