BackgroundAquagenic wrinkling of the palms (AWP) is an excessive and early palmar wrinkling occurring after brief immersion to water (BIW), and has been reported as a frequent finding among Cystic Fibrosis (CF) patients. ObjectivesTo investigate any associations of CF patients presenting AWP with other disease characteristics and explore the pathomechanism of AWP phenomenon. MethodsWe evaluated AWP in CF patients and assessed the AWP parameters of palmar wrinkling, oedema, papules, pruritus and pain at 3, 7 and 11 min after a BIW test with other disease characteristics. Statistical analyses explored the associations of AWP with genotype, lung function, pancreatic insufficiency, hyperhidrosis, personal and family history of atopy and sweat chloride levels. ResultsOne hundred CF patients (mean age 10.4 years) were included in the analysis. The genotypic distribution was & UDelta;F508/& UDelta;F508: 47%, & UDelta;F508/other: 41% and other/other: 12%. Statistically significant associations of Kaplan-Meier curves of the AWP parameters with various disease characteristics and personal/family history were detected. Wrinkling was associated with history of atopy, hyperhidrosis and levels of sweat chloride test. The time to presentation of oedema and the appearance of papules were associated with history of hyperhidrosis and age at diagnosis. Finally, time to appearance of pruritus was related to history of atopy and of hyperhidrosis. Regarding TEWL regression analysis showed significant associations with age at diagnosis (p = 0.024), sweat chloride test levels (p = 0.005), history of hyperhidrosis (p = 0.033), history of atopy (p = 0.002) and hepatic-pancreatic involvement (p = 0.027). ConclusionsThe existence of a statistically significant association between AWP and the history of hyperhidrosis, atopy, sweat chloride levels and hepatic-pancreatic function in CF patients was detected. A strong association between AWP and CF was detected. AWP after BIW could be elicited easily and possibly can be used as an initial screening tool to diagnose an individual with symptoms and signs that raise the likelihood of CF.

Linked article: A. Alexopoulos et al. J Eur Acad Dermatol Venereol 2021; 35:1717–1724. https://doi.org/10.1111/jdv.17312.

BACKGROUND:The first dermatology-specific proxy health-related quality of life (HRQoL) instrument for children 0-4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross-cultural inequivalence focus groups work and pilot tests were organized simultaneously in all national centres of the project. The InToDermQoL showed good comprehensibility, clarity and acceptance. OBJECTIVE:To validate the InToDermQoL questionnaire during international field tests. METHODS:Internal consistency, test-retest reliability, convergent and discriminant validity of the InToDermQoL questionnaire were checked during international field tests. RESULTS:Parents of 473 children with skin diseases filled in the national language versions of the InToDermQoL questionnaire. All three age-specific versions of the InToDermQoL questionnaire with 10, 12 and 15 items, respectively, showed high internal consistency (Cronbach's α 0.90-0.93), good test-retest reliability (correlation coefficients > 0.9), significant correlations with the most widely used atopic dermatitis-specific proxy instrument, the Infants Dermatitis Quality of Life Index (correlation coefficients 0.68-0.79). The InToDermQoL versions for children <3 years old well correlated with the atopic dermatis severity measure Scoring of Atopic Dermatitis (correlation coefficients 0.66 and 0.86 for 10 and 12 items versions, respectively). The InToDermQoL questionnaire discriminated well among different diagnoses and disease severity levels. CONCLUSION:Our field tests confirmed internal consistency, test-retest reliability, convergent and discriminant validity of the InToDermQoL questionnaire. Development and validation of the InToDermQoL questionnaire make it possible to assess dermatology-specific aspects of HRQoL in youngest children with skin diseases. There are many reasons to assess HRQoL in dermatologic clinical practice, and we hope that our new instrument will be used internationally in paediatric dermatology for research and practical needs.

Journal of the European Academy of Dermatology and VenereologyVolume 33, Issue 5 p. e199-e200 Letter to the Editor Atenolol treatment for severe infantile hemangiomas: comparison with a propranolol group of our centre M. Dakoutrou, Corresponding Author M. Dakoutrou mariadak@yahoo.com First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceCorrespondence: M. Dakoutrou. E-mail: mariadak@yahoo.comSearch for more papers by this authorA. Alexopoulos, A. Alexopoulos First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorM. Miligkos, M. Miligkos First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorE. Georgiadou, E. Georgiadou First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorC. Kanaka-Gantenbein, C. Kanaka-Gantenbein First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this author M. Dakoutrou, Corresponding Author M. Dakoutrou mariadak@yahoo.com First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceCorrespondence: M. Dakoutrou. E-mail: mariadak@yahoo.comSearch for more papers by this authorA. Alexopoulos, A. Alexopoulos First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorM. Miligkos, M. Miligkos First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorE. Georgiadou, E. Georgiadou First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorC. Kanaka-Gantenbein, C. Kanaka-Gantenbein First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, University of Athens, "Aghia Sofia" Children's Hospital, Athens, GreeceSearch for more papers by this author First published: 01 February 2019 https://doi.org/10.1111/jdv.15464Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume33, Issue5May 2019Pages e199-e200 RelatedInformation

