Purpose To investigate the effects of nasopharyngeal tube on the postoperative respiratory complication of uvulopalato pharyngoplasty(UPPP) of patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods The assessing parameter included decompensation, the lowest SaO2, pharynx ache, and pharynx edema in 43 patients (treated group) with nasopharyngeal tube after UPPP and 22 patients (control group)without nasopharyngeal tube after UPPP. Two groups were compared in 24 hours and in 48 hours. Nasopharyngeal tube (diameter 8 mm) was placed from the nasal cavity to the lower of the tongue base. Results In 24 hours after UPPP, there was significant difference (P<0. 01 ) in decompensation between the treated group (0) and the control group (0. 23±0. 43) , there was significant difference in the lowest oxygen saturation (P<0. 01) between the treated group (0. 37±0. 54) and the control group (1. 23±0. 72 ); there was no significant diffei in pharynxache(P>0. 01) between the treat group (2. 30±0.56) and the control group (2. 27±0. 55); there was no significant difference in pharynx edema(P>0. 01) between the treated group ( 1. 10±0. 56) and the control group ( 1. 23±0. 69). In 48 hours after UPPP. there was no signil difference in decompensation (P>0. 01 ) between the treated group (0) and the control group (0); there was significant difference in the lowest oxygen saturation (P<C. 01 ) between the treated group (0. 51±0. 59) and the control group ( 1. 09±0. 81); there was no significant difference in pharynx ache (P>0.01 ) between the treat group (1. 60±0.62) and the control group ( 1. 62±0. 70) ; there was no significant difference in pharynx edema (P>0.01 ) between the treated group (1. 10±0. 56) and the control group (0. 98±0. 63). Conclusions Nasopharyngeal tube may significantly decrease the incidence of decompensation and the lowest oxygen saturation after uvulopalatopharyngoplasty(UPPP) on severe obstructive sleep apnea hypopnea syndrome(OSAHS) the duration of intubation of nasopharyn- geal tube is 24 hours.

Objective:To study the characteristics of regional recurrence and cervical metastasis in squamous cell carcinomas of the larynx after total laryngectomy. Methods: A retrospective tumor registry analysis was made of 108 patients with squamous cell carcinomas of the larynx after total laryngectomy. Results: In 108 patients with squamous cell carcinomas of the larynx, cervical metastasis occurred in 48 patients and regional recurrence occurred in 8 patients,patients with regional recurrence had a poor prognosis. Of 48 patients with cervical metastasis, 18 occurred before total laryngectomy,30 occurred after total laryngectomy. cervical lymph node metastases were related to tumor location and advanced initial tumor, lymph node metastases were significantly higher in supraglottic carcinomas than glottic carcinomas and in tumors staged T3 or higher than staged T2 (P 0.01). Conclusion:Cervical metastasis is a frequent appearance in squamous cell carcinomas of the larynx,The surgeon should be aware of the relatively high incidence of cervical metastases in patients with laryngeal squamous cell cancer to establish optimal treatment approaches. Intensive follow-up should be performed for patients with advanced initial tumor and supraglottic carcinomas after total laryngectomy.

Objective: To determine whether Dexamethasone may reduce the incidence of syndrome of UPPP. Methods: 30 cases of UPPP injected Dexamethasone were selected as the treat group and 30 cases of UPPP not injected Dexamethasone were selected as the control group. The incidence of syndrome of UPPP were detected. Results: The incidence of syndrome of UPPP in the treat group was significantly lower than in the control group. Conclusion: Dexamethasone may reduce the incidence of syndrome of UPPP.

ObjectiveTo study the microvessel density(MVD)and expression of p53 and thsese relation with tumor growth and lymph node metastasis of human laryngeal squamous cell cancer(LSCC). MethodsImmunohistochemical analyses(Envision method) using antibodies against CD34 and p53 were carried out on archival specimens of 54 human laryngeal squamous cell cancers and 10 cases of polyp of vocal cord. Results1. MVD and expression of p53 were higher in LSCC than in polyp of vocal cord(P0.01). 2. Expression of p53 in LSCC was related to TNM category and cervical node metastasis(P0.05). 3. MVD was higher in LSCC with positive lymph node than that with negative lymph node(P0.05). 4. The relationship between MVD and p53 expression in LSCC had no statistic significance (P0.05). ConclusionMVD and p53 expression were related to the growth of LSCC, they are helpful in predicting the prognosis of LSCC patients.

Purpose To study the relationship between the microvessel density (MVD) and expression of laminin (LN) and cervical lymph node metostasis of laryngeal squamous cell cancer (LSCC) . Methods Immunohistochemical analyses (Envision method) using antibodies against CD34 and LN was carried out on archival specimens of 54 human laryngeal squamous cell cancer. Results (1) MVD was higher in LSCC with positive lymph node than that with negative lymph node (P0.05). (2) Expression of LN in LSCC was related to cervical node metostasis (P0.05).(3) The relationship between MVD and LN expression in LSCC had no statistic significance (P 0.05). Conclusions MVD and LN expression were helpful in predicting LSCC patients at risk for cervical lymph node metastasis.

目的:研究喉鳞癌中P53表达与意义.方法:应用免疫组织化学方法(Envision),检测63例喉鳞癌、7例喉乳头状瘤、10例声带息肉组织中P53基因蛋白的表达.结果:(1)P53在上述三种组织中表达率分别为51%、28%、0%,差异有统计学意义(P＜0.01);(2)P53表达与喉鳞癌病理组织分级及临床分期(TNM)相关,P53阳性表达者,其肿瘤组织病理分级差(P＜0.05),Ⅰ、Ⅱ期肿瘤阳性表达率低于Ⅲ、Ⅳ期(P＜0.05);(3)P53阳性表达与颈淋巴结转移无关(P＞0.05).结论:P53在喉上皮中的表达与其恶性程度相关,P53表达者其预后可能不良.

鼻咽纤维血管瘤常发生于青春期男性,发病原因不明.因其源于颅底,肿瘤生长扩张能力强,而且血供丰富易致凶猛的大出血,故临床上虽属良性,但发展甚恶.其治疗主要靠手术彻底切除,但由于瘤体血供丰富,术中出血量大,影响手术视野,给根治造成困难.我科采用术前动脉栓塞术,治疗1例,取得满意疗效,现报告如下.