We have shown that contrary to the literature indications, phenyl isocyanate can react in very mild conditions (20 degrees) with cytosine, thymine, uracil, and adenine if these reactions are carried out in homogeneous medium (DMSO). As for guanine, the chief reason of its non-reactivity in the same conditions is its insolubility in this solvent.
A novel, efficient, and regioselective route to the potentially active pyrimidines of biological interest bearing cage system derived from adamantane is described utilizing substitution or addition reactions under solid-liquid phase transfer conditions or by a non-catalytic procedure.
A new and efficient method for oxidising sulfides selectively to sulfoxides has been developed with atmospheric oxygen, in the presence of isobutyraldehyde and catalysed by Ni-II complexes such as bis[1,3-bis-(p-methoxyphenyl)-1,3-propanedionato]nickel, [Ni(dmp)(2)], and bis[acetylacetonato]nickel, [Ni(acac)(2)].
