The calcium-carbonate-induced mineralization of multilayer shells of emulsion capsules, formed using layer-by-layer assembly of polyelectrolytes, has been investigated. Optimal conditions for forming microcapsules with a core from shea butter and an organic–inorganic shell from synthetic polyelectrolytes and calcium carbonate are found. The shell morphology and stability of capsules in an aqueous suspension upon heating are investigated, and their cytotoxicity for human fibroblast cells is estimated. It is shown that mineralization of emulsion polyelectrolyte capsules by calcium carbonate in the form of vaterite strengthens the capsule walls and increases their biocompatibility.

Development microcarriers of biologically active substances for creation of new drugs should also give the required physicochemical properties to the dosage form. The effect of liquid plant extract of chamomile flowers, calendula flowers and yarrow herbs on microparticles vaterite and microparticles microcrystalline cellulose was studied. When grinding microcrystalline cellulose, (first mechanically and then by ultrasound), microparticles with fractional composition were obtained (from 1 to 100 nm - 0%, from 100 to 1000 nm - 88% and from 1000 to 10000nm - 12%). Comparative analysis the technological characteristics these microparticles by SeDeM method shown that microcrystalline cellulose particles are promising for development of solid dosage form based thereon with liquid plant extract by direct compression.