Amyloidosis is a group of diseases that have a wide variety of clinical manifestations. The frequency of amyloidosis in the population is about 1%; it is believed that up to 8 million people in the world have amyloidosis. The presented clinical case demonstrates the difficulty of timely intravital diagnosis of generalized amyloidosis due to the lack of a specific disease picture and characteristic laboratory changes. Timely diagnosis of amyloidosis and knowledge of its clinical features are necessary for the correct choice of management tactics for such patients, which will help reduce the incidence of deaths from amyloid.

The article presents a clinical observation of a patient with hereditary hemolytic anemia and cholelithiasis that developed from it. The record of ultrasound of the abdominal, magnetic resonance cholangiopancreatography, and the movement of laboratory parameters are demonstrated. The patient underwent splenectomy with cholecystectomy, the information of the postoperative period are presented. The purpose of the article was to study, using the example of this clinical case, the features of the course of hereditary spherocytosis complicated by cholelithiasis in an adult patient; to assess the feasibility of the presented variant of the tactics of managing patients with this pathology. It is shown that at the present stage, despite the dynamic pace of development, pharmacology does not offer effective therapy, and splenectomy remains the only method for treating hereditary spherocytosis. Removal of the spleen eliminates intrasplenic hemolysis and therefore corrects the anemia. With the development of gallstone disease as a result of hemolysis, splenectomy is performed in combination with cholecystectomy.

Purpose of the study: To assess the effect of low-mineralized sulfate-chloride-sodium mineral water (MW) on the level of motilin and cholecystokinin in the blood in functional dyspepsia and in healthy people. Materials and methods. 180 people aged 22.3±0.21 years were examined, divided into 3 groups: patients with postprandial distress syndrome (PDS) (62 people), patients with epigastric pain syndrome (EPS) (62 people), practically healthy (56 people). The severity of gastroenterological symptoms was determined using the GSRS questionnaire. In all examined patients, the concentrations of motilin and cholecystokinin in the blood were determined initially and after a single dose of 200 ml of MW. Results. The initial concentration of motilin in the blood of patients with EPS (8584,0 [7951,0; 9807,0] pg/ml) was lower than in patients with PDS (9876,0 [9340,0; 10219,0] pg/ml, p=0,000) and healthy (9779,5 [9230,0; 10027,0] pg/ml, p=0,000). The intake of MW in healthy people did not cause changes in the concentration of motilin in the blood (p=0,352), in patients with PDS it led to a decrease in its level (p=0,000), and to an increase in EPS (p=0,000). The initial level of cholecystokinin in the blood of patients with EPS (187,7 [124,0; 230,1] pg/ml) was higher (p=0,008), and in those examined with PDS (123,3 [83,5; 143,2 ] pg/ml) is lower (p=0,000) than in healthy people (145,3 [107,1; 186,2] pg/ml). MW intake led to an increase in its concentration in all three groups: healthy (p=0,014), patients with PDS (p=0,000) and EPS (p=0,000). Conclusion. Peculiarities of the dynamics of the level of motilin and cholecystokinin in the blood of patients with PDS, EPS and healthy people when taking low-mineralized sulfate-chloride-sodium MW, which must be taken into account when developing schemes for drinking balneotherapy for functional pathology of the stomach, were revealed.