BACKGROUND:Until now, there was no validated dermatology-specific health-related quality of life (HRQoL) instrument to be used in youngest patients.OBJECTIVE:To create dermatology-specific proxy instrument for HRQoL assessment in children from birth to 4 years.METHODS:International focus groups, item selection and pilot tests were utilized. In order to avoid the problem of cross-cultural inequivalence, focus group work and pilot tests were planned simultaneously in all national centres of the project. Comprehensibility, clarity, acceptance and internal consistency of new instrument were checked.RESULTS:The title 'Infants and Toddlers Dermatology Quality of Life' was chosen for our new instrument with the proposed acronym 'InToDermQoL'. Focus group work was completed in seven national centres (Croatia, Germany, Greece, Malta, Poland, Romania and Ukraine). A total of 170 families of children with different skin diseases were interviewed, and a pilot version of the instrument was created. Centres from France, Denmark and Spain have joined the project at this stage. Parents of 125 children with skin diseases filled in the pilot versions of the instrument. Good comprehensibility, clarity, acceptance and internal consistency of the InToDermQoL were confirmed. The pilot test results showed that the InToDermQoL questionnaire well differentiates severity-dependent differences. It was also checked and confirmed during the pilot test that no significant information was missed in the questionnaire. Three age-specific versions of the InToDermQoL questionnaire with 10, 12 and 15 items, respectively, were approved for field tests.CONCLUSION:The pilot test results showed that the InToDermQoL questionnaire has good comprehensibility, clarity, acceptance and internal consistency and well differentiates severity-dependent differences. Further validation of the InToDermQoL during international field test will be performed.

Journal of the European Academy of Dermatology and VenereologyVolume 32, Issue 3 p. e117-e119 Letter to the Editor Atenolol treatment for severe Infantile Hemangiomas: a single-centre prospective study A. Alexopoulos, Corresponding Author A. Alexopoulos atosmedicals@yahoo.co.uk First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceCorrespondence: A. Alexopoulos. E-mail: atosmedicals@yahoo.co.ukSearch for more papers by this authorI. Thanopoulou, I. Thanopoulou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorM. Dakoutrou, M. Dakoutrou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorE. Georgiadou, E. Georgiadou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorG.P. Chrousos, G.P. Chrousos First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this author A. Alexopoulos, Corresponding Author A. Alexopoulos atosmedicals@yahoo.co.uk First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceCorrespondence: A. Alexopoulos. E-mail: atosmedicals@yahoo.co.ukSearch for more papers by this authorI. Thanopoulou, I. Thanopoulou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorM. Dakoutrou, M. Dakoutrou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorE. Georgiadou, E. Georgiadou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorG.P. Chrousos, G.P. Chrousos First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, "Aghia Sofia" Children's Hospital, University of Athens, Athens, GreeceSearch for more papers by this author First published: 18 September 2017 https://doi.org/10.1111/jdv.14590Citations: 6Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume32, Issue3March 2018Pages e117-e119 RelatedInformation

Journal of the European Academy of Dermatology and VenereologyVolume 30, Issue 10 p. e46-e47 Letter to the Editor The child with vasculitic rash: a 10-year retrospective study A. Alexopoulos, Corresponding Author A. Alexopoulos atosmedicals@yahoo.co.uk First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceCorrespondence: A. Alexopoulos. E-mail: atosmedicals@yahoo.co.ukSearch for more papers by this authorA. Gkourogianni, A. Gkourogianni First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorK. Stefanaki, K. Stefanaki First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorK. Theodoridou, K. Theodoridou First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this author A. Alexopoulos, Corresponding Author A. Alexopoulos atosmedicals@yahoo.co.uk First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceCorrespondence: A. Alexopoulos. E-mail: atosmedicals@yahoo.co.ukSearch for more papers by this authorA. Gkourogianni, A. Gkourogianni First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorK. Stefanaki, K. Stefanaki First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorK. Theodoridou, K. Theodoridou First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this authorT. Kakourou, T. Kakourou First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, GreeceSearch for more papers by this author First published: 15 September 2015 https://doi.org/10.1111/jdv.13291Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume30, Issue10October 2016Pages e46-e47 RelatedInformation

CHILD syndrome is a rare X‐linked dominant condition that presents with congenital hemidysplasia, Ichthyosiform erythroderma, and limb defects in affected patients. We report the case of a 10‐year‐old girl treated with topical simvastatin and cholesterol ointment, after which her skin lesions significantly improved within the first 30 days of treatment.

Background The studies of series of children with Kawasaki disease (KD) in Greek children are limited. Objectives To evaluate the epidemiology, clinical manifestations, laboratory findings, course and outcome of complete KD in Greek children. Methods Patients with complete KD who were discharged from our hospital and followed up routinely between 2004 and 2011 were included in the study. The relevant data were collected using a standardized form. Results There were 49 children (27 boys, 22 girls), mean age: 2.14 years. A seasonal peak of the disease during spring and summer months was detected. Changes of the extremities and cervical adenopathy were the least commonly met criteria for the complete KD diagnosis. The mean time of starting treatment was 6.5 days from the disease onset. The majority of patients, 42/49, responded well to a single infusion of intravenous immunoglobulin (IVIG), while 7/49 patients who had persistent fever despite initial therapy with IVIG needed additional treatment with either a second dose of IVIG(5), intravenous pulse of methyl prednisolone(1) or infliximab(1). Coronary artery abnormalities were detected echocardiographically in 17/49 patients. Most of them (15/17) developed transient dilatations which resolved by the 8th week of disease onset while only 2 patients, despite early onset of treatment, developed coronary artery aneurysms which required coronary artery bypass grafts at a later stage. Conclusions Major epidemiologic features of KD detected among Greek children are similar to those reported in other populations. This study also demonstrates that significant cardiac complications may still occur following the disease even if it is diagnosed and treated early.