Background. There are different opinions about the effect of functional ovarian cysts on the duration of controlled ovarian hyperstimulation, the dose of gonadotropins, the number and quality of collected oocytes and produced embryos, and the frequency of pregnancy. Aim. To analyze in vitro fertilization (IVF) programs in women with anovulatory infertility and ovarian retention. Materials and methods. A prospective study included 71 women aged 18–44 years. The main group (I) included patients ( n = 38) with anovulatory infertility and functional ovarian cysts (FOC) diagnosed by ultrasound before enrollment in the IFV program. Patients of this group underwent ultrasound-guided transvaginal puncture of ovarian cyst followed by cytology. The comparison group (II) ( n = 33) encompassed patients with anovulatory infertility without FOC, who went through the IVF program. The control group (III) included apparently healthy individuals ( n = 15). The study algorithm included collection of clinical and anamnestic data of the patients, data of laboratory and instrumental studies, parameters of a stimulated IVF cycle, characteristics of oogenesis and early embryogenesis, and assessment of IVF program effectiveness. Conclusion. It was established that in FOC and anovulatory infertility, the number of collected oocytes was smaller; however, the number of the best quality embryos and the frequency of pregnancy did not differ.

In the model experiment on rats in order to verify the lunasensor theory of brain aging by methods of light microscopy in the hypothalamus, responsible for the aging mechanisms, biorhythms, homeostasis and reproduction, the pineal gland, as well as in the organs related to them on the system-level, the morphological markers of moonphasal changes are studied for the first time. Concluded possible enhancement of the hypothalamic-pituitary-gonadal axis, glycogenolysis, water and electrolyte metabolism and cardiac activity on the full moon, and of the pacemakers biological rhythms - suprachiasmatic nuclei of the hypothalamus and pineal gland, the tone of the parasympathetic division of the autonomic nervous system, insulin secretion and insulin-like proteinthe on the new moon.

Using electron microscopy and morphometric analysis studied the structural changes of neurons and radial glia of the retina of white mongrel male rats when exposed to light (6000 lux) in the dynamics after 1, 7, 14 and 30 days. The proposed mathematical model has allowed a high degree of probability to assess the state of a pool of cells of the retina at specific times throughout the experiment. The most striking structures of the retina are neurosensory cells, and neurons of theinner retinal layers are less sensitive to these influences.

On the original experimental model of autoimmune oophoritis the stages of formation and extent of destruction to structural elements of the ovary were studied, using histological and histochemical methods, the content antiovarian antibodies in the serum of experimental animals by enzyme immunoassay was determined. Autoimmune oophoritis is the step-wise character, with a gradual increase in the pathological process, which is manifested in the growth of mononuclear infiltration, restructuring steroid-producing structures, destruction of oocytes.

On the basis the analysis of morphometric data are revealed the special features of the functional state of pineal gland in mice with the delay of sexual ripening. Is made conclusion about the involvement of pinealocytes into the regulation of reproduction.