142 patients were examined: I group (n=58) patients with multiple sclerosis (MS ) and tremor; II group (n=66) MS without tremor; III group (n=10 ) patients with Parkinson's disease (PD); IV group (n=8) patients with essential tremor (ET); V group (n=10) healthy young volunteers. Clinico-neurophysiological examination included digital spiralography, EMG-tremorography, somatosensory evoked potentials, transcranial magnetic stimulation with tremor resetting, shortand long-latency reflexes. We revealed that tremor in MS develops during more active disease course with the dominance of brainstem and cerebella symptoms. We allocated 5 variants of tremor in MS, which differ from each other in their clinical and neurophysiological characteristics. Compared with PD and ET patients, tremor in MS patients is characterized by more variable clinical characteristics, high amplitude and impact on disability. Extrapolation of some aspects of the tremor generation in PD and ET patients helps to clarify the pathophysiology of shaking hyperkinesis in MS patients.
The authors carried out clinical-instrumental study of 27 patients with chronic inflammatory demyelinating polyradiculoneuropathy. The features of clinical, MRI and VEP of 7 patients who had chronic inflammatory demyelinating polyradiculoneuropathy combined with lesion of CNS myelin are presented.