This study aims to carry out the extraction and isolation of bioactive compounds from the peel of Punica Granatum Linn and investigate the wound healing activity of isolated compounds. Soxhlet extraction of P. Granatum peel powder was done with ethanol as solvent. The isolation of phytochemical constituents, Punicalin and Punicalagin present in the obtained extract, was done with the help of column chromatography using n-butanol and ethyl acetate fractions. The column was packed with silica gel, and 100-200 mesh was used as a stationary phase separately at different stages of the isolation process. All fractions obtained from column chromatography were subjected to HPLC, LCMS, FTIR, 1HNMR studies to identify and confirm the obtained isolated bioactive. The study was further extended to assess the wound healing activity of isolated punicalin and punicalagin by using in vitro excision and incision models. The activity of prepared alcoholic extract and isolated bioactive was compared to standard 10 % w/w povidone-iodine ointment. The highest wound healing strength observed was 201.83 ± 4.98 for isolated 10% w/w punicalagin ointment in the incision wound model. Also, in the excision wound model, the highest % reduction in the wound was observed on the 15th day as 88 ± 0.78, which was optimum compared to the standard with a % reduction in the wound as 92 ± 0.91. As a result, bioactive punicalagin and punicalin obtained from methanol extract of Punica Granatum peel powder can be used as potent phytoconstituents and wound healing agents for pharmaceutical preparations

Despite evidence for the efficacy of UFE and the documented long-term morbidity of hysterectomy, the treatment is largely underutilized and the majority of women with fibroids in the US undergo hysterectomy. We aim to analyze the quality and presence of bias in YouTube videos regarding treatment of fibroids and uterine fibroid embolization.

To examine preference for radial or femoral access for visceral arterial interventions among nursing staff responsible for post procedural care. In September 2018, 100 surveys were sent to nurses in the cardiac and interventional radiology recovery unit, 48 of whom completed the survey. On a 5-point Likert scale, nurses responded to whether they disagree or agree with 10 encouraging statements regarding radial arterial access (Table 1). An average of these 10 scores was calculated and an average score >/= 4 for a nurse was considered to be favorable for radial access. Based on their years of experience, nurses were categorized into "more experienced" or "less experienced" if they had more than or less than 10 years of experience, respectively. Surveyed nurses had an average of 16.7 years of experience with a standard deviation of 10.2 years. The median value for 9 out of 10 statements regarding radial access was a 5; the median value was a 4.5 for the statement "Radial access requires less nursing care." Nurses responded most favorably to the statements "Radial access is less embarrassing" and "Radial access lets patients go home sooner," with 93% (43/47) of nurses either strongly agreeing or agreeing. Among the 48 nurses, 40 nurses had a cumulative average score >/= 4. A chi-square test of radial favorability vs. level of experience yielded a chi-square statistic of 1.2 and a p-value of 0.273 (not significant at p <0.05). Nurses tend to prefer radial over femoral access when caring for patients who have undergone interventional radiology procedures, independent of years of experience. Nursing care is not likely be an impediment to the initiation of a radial access program.Table 1Radial Access QuestionnaireRadial access is more comfortable.Radial access causes less pain.Radial access is less embarrassing.Radial access is more convenient.Radial access has fewer vascular complications.Radial access has fewer bleeding complications.Radial access lets patients go home sooner.Radial access requires less nursing care.Radial access allows for easier nursing monitoring.Radial access is better for patient care. Open table in a new tab

BACKGROUND:Food allergy is estimated to affect 3-4% of adults in the US, but there are limited educational resources for primary care physicians. The goal of this study was to develop and pilot a food allergy educational resource based upon a needs survey of non-allergist healthcare providers. METHODS:A survey was undertaken to identify educational needs and preferences for providers, with a focus on physicians caring for adults and teenagers, including emergency medicine providers. The results of the survey were used to develop a teaching program that was subsequently piloted on primary care and emergency medicine physicians. Knowledge base tests and satisfaction surveys were administered to determine the effectiveness of the educational program. RESULTS:Eighty-two physicians (response rate, 65%) completed the needs assessment survey. Areas of deficiency and educational needs identified included: identification of potentially life-threatening food allergies, food allergy diagnosis, and education of patients about treatment (food avoidance and epinephrine use). Small group, on-site training was the most requested mode of education. A slide set and narrative were developed to address the identified needs. Twenty-six separately enrolled participants were administered the teaching set. Pre-post knowledge base scores increased from a mean of 38% correct to 64% correct (p < 0.001). Ability to correctly demonstrate the use of epinephrine self injectors increased significantly. Nearly all participants (>95%) indicated that the teaching module increased their comfort with recognition and management of food allergy. CONCLUSION:Our pilot food allergy program, developed based upon needs assessments, showed strong participant satisfaction and educational value.

•  National and international consensus bodies have identified asthma education and guided self-management as essential components of efforts to empower patients and reduce asthma morbidity and mortality (1–6). •  Asthma self-management cannot be achieved without appropriate asthma education (7). •  Asthma self-management education improves outcomes in asthma (7). •  Self-management requires effective communication among physician, patient, and those who care for the patient (8). •  Self-management goals and programs must be individualized to the needs, desires, abilities, and socioeconomic situation of the patient. •  Each interaction with the patient can be an opportunity to deliver and reinforce self management messages. •  Education or information must be combined with plans for self-management to be maximally effective (9). •  Patient nonadherence is a complex and pervasive problem that requires assessment and efforts to manage the psychological issues related to asthma (8). •  Asthma self-management started in asthma camps but has entered new venues, including schools, doctors’ offices, emergency rooms, hospitals, HMO disease management groups, and communities. •  The Internet allows physicians and patients to gather information regarding asthma and self-management resources that is available at the local and national levels.

Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis.

Anaphylaxis is a source of anxiety for patients and healthcare providers. It is a medical emergency that presents with a broad array of symptoms and signs, many of which can be deceptively similar to other diseases such as myocardial infarction, asthma, or panic attacks. In addition to these diