目的:探讨急性脑梗死患者血浆t-PA、PAI-1水平的变化及临床意义.方法:测定神经内科住院的40例急性脑梗死患者24小时、14天血浆t-PA、PAI-1及38例健康体检者24小时的血浆t-PA、PAI-1水平.结果:急性脑梗死患者t-PA、PAI-1水平与正常对照组比较明显升高(P＜0.01),治疗14天后较24小时均明显下降(P＜0.01).结论:检测t-PA、PAI-1在急性脑梗死的诊断及治疗中起着十分重要的作用.

Objective:To discuss the clinical characteristic of meningioma and the cytological changes of CSF(cerebrospinal fluid) and imageological changes of meningioma patients.Results:To make a retrospective analysis to a series of clinical materials from 21 cases of meningioma patients registered from January 2002 to January 2008.Result:Headache and vomiting make up a dominant portion of the primary symptoms of this disease which are sometimes accompanied by damages to cerebral and spinal nerve.The CSF pressure result from these patients increases differently.Cell number and protein content of CSF increase while the glucose and chlorides content decrease.Cancer cells can be found by cytological examination.Conclusion:Imageological and CSF cytological examination are two significant proofs for the diagnosis of meningioma.They need to be performed repeatedly.

Objective To study the principle,methodolgy,accuracy and clinical diagnostic values of DSA in detecting intracranial aneurysms.Methods Forty intracranial aneurysms were confirmed by 3D-CTA,3.0T MRA,DSA,and operation,and the diagnostic accuracy of DSA was assessed.Results The diagnostic accuracy of DSA was 92%.The advantages compared to 3D-CTA,3.0T MRA could not be replaced.Conclusion DSA has high accuracy on detecting intracranial aneurysms.It is golden standard.

应激性上消化道出血是脑出血严重的并发症之一,观察护理治疗是否合理及时,直接关系到病人的生存及愈后 .我院从2005-01～2007-12共收住院脑出血并发应激性上消化道出血56例,经进行积极的治疗及护理,取得满意效果,现将护理体会介绍如下.

Objective To study the relations between acute neurolonic impairment and prognosis in Cerebral infarction by OCSP。Methods 341 consecutive patients with first acute cerebral infarction were prospectively identified and classified as OCSP.The patients were followed up at 1,3 and 6 mouths after stroke.Outcomes measures were included death,disability and recurrence.ResultsMortality of TACI was the highest and TACI had the highest rate of case fatality and disablity.Conclusion The classification of OCSP can be helpful in assessing neurolonic impairment and prognosis of cerebral infarction patients.

目的评价路优泰对脑卒中后抑郁症的疗效和不良反应。方法对68例患者分别以路优泰和赛乐特(帕罗西汀)治疗,用Hamilton抑郁量表(HAMD)评分、抑郁自评量表(SDS)及不良反应症状量表(TESS)评定疗效和不良。结果两组疗效、减分率比较无显著差异(P>0.05),但路优泰不良反应少而轻,服药简便,依从性好。结论路优泰是一种安全、有效的新一代抗抑郁剂。

Objective To investigate the effect and cerebralfluid change of migraine by treatment with hyperbaric oxygen.Methods Hyperbaric oxygen combing drugs to treat for migraine,and observe their effection.Results The total of efficiency was 84.4%.Conclusion It is an effective method that hyperbaric oxygen combing drugs to treat for migraine.

Objective To study the change of P - seclectin and the effect of defibrin with acute cerebral infraction. Methods 96 cases were divided into defibrin group (56 cases) and Aspirin group (40 cases), 30 normal people as control group .The change of P - selectin was detected respectively, and the effects of defibrin to glucose, blood lipids, fibrinogen were observed. Results The level of P - seclectin in defibrin group and Aspirin group were higher than that of control group (P < 0.01); the level of P - selectin in defibrin group and Aspirin group were decreased ( P < 0.01) . It was no signficant defferences between defibrin group and Aspirin group ( P > 0.05); the level of fibrinogen was decreased after therapeutic (P<0.01) .Conclusion P- selectin takes part in the injury pathology process in acute cerebral.Defibrin may block the express of P - selectin and decrease fibrinogen signficintly.

目的:观察脑脊液持续引流治疗蛛网膜下腔出血(SAH)的疗效.方法:对住院的SAH患者31例应用脑脊液持续引流为治疗组,25例常规治疗为对照组.结果:两组病人头痛缓解时间、脑积水发生例数、脑血管痉挛发生例数、消化道出血例数、肾功能损害例数,经统计学处理有显著差异(P＜0.05).治疗组死亡1例,对照组死亡5例,有显著差异(P＜0.05).结论:脑脊液持续引流治疗SAH可减少并发症,改善其预后.