BACKGROUND: One of the primary pathophysiological mechanisms of functional dyspepsia is a disruption in the postprandial reflex relaxation of the proximal part of the stomach, which results in an impairment of its motor-evacuation function. This impairment can be verified by magnetic resonance imaging with a stress drinking test. Correction of gastric relaxation accommodation disorders in functional dyspepsia is possible with the help of drinking mineral waters. However, further studies are required to assess the effect of these waters on the motor-evacuation function of the stomach. AIM: The study was aimed at comparative evaluation of the effect of intake of therapeutic medium mineralized sulfate-sodium-calcium mineral water and ordinary drinking water on gastric evacuation function using magnetic resonance tomography. MATERIALS AND METHODS: A two-fold magnetic resonance imaging procedure was conducted on an empty stomach using a closed-type Philips Intera 1.5T device (Philips, Netherlands) in 10 patients aged 22.8±1.2 years with a diagnosis of functional dyspepsia. On day 1, 200 ml of drinking water was used, and on day 2, 200 ml of mineral water was used. The examination was conducted in abdominal mode, with the subjects lying on their back. A slice thickness of 3 mm was used in coronal, axial, and sagittal projections, with images acquired every 5 minutes for 20 minutes. The following imaging modes were employed: T1, T2-weighted images, T2 Spair, and b-FFE. The volume of gastric contents and the rate of fluid evacuation were calculated using the RadiAnt DICOM Viewer program (Medixant, Poland). RESULTS: In patients with functional dyspepsia, the volume of liquid in the stomach after ingestion of 200 ml of drinking water was 163.71 ± 28.9 mL, while after ingestion of mineral water, the volume was 101.57 ± 26.88 mL. Furthermore, the volume of evacuated liquid after ingestion of mineral water was 1.040–2.5 times greater. By minute 15, the volume of liquid in the stomach was 8.0 ± 6.16 mL after mineral water intake and 58.85 ± 40.06 mL after drinking water. The mean gastric evacuation rate following ingestion of ordinary drinking water was 12.9 ± 5.29 mL/min, while that following ingestion of mineral water was 24.1 ± 4.53 mL/min (1.07–3.76 times greater). The increase in gastric evacuation rate observed in the examined subjects when using mineral water ranged from 7.58% to 276.21%. CONCLUSIONS: Magnetic resonance imaging of the stomach allows for the verification of the effect of mineral water on its motor-evacuation function, thus enabling the estimation of the rate of gastric emptying. A single intake of the studied mineral water has a prokinetic effect, which can be used to correct motor disorders in patients with functional dyspepsia.

The article presents a literature review of modern Russian and foreign publications devoted to the study of gastric accommodation. It has been shown that accommodation of the proximal stomach plays an important role in its adaptation to food intake. This process is carried out in two stages with the participation of parasympathetic and paracrine regulation; the effects of nutrients when they enter the duodenum also play an important role. Methods for assessing gastric accommodation include gastric barostat, gastric scintigraphy with food load, drinking tests, single-photon emission computed tomography, magnetic resonance imaging and ultrasound examination of the stomach, intragastric manometry. Violation of gastric accommodation leads to an excessive increase in intragastric pressure and the occurrence of symptoms most often found in functional dyspepsia, gastroesophageal reflux disease and diabetic gastropathy. Approaches to the treatment of gastric accommodation disorders are at the development stage, the possibilities of diet therapy, pharmacological and non-drug correction are being discussed.

Aim: to study opportunity of research the evacuation function of the stomach in young people by magnetic resonance imaging with a stress drinking test. Materials and methods: the study group included 20 young people (10 men and 10 women aged 23 ± 1,12 years). At the time of the study, each test person excluded organic and functional pathologies of the gastroduodenal zone. A method of magnetic resonance imaging of the stomach with a stress drinking test (still drinking water at room temperature with a volume of 1000.0 ml) was used. The examination lasted 30 minutes, scanning was carried out every 5 minutes, a total of 7 scans. Based on the obtained three-dimensional images of the DICOM format using the HorosMobile™ application (DICOM medical image viewer), the volumes of fluid in the stomach in dynamics were calculated for each test person in the study group according to the time intervals of the scans performed by the magnetic resonance imaging machine. Systematization and data processing were carried out a Microsoft Excel. A single graph was built for the study group in the Pages graphical editor (iWork productivity suite) based on the obtained data, reflecting the reference volumes of gastric contents relative to the time scale with possible deviations from the average. Results: regardless of the type of physique and shape of the stomach in the studied subjects, the evacuation of a larger volume of fluid (81,53-82,54%) occurred by the 15th minute of the study. Complete evacuation of gastric contents occurs between 25 and 30 minutes of the study. Conclusions: the results obtained by MRI studies of the stomach with a stress drinking test give an idea of the options for normal physiological evacuation of gastric contents in young people, in the absence of organic and functional pathology of the gastroduodenal zone.

