Cutaneous B cell lymphoma is not commonly seen and occurs in only 8.2% of non-Hodgkins lymphoma. Although Ga-67 uptake by cutaneous T cell lymphoma has been reported, the literature on Ga imaging in cutaneous, B cell lymphoma is limited. The authors report the gallium scan and clinical findings on 2 cases of cutaneous B cell lymphoma.

18F-2-Deoxy-2-fluoro-D-glucose (18FDG) is rapidly extracted by the mouse heart, and the radioactivity in heart (3-4% per organ) remains relatively constant for 2 hr post injection. The brain uptake (2-3% per organ) remained relatively constant throughout the time course of the study. Liver, lungs, kidneys, small intestine, and blood all showed a rapid clearance of radioactivity after injection of 18FDG. At 120 min the heart-to-lung ratio was 12 and heart-to-liver ratio was 32. Urinary excretion of activity was approximately 16% of the injected dose at 60 min. The uptake of radioactivity by dog heart following the intravenous administration of 18FDG was 2.8-4.1% at 60 min and 2.4% at 135 min; it was regionally distributed, the areas of highest activity being the left ventricle and the interventricular septum. The brain activity was 2.1-3.5% at 120 min, with a ratio of gray matter-to-white matter of 2-3:1. Urinary excretion in dogs was 16% and 50% of the injected dose at 60 and 135 min. The chemical form of the activity in the urine, although unidentified, was not 18F-. Cross-sectional images of the myocardium of the dog after intravenous injection of 18FDG were obtained using emission tomography.

Xenon-133 and xenon-127 were compared by performing ventilation studies with both radionuclides in 19 patients with a variety of lung diseases. Assessment of the counting rate over the chest, relative to the radioactivity in the lungs, permitted the evaluation of each isotope in terms of usable photons detected by a scintillation camera with a large field of view and appropriate collimation. A greater photon yield was obtained with Xe-127. Markedly improved resolution was shown by measurement of a line phantom, but was not apparent on subjective appraisal of scintiphotos except in the washout phase. Xenon-127 appears to be preferable to Xe-133 because of the higher counting rates, lower patient radiation dose, and longer shelf life. In addition, a prior perfusion study using a Tc-99m radiopharmaceutical does not affect the quality of a Xe-127 ventilation study. The use of Xe-127 therefore permits the selection for ventilation studies of only those patients with suspected pulmonary embolism, and eliminates unnecessary radiation exposure. A further improvement in image quality obtained with Xe-127 should be possible with certain modifications of the scintillation camera that would permit use of the 375-keV photopeak along with the 172- and 203-keV gamma energies. Charcoal traps designed for Xe-133 willmore » require additional shielding and longer storage time when used for Xe-127. Xenon-127, however, might be used again after appropriate processing.« less

This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup 123/I-ICG (in dogs) will be compared to /sup 131/I-rose bengal and bromosulphalein labeled with iodine-125.

Carrier-free /sup 11/C-labeled dopamine hydrochloride was synthesized using carrier-free H/sup 11/CN as a precursor. Tissue distribution studies on five dogs showed a specific localization in the adrenal medu1la. Tissue distribution studies with /sup 11/C-labeled noradrenaline are in progress. (auth)

The catecholamines, dopamine, norepinephrine, and epinephrine, are synthesized and secreted by tissues such as brain, sympathetic nerve endings, and chromaffin cells. Dopamine and norepinephrine are primarily neurotransmitters while epinephrine functions mainly as a hormone. The biosynthesis of the catecholamines from tyrosine is reviewed. Abnormalities in the quantities and metabolism of these compounds are associated with many pathological conditions such as hypertension, Parkinsonism, and chromaffin tissue tumors. Rapid synthetic methods (for the preparation off)/sup 11/C-labeled catecholamines have been developed. The potential use of these labeled catecholamines as scanning agents for the adrenal glands and heart myocardium was evaluated in dogs. (CH)