Introduction Atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD) are common chronic pediatric conditions with significant impacts on quality of life involving sleep disturbance and development. Studies have reported co-occurrence of AD and ADHD but have not investigated the association of longitudinal AD phenotypes with ADHD. Methods Analyses were conducted using the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort. AD longitudinal phenotypes including “Early” (at age 2 years), “Late” (at 10 years), and “Persistent” (at age 2 and 10 years) were diagnosed at respective clinic visits. ADHD diagnosis was parental-reported doctor diagnosis. The association between longitudinal AD phenotypes and ADHD was evaluated using robust Poisson regression adjusted for potential confounders to calculate adjusted risk ratios (aRR). Results Relative to never AD, there was no significant association between early, late, or persistent AD and ADHD (aRR 1.08, 95% CI (0.59, 1.98), p=0.80; aRR 1.36, 95% CI (0.77, 2.39); p=0.29; aRR 0.95, 95 % CI (0.48, 1.89), p=0.89, respectively). Sex and race did not modify any of these associations. Conclusion In contrast to prior reports of co-occurrence of AD and ADHD, we did not find an association between longitudinal AD phenotypes and ADHD by age 10 years. Future studies are needed to identify whether associations with ADHD may be limited to those with severe or uncontrolled AD.

Several reports indicate that infant daycare attendance is associated with lower allergy risk. We assessed whether daycare by one month of age was associated with IgE levels, allergen sensitization, and allergic rhinitis among children in a southeast Michigan birth cohort.

Idiopathic systemic capillary leak syndrome (SCLS) is a rare disorder characterized by episodic loss of vascular endothelial integrity resulting in massive third-spacing and hallmark hypotension, hypoalbuminemia, and hemoconcentration. With approximately 300 patients reported in the literature, the SCLS phenotype continues to expand as new cases emerge. Here we report a case of SCLS preceded by recurrent volvulus.

Chronic idiopathic urticaria (CIU) is pruritic, transient hives that last for at least six consecutive weeks. Guidelines recommend step-wise approach to treatment with step 4 treatment including starting omalizumab. We present a case of serum sickness-like reaction in a pediatric patient with chronic urticaria treated with omalizumab.