The aim of the study was to reveal associations between the number of functioning microvessels and formation of adrenergic control (nerve endings containing catecholamine) of the dental pulp in children and adolescents of Udmurtia during the period of permanent teeth eruption. Material and methods. The study included neurovascular bundle of the pulp of teeth extracted for medical reasons at the age of 5 to 14 years. At the light-optical level, the number of functioning capillaries was counted; an electron microscopic technique was used to qualitative assess the microvascular bed. Identification of catecholamines and counting the number of adrenergic nerve endings were performed histochemically using glyoxylic acid. Results. The process of permanent teeth eruption is accompanied by an intensively increased number of functioning capillaries and an increased density of adrenergic nerve endings. The number of functioning microvessels increases significantly (by 3.36 times) during childhood (from 5 to 9 years); the number of capillaries stabilizes in adolescence. The increased number of nerve endings by the end of the childhood period (9 years) is 45.2 ± 12.4 % compared with the age of 5 years. Notably, adrenergic nerve endings modify qualitatively: a pronounced variety of mediatorcontaining forms is replaced by their isomorphic phenotype. With age, predominant distribution of nerve endings along the vessels of the microvasculature tends to increase. Conclusion. Active formation of the microvascular bed during the eruption of permanent teeth is accompanied by an age-dependent increase in the density of localization and qualitative restructuring of adrenergic nerve endings, which provides full catecholaminergic control from the sympathetic nervous system.

Background. Functional diseases of the gastrointestinal tract are an actual problem of gastroenterology, since the symptoms of dyspepsia are one of the most common reasons for seeking medical help. In the occurrence and development of these disorders, chronic stress and depression can often act as a causative factor. The purpose of this study is to determine the effect of depression and stress on the functional state of the gastrointestinal tract. Materials and methods. A cross-sectional study was conducted in 48 people with and without functional dyspepsia. A comparative assessment of the level of depression and stress in the studied groups of people, the impact of the above psychological conditions on the visceral hypersensitivity of the stomach was carried out. Results. Statistically significant differences in the indicators of depression and stress in persons with functional disorders of the stomach were revealed in comparison with the group of subjects without such symptoms. Statistically significant correlations were also found between the temperature of the water used in the drinking test and such parameters as the amount of fluid drunk (r=-0.966, p<0.05), as well as the level of depression and stress (r=-0.990, p<0.05 and r=-0.953, p<0.05). Conclusions. The results obtained indicate that patients with increased levels of stress and depression are characterized by a decrease in the temperature sensitivity threshold of the gastric mucosa, which in turn leads to symptoms of functional dyspepsia.

Objective : to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods : 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results : in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion : patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.

Abstract. Introduction. Currently, the use of electronic cigarettes is becoming the most popular with and widespread among young people. In Russia, one third of electronic cigarettes consumers are people aged 18 to 29 years. The impact of vaping on various body organs and systems is still understudied now. The aim of our study is to investigate the acid-forming and motor functions of the stomach in people consuming electronic cigarettes. Materials and methods. The study involved 54 people, of which 27 were consumers of electronic cigarettes, all without any diagnosed organic diseases in their digestive systems. The severity of gastroenterological symptoms was assessed using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire, while motor and acid-forming functions of the stomach were assessed according to pH-impedance measurements. The findings were processed statistically using nonparametric tests with the Microsoft Office Excel 2013 and Statistica 10.0 computer programs. Results and discussions. Vaping participants had significantly more gastrointestinal symptoms according to the Gastrointestinal Symptom Rating Scale as compared to their non-smoking peers. In the group of subjects consuming electronic cigarettes, there was a greater number of pathological gastroesophageal refluxes and increased acidity in the lower esophagus and stomach as compared to the control group. Conclusions. Our findings indicate the adverse effects provided by electronic cigarettes on the functional activity of the upper gastrointestinal tract.

The article describes a clinical case of successful treatment of COVID-19 in a patient who previously underwent lung transplantation due to cystic fibrosis.

