This chapter presents the study that directly measured local cerebral glucose use by positron emission tomography (PET) with simultaneous recording of EEG from 16 electrodes spaced over the left hemisphere to maximize spatial resolution. Simultaneous cerebral glucography with positron emission tomography and topographic quantitative electroencephalography is carried out in six normal volunteers. The presence of resting occipital alpha activity is associated with relatively low glucose use consistent with the phenomenon of alpha blocking with visual input. Higher EEG amplitude is associated with higher glucose use in some posterior and central regions. The harmlessness, repeatability, and low cost of EEG topography give it some advantages over the high cost of PET or isotopic regional blood flow techniques. Extended studies are further necessary to define regional relationships; simultaneous PET and EEG studies are able to better characterize metabolic information available in the scalp electrical activity.