Deep infiltrative endometriosis is a common disease affecting young socially active women. The urgency of the problem of deep infiltrative endometriosis is due to the complexity of diagnosis, the lack of a unified classification of the disease and, as a consequence, the lack of a unified strategy for the management of such patients. The importance of infiltrative endometriosis is emphasized by the fact that, as a rule, it is a multidisciplinary surgical intervention of high complexity, a feature of which is often the inability to determine the final volume of surgical intervention at the preoperative stage. In the structure of surgical interventions, surgeries for deep infiltrative endometriosis have a relatively high percentage of complications and in the context of operations that improve the quality of life, have many controversial aspects. Over the years of laparoscopic surgery, the approach to surgical interventions for deep infiltrative endometriosis has changed; the nature of interventions tends to be radical, while developing algorithms that ensure the safety of patients. To date, there is not only a complete classification of the disease, but, as a result, there is no single strategy for managing patients with deep infiltrative endometriosis. The international experience of gynecologists was compiled with the aim of comparing the knowledge accumulated at the present stage about the problem of deep infiltrative endometriosis of the rectovaginal septum with the involvement of the rectum.

This publication is devoted to the most common problem in women of reproductive age - dysmenorrhea. Unfortunately, the underestimation of the importance of dysmenorrhea often occurs on the part of both patients and doctors. Meanwhile, dysmenorrhea causes not only a decrease in the quality of life, but also a number of serious disorders, including the risk of developing endometriosis, adenomyosis and even tumorous diseases. With such articles as prevention and prevention of diseases.

This publication examines the existing risks of obstetric complications and other reproductive disorders in women with gynecological diseases. The paper also discusses the issues of the pre-school training of women with gynecological diseases, with special emphasis on the use of dipyridamole, due to its pleiotropic action.

Inflammatory diseases occupy leading positions in the list of gynaecological pathology. Inflammatory diseases of the pelvic organs (PID) recorded in 60-65% of women of reproductive age have a very negative impact on the female reproductive function, and cause chronic pelvic pain syndrome in 24% cases, infertility in 40%, miscarriage in 45%, and ectopic pregnancy in 3% of cases [1-3, 5, 7-9, 12, 13, 15-17, 20, 23]. Among inflammatory diseases in gynecology, endometritis and cervicitis account for about 70-80% of cases; however, the asymptomatic nature of the majority of endometritis and cervicitis cases (chronicity of the inflammatory process) and the fact of their being diagnosed only at routine gynecological exams, lead us to suggest that their incidence is much higher [4, 6, 10, 11, 14, 18, 19, 21, 22].

The article describes the present views on the etiology, pathogenesis and morphogenesis of uterine myoma. The data on the role of steroid hormones and their receptors, growth factors, and processes of proliferation and apoptosis, and also compares the types of growth of uterine myoma according to the histological types of tumor development. Pressing questions organ preservation treatment of uterine myoma in women of reproductive age.

Prospective examination of 21 pregnant women with chronic arterial hypertension, 81 pregnant women with preeclamsia of various degree of severity and 25 healthy pregnant women was conducted. Comparative assessment of neurospecific proteins NSE and GFAP in blood serum and also immunomorphologic investigation of placenta tissue in women with hypertension and preeclampsia was demonstrated. Compared to blood serum and placenta tissue taken from women with preeclamsia, in women with arterial hypertension neurospecific proteins with high immunogenic activity that may lead to development of severe immunopathologic process were not discovered. Pregnancy prolongation with adequate hypotensive therapy and good blood pressure control is possible. Development of preeclampsia is associated with sudden increase in neurospecific protein levels, severe immune endothelial damage of macro-and microcirculation vessels; To stop the progression of this process is possible only with delivery, that is indicated in case of eclampsia, severe preeclampsia and in its moderate forms ineffective treatment.

Uterine cervical cancer is on the 3rd place of cancerous diseases morbidity in Russia. Uterine cervical cancer is caused by persistent papillomavirus infection (PVI), therefore the main factor of uterine cervical cancer prevention is screening and vaccination against human papillomavirus (HPV). Uterine cervical cells infection with HPV is necessary, but not sufficient for their malignancy. Its important to provide adequate therapeutic measures to eliminate HIV from the organism, if infection already occurred. One of the effective methods of PVI complex conservative therapy is stimulation of cell immunity by use of natural purine analogue inosine pranobex (IP) as an immunostimulator. IP antivirus effect is associated with suppression of replication of DNA and RNA viruses by bounding to cell ribosome. Immunomodulating capacity of IP is characterized by stimulation of nonspecific immunity, enhanced interleukin production, increased antibodies synthesis, stimulation of chemotaxic and phagocytous activity of monocytes and macrophagues and polymorphonuclear cells. In present article data on open and double blind placebo-controlled studies of IP are summarized. These studies confirm IP efficacy in HPV-infection therapy.

Chronic endometritis (CE) a common disease with no unified concept of pathogenesis, characterized by undulating and ever-progressive pathological process. Important pathogenic factors contributing to the development of CE, is immune deficiency and violation of endometrium angioarchitectonics. Currently has been widely discussed question of the proand antioxidant systems imbalance role in the pathogenesis of HE. From these positions, it is obvious that the stimulation of natural antioxidant systems, introduction of exogenous antioxidants one of the essential moments in the treatment of CE. Actovegin is a one of the modern drugs which is best meets the requirements of CE pathogenic-based therapy and has an impact on the above links of pathogenesis. Actovegin contains components with high biological activity: amino acids, oligopeptides, nucleosides, oligosaccharides and glycolipides, enzymes, electrolytes, and a number of important macroand micronutrients. Exacerbation of already existing chronic inflammation often occurs after an abortion and therapeutic surgical procedures. Therefore, an important measure to prevent the exacerbation of chronic endometritis, an essential part of the treatment of post-abortion or postpartum CE, treatment and diagnostic curettage is the rehabilitation of structural and functional state of the endometrium with the use of Actovegin.