In this research blood serum was tested for specific antibodies so as to investigate the immune system tension in distant periods after the immunization with the tick-borne encephalitis vaccine EnceVir®. It was shown that twelve months after the completion of the initial course of vaccination all the vaccinated adults had specific IgG, with titer rate varying from 1:800 to 1:3200. The retrospective analysis of the vaccines side effects revealed several batches with an elevated number of temperature reactions. Nevertheless, over 80% of the used vaccine batches did not contradict with the EnceVir® instruction manual in terms of the number of side effects.

The article presents the history of the creation and development of Tomsk Bacteriological Institute named after Ivan Churin and Zinaida Churina from the time of its foundation till the present day. The main stages in the development of the scientific trends and production activities of the Institute as well as its role in combating epidemics are shown. The article reveals the contribution of the leading scientists to the development of microbiology and immunobiological drugs manufacture.

Inactivated vaccine ОspaVir which was created in the NPO VIRION based upon high immunogenic vaccine virus strain of L-IVP is proved to be safe and having high immunologic activity. The vaccine does not decrease total immunity.

Technology of variola inactivated vaccine OspaVir in one dose in ampulla is developed aimed at primary vaccination of small children, teenagers and adults during 2-stage vaccination against variola. The strain of vaccine virus L-IVP was used in the work. Clinical tests results demonstrated low rectogeneity and high immunologic activity of the preparation while using it in the 1-st stage of vaccination.