No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 Feb 2001SMALL BLADDER AND MULTIPLE URETHRAL RECURRENCES AFTER INTRAVESICAL INSTILLATION OF BACILLUS CALMETTE-GUERIN FOR SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF THE BLADDER PASQUALINO MANASIA, ANTONIO ALCARAZ, ALFREDO CETINA, and JUAN ALCOVER PASQUALINO MANASIAPASQUALINO MANASIA More articles by this author , ANTONIO ALCARAZANTONIO ALCARAZ More articles by this author , ALFREDO CETINAALFREDO CETINA More articles by this author , and JUAN ALCOVERJUAN ALCOVER More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-200102000-00050AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "SMALL BLADDER AND MULTIPLE URETHRAL RECURRENCES AFTER INTRAVESICAL INSTILLATION OF BACILLUS CALMETTE-GUERIN FOR SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF THE BLADDER." The Journal of Urology, 165(2), pp. 529–530 References 1 : Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer. J Urol1986; 135: 272. Link, Google Scholar 2 : Bladder contracture following intravesical BCG immunotherapy. Urology1993; 41: 353. Google Scholar 3 : Superficial transitional cell carcinoma of the bladder associated with mucosal involvement of the prostatic urethra: results of treatment with intravesical bacillus Calmette-Guerin. J Urol1988; 139: 290. Link, Google Scholar From the Department of Urology and Renal Transplantation, Hospital Clinic, University of Barcelona, Barcelona, Spain© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 165Issue 2February 2001Page: 529-530 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsmycobacterium bovisurethracarcinoma, transitional cellbladderMetrics Author Information PASQUALINO MANASIA More articles by this author ANTONIO ALCARAZ More articles by this author ALFREDO CETINA More articles by this author JUAN ALCOVER More articles by this author Expand All Advertisement PDF downloadLoading ...

BACKGROUND. High-grade prostate intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma. However, the relationship between this lesion and prostate cancer has not yet been established. The detection of cytogenetic changes in the lesions prior to prostate adenocarcinoma would be useful in demonstrating such a pathogenic relationship.METHODS. Twenty eight high-grade PIN cases were found among 57 specimens of radical prostatectomy performed for clinically localized prostate cancer. Fluorescence in situ hybridization (FISH) analysis using centromeric probes to enumerate chromosomes 7, 8, 10, and 12 was performed to study the numerical chromosome alterations. FISH analysis was carried out over isolated nuclei obtained from high-grade PIN areas and prostate cancer foci in the same prostatectomy specimen.RESULTS. Of the 28 suitable casts it was possible to complete the study in 26 tumor and 20 PIN areas. The remaining cases were excluded because of insufficient tissue or poor preservation. Cytogenetic alterations (aneuploidy) were found in 16 of the 26 (62%) tumors studied. The most frequent chromosome alteration was trisomy 7, detected in 12 (7570) aneuploid tumors, followed by monosomy 8 present in 5 (31%) aneuploid tumors. Trisomy 7 was also the most frequent isolated chromosome alteration since it was detected in 7 (44%) tumors. Thirteen of 20 (65%) PIN cases were aneuploid when studied by FISH. Trisomy 7, trisomy 8, and monosomy 8 were the most common cytogenetic alterations in the 20 PIN areas studied, being observed in nine (45%), six (30%), and four (20%) cases, respectively. FISH analysis showed a high correlation (75% cases) in ploidy and pattern of cytogenetic alterations between high-grade PIN areas and the paired prostate cancer focus in the same specimen.CONCLUSIONS. The above results show a cytogenetic link between high-grade PIN and prostate cancer, suggesting that the former could be an early form of prostate cancer. Prostate 47:29-35,2001. (C) 2001 Wiley-Liss,Inc.

Behavior of transitional cell carcinoma of the bladder during the third decade of life remains a controversial subject. During the period 1980-1988, we treated 7 patients (4 male and 3 female), 25 years of age or less (mean age 19.3, range 14-25), with transitional cell carcinoma of the bladder. Until now, all patients are alive and without disease during 12-50 months after surgery. In 6 of the 7 patients, endoscopic resection was the choice treatment for superficial stage A/O. The seventh patient underwent a partial cystectomy for a B1 Jewet stage cell carcinoma. We conclude that transitional cell carcinoma of the bladder in patients under 25 years of age has a less aggressive biological behavior. Therefore, ultrasonographic examinations and serial urine cytology represent the elective test for follow-up. Cystoscopy would only be performed in doubtful cases.