Introduction. The high prevalence of functional dyspepsia in the population requires detailing the mechanisms of its development with the definition of the role of hormones of the gastrointestinal tract in the development of clinical symptoms. Purpose of the study: to clarify the pathogenetic role of cholecystokinin in functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22.3 ± 0.17 years, divided into 3 groups, was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. The participants of the study were questioned according to the GSRS questionnaire, their anthropometric data, the concentration of cholecystokinin in the blood before and after the drinking test were determined. Statistical processing included calculation of means, their errors, Mann-Whitney U-test for independent samples and Wilcoxon W-test for related samples, Spearman’s rank correlation test. Results. Patients with EPS are characterized by a statistically significantly greater severity of abdominal pain syndrome (4.33 ± 0.51 points) than those suffering from PDS (2.47 ± 0.38 points) and healthy people (2.19 ± 0.22 points). Dyspeptic syndrome is more typical for patients with PDS (2.07 ± 0.12 points) than those with EPS (1.10 ± 0.04 points). Patients with PDS are characterized by higher values of height, hip volume, lean mass, waist to hip ratio than patients with EPS. The concentration of cholecystokinin in the blood on an empty stomach in patients with EPS (213.37 ± 14.35 pg/ml) is statistically significantly higher than in those examined with PDS (129.45 ± 10.44 pg/ml) and healthy people (146.99 ± 5.17 pg/ml). The level of cholecystokinin in the blood after water exercise in patients with PDS increased statistically significantly to 176.14 ± 8.16 pg/ml, with EPS – decreased to 187.98 ± 7.26 pg/ml. Correlations between the magnitude of cholecystokininemia and the main anthropometric data in EPS and PDS are multidirectional. Conclusion. Cholecystokinin plays an important role in the pathogenesis of gastroduodenal motility disorders in patients with functional dyspepsia.

Purpose of the study: to clarify the effect of the concentration of motilin in the blood on the clinical symptoms of functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22,3±0,17 years was carried out, divided into 3 groups: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. All subjects were questioned according to the GSRS questionnaire, and the concentration of motilin in their blood was determined before and after the drinking test. Statistical processing included the calculation of mean values, their errors, Student’s t-test, Pearson’s correlation test, factor analysis. Results. In patients with PDS, the intensity of abdominal pain (2,47±0,38 points) does not differ from healthy ones (2,19±0,22 points), in patients with EPS it is higher (4,33±0,51 points). Dyspeptic syndrome is more typical for patients with PDS (2,07±0,12 points) than for EPS (1,10±0,04 points). The concentration of motilin in the blood on an empty stomach with PDS (9605,47±167,64 pg/ml) is higher than with EPS (8780,67±232,27 pg/ml). After the drinking test, the level of motilin in the blood of patients with EPS increased to 9367,33±145,78 pg/ml, the PDS decreased to 9323,33±239,04 pg/ml. With PDS, the severity of reflux syndrome directly correlates with the concentration of motilin in the blood. In EPS, the initial level of motilin correlates inversely with the severity of reflux syndrome, constipation syndrome, and the volume of water drunk. After the drinking test, there is an inverse correlation between the level of motilin and the severity of diarrheal and dyspeptic syndromes, and a direct correlation with the intensity of abdominal pain. The initial level of motilin in the blood brings the greatest factor load into the “factor of motor disorders”. Conclusion. The initial level of motilin and its dynamics during water load play an essential role in the formation of the clinical picture of functional dyspepsia.

