The interrelation of persistence of Helicobacter pylori in stomach with innate and adaptive immunity of human has been discussed. The analysis of the mechanisms of immunological recognition of the antigens of this microorganism and response to them has been performed. It has been considered, that the development and course of gastritis and ulcer in human with Helicobacter pylori stipulate for inadequate reactions of immune system and common reactivity by the individual organism in presence of Helicobacter pylori in mucus of stomach.

In discussional article argue unfounded of infectious hypothesis of the pathogenesis of ulceral disease of gastric and duodenum.

The purpose of the research was the study of cellular immune status and serum cytokines at pregnant patients with pyelonephritis. We have studied 106 pregnant with purulent pyelonephritis. 50 patients with serous pyelonephritis s and 30 healthy pregnant were the group of control. Clinical, microbiological and immunological methods of research have been used. Distinctions in parameters of cellular immune status and serum level of interleukin-1-betta, interleukin-8, interleukin-4, interleukin-10 and interferon-gamma at pregnant patients with serous and purulent pyelonephritis were determined. Deep depression of cellular immunity, the increase of serum concentration of interleukin-1b, interleukin-8, interleukin-4, interleukin-10 and lower contents of interferon-gamma were registered at pregnant patients with purulent pyelonephritis. Most radical immune changes at patients with apostems and renal abscess were registered. Criteria of early diagnostics of a bacterial shock by pyelonephritis in pregnancy are offered.