Abstract Discussion Points What should the absolute sterechemistry of the oxazolidinone benzyl group of compound 1 be in order to furnish the required product 2 under the conditions reported? Suggest a structure for compound 6. Rationalise the stereoselectivity observed in step g. What is the mechanism of the Martin sulfurane step k leading to compound 11?

The intramolecular nitrone dipolar cycloaddition of N-alkenylnitrone has been utilised in approaches to the synthesis of a family of indolizidines such as castanospermine and a tethered swainsonine analogue. Examples of a tandem hydroxylamino-alkyne cyclisation/dipolar trapping experiment in the synthesis of (+/-)-adaline and (+/-)-euphococcinine are outlined.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

PUBLISHED information on the results of investigation of the toxic and narcotic activity of fluorocarbons is very scanty, and such as is available is probably invalidated because of the lack of purity of the samples used in the tests. Struck and Plattner1, who examined C4F10, C5F10 and C6F12, concluded that the materials were toxic, whereas Spiegl2 used concentrations of C7F16 and C8F16 which were too low to acquit them of toxic properties. He fotind C7F14, of unspecified purity, to be toxic.

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THE physical and chemical properties of selenium hexafluoride have received little investigation1,2. We have prepared selenium hexafluoride by reaction of the elements at 300° C. in a copper tube, and found that, provided steps are taken to return selenium tetrafluoride (boiling point, 106° C.) to the reaction zone, a yield of more than 90 per cent selenium hexafluoride is readily obtained. The gas was condensed in a trap cooled to − 160° C. and afterwards sublimed into an aspirator. The greater part of the small amount of selenium tetrafluoride collected remained in the trap after the selenium hexafluoride had sublimed. The product was scrubbed with 10 per cent sodium hydroxide solution, condensed in liquid air, and transferred to an evacuated steel cylinder cooled in ‘Drikold’.

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Fredenhagen and Krefft1 have shown that, when molten KF.HF is electrolysed using a graphite anode, the anode is not ‘wetted’ by the electrolyte. The same effect has been noted by other investigators as, for example, Cady2.

IN the course of an investigation of the oxides of rhenium in progress in these laboratories, we have sought to repeat the preparation of the highest oxide described by I. and W. Noddack,1 Re2O8, which was obtained by them on heating the heptoxide below 150° in a stream of oxygen. The yellow heptoxide used in the Noddacks' preparations melted at 220° and gave rise to a white sublimate at 150° described as Re2O8 and possessing the property of decolorising acidified potassium permanganate. The melting point of our specimens of heptoxide has invariably been about 300°,2 and this material failed to give any evidence of a white sublimate when heated in a stream of oxygen to temperatures below its melting point. Moreover, quantitative experiments repeatedly showed that its formation was unattended by any increase in weight. The sublimate was identical in crystalline form with the heptoxide, was decidedly yellow, and melted to a yellow solid, also indistinguishable from the heptoxide.

H. V. A. Briscoe, P. L. Robinson and A. J. Rudge, J. Chem. Soc., 1931, 2211 DOI: 10.1039/JR9310002211