Functional dyspepsia is the actual problem of modern gastroenterology, its manifestations contribute to the lifting of lifestyle and nutrition. However, a comprehensive assessment of the effect of violations of food behavior, the distribution of adipose tissue and the level of gosters regulating appetite on the severity of gastroenterological symptoms in individuals with various types of functional dyspepsia hasn't been carried out yet. Aim - to clarify the effect of food behavior, ghrelin and leptin blood concentrations on clinical symptoms in patients with different types of functional dyspepsia. Material and methods. A prospective study with the participation of 90 people aged 22.3±0.2, divided into 3 groups was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), and practically healthy. All respondents were interviewed using the GSRS, DEBQ questionnaires, their anthropometric data have been defined, body composition indicators were calculated based on the measurement of body circumference measurements, leptin and ghrelin concentration in blood serum was measured by the enzyme immunoassay method. Results and discussion. EPS was characterized by more pronounced symptoms (10.10±0.32 points on the GSRS questionnaire) due to abdominal pain syndrome (4.33±0.51 points) compared with patients with PDS and healthy individuals. In both variants of the functional dyspepsia, all three types of food behavior disorders were revealed, however, the external type was more characteristic for PDS. Patients with PDS had a larger volume of visceral adipose tissue (42.84% of the total fat tissue in the body) than those with EPS (34.02%) and healthy ones (35.55%). Blood leptin concentration in patients with both variants of the functional dyspepsia was lower (especially in patients with EPS - 0.17±0.03 ng/ml, p=0.039) than in healthy (0.32±0.08 ng/ml). Ghrelin level in patients with EPS (14.91±0.17 ng/ml) was significantly higher than in healthy (11.55±0.44 ng/ml, p=0.022). Factor analysis made it possible to identify the stress factor showing the connection of emotional disorders of food behavior with increasing gastrointestinal symptoms and blood leptin concentration and decreasing blood ghrelin level. Conclusion. Different variants of functional dyspepsia are characterized by their own peculiarities of eating behavior, the distribution of fat in the body, the degree of changes in leptin and ghrelin levels, which determine their clinical symptoms. The identification and accounting of these factors will make it possible to individualize the approach to the curation of patients with functional dyspepsia.

Introduction. The currently known prognostic criteria for biological therapy have limitations and have not been widely used in clinical practice.Aim. Find predictors of the effectiveness of biological therapy with infliximab in patients with ulcerative colitis.Materials and methods. The object of the study was patients (n = 52) diagnosed with Ulcerative Colitis in the active form of the disease, including 27 men and 25 women undergoing therapy with infliximab. Follow-up was carried out for three years from the start of therapy. The age of the examined persons ranged from 19 to 64 years (mean age 34.76 ± 2.13 years). The mean score on the Mayo scale was 6.1 ± 3.49.Results. In the course of our study, we obtained the following data on the effectiveness of infliximab therapy in patients with severe ulcerative colitis: a significant improvement in the dynamics of laboratory and instrumental parameters was recorded in 25 people (43.8%); the onset of stable clinical remission — in 15 people (26.3%); disease progression — in 5 cases (8.7%); lack of dynamics or a less pronounced effect — in 12 cases (21.2%).Conclusions. We have identified a system of clinical and laboratory factors that make it possible to predict the effectiveness of biological therapy with infliximab in patients with ulcerative colitis. The mathematical model in the form of a discriminant function makes it possible to divide patients into groups depending on the possible effect of the use of biological therapy with infliximab before its initiation (the sensitivity of the model is 83.3%, the specificity is 71.4%).

The purpose — to assess the effectiveness of therapeutic use of «Uvinskaya» natural mineral water for Helicobacter Pylori eradication in patients with chronic gastritis and type 2 diabetes mellitus. Material and methods. The study included 120 patients with type 2 diabetes mellitus, who were diagnosed with chronic gastritis associated with Helicobacter Pylori. The average age of patients was 61.6 ± 4.13 years, the duration of diabetes — from 2 to 15 years (on average – 9.9 ± 2.5 years), gender composition — 21 men and 99 women. The patients were divided into two groups by simple randomization. In the first group (n = 60), the first line eradication therapy was carried out according to Maastricht V recommendations, in the second group (n = 60) underwent eradication therapy combined with «Uvinskaya» mineral water. The diagnosis of «chronic gastritis» was histologically verified in all patients. The eradication control was carried out 4 weeks after therapy. Changes in the severity of gastroenterological symptoms in patients were determined by the Gastrointestinal Symptom Rating Scale questionnaire. Statistical processing was carried out with the calculation of average values and standard errors of the average. The differences were considered reliable at p ≤ 0.05. Results. The study shows the positive effect of the «Uvinskaya» mineral water inclusion into the Helicobacter Pylori eradication treatment complex in patients with type 2 diabetes mellitus: the condition of patients improved, inflammatory changes in the stomach mucosa were reduced and the efficiency of eradication therapy increased. Conclusion. The amplification of the positive therapeutic effects of drug treatment and drinking balneotherapy provides a significant increase in the efficiency of eradication, improving the clinical course and forecast of chronic gastritis associated with Helicobacter Pylori in patients with type 2 diabetes mellitus. It enables to recommend the intake of «Uvinskaya» mineral water as part of eradication therapy in patients with type 2 diabetes mellitus.

The article presents modern views on the problem of gastroesophageal reflux disease (GERD). Data on the prevalence and risk factors for the development of the disease are presented. Emphasis is placed on the special role of slightly acidic and slightly alkaline reflux in the pathogenesis of GERD, which, in combination with dysfunction of the lower esophageal sphincter and impaired motor-evacuation function of the stomach, are important factors, determining the the lack of effectiveness of standard antisecretory therapy. The exceptional importance of the 24-hour pH impedanceometry method is emphasized for the differential diagnosis of the non-erosive form of GERD with functional heartburn and hypersensitivity of the esophagus to reflux (the so-called hypersensitive esophagus). The data of the results of domestic and foreign studies devoted to the evaluation of the effectiveness of the use of physiotherapeutic methods and drinking balneotherapy in patients with GERD are given.

Primary hyperparathyroidism (PGPT) is an endocrine disease characterized by excessive secretion of parathyroid hormone (PTH) in upper — normal or elevated blood calcium levels due to primary parathyroid gland pathology (osch). Primary hyperparathyrosis, depending on the clinical manifestations, can occur in the normocalcemic, mild and manifest form. This article presents a clinical case of the development of the manifest form by the type of visceral disorders. Which appeared in the form of pathology of the gastrointestinal tract. This form of the disease is an indication for surgical treatment and further correction of calcium-phosphorus metabolism.

The aim. To study the quality of life and psychoemotional state of patients with non-alcoholic fatty liver disease against the background of primary hypothyroidism during the use of ethylmethylhydroxypyridine succinate.Materials and methods. 111 patients with non-alcoholic fatty liver were examined, among them 35 were without thyroid dysfunction, 55 with compensated primary hypothyroidism, 21 with decompensated hypothyroidism. The patients underwent general clinical, biochemical, enzyme-linked immunosorbent assays of blood, instrumental studies, testing according to psychological questionnaires.Results. With decompensation of hypothyroidism, a statistically significant increase in indicators of depression, situational and personal anxiety was revealed in comparison with patients without hypothyroidism. The examined patients showed an increase in the level of situational and personal anxiety. The presence of hypothyroidism in the examined patients significantly worsens these indicators, leading to an increase in the degree of anxiety, aggravated by decompensation of hypothyroidism. A positive dynamic was revealed in the correction of the psychoemotional status of patients in the observation group during the complex treatment with ethylmethylhydroxypyridine succinate: the severity of depression, situational and personal anxiety, manifestations of dyspeptic and reflux syndromes decreased.Conclusion. Hypothyroidism affects the quality of life and psycho-emotional state of patients with non-alcoholic fatty liver disease: it worsens the degree of depression, situational and personal anxiety. The addition of ethylmethylhydroxypyridine succinate to standard therapy with sodium levothyroxine in patients with non-alcoholic fatty liver disease in the setting of hypothyroidism improves the quality of life and psycho-emotional state.

The study aimed to determine the predictive capabilities of the Gastrointestinal Symptom Rating Scale (GSRS) for assessing the effectiveness of eradication therapy in Helicobacter pylori (HP) infected patients with type 2 diabetes mellitus. The study involved 60 patients of both sexes with a diagnosis of type 2 diabetes mellitus and chronic HP-associated gastritis, the average age of patients was 61.9 years, average duration of type 2 diabetes was 10.1 years. For statistical analysis of the data, we used the method of constructing ROC curves, which allowed us to identify prognostic factors (in this case, gastroenterological syndromes, such as abdominal pain, refl ux, indigestion, diarrhea and constipation) that influence the effectiveness of eradication therapy in patients with type 2 diabetes. It was found that high values of refl ux and indigestion syndromes scales of the GSRS are associated with the probability of low eradication therapy response in patients with type 2 diabetes, i.e. these syndromes can act as complicating factors for the elimination of Helicobacter pylori. The obtained data suggest the need for screening diagnostics of Helicobacter pylori, clinical manifestations of gastrointestinal pathology and subsequent etiological and pathogenetic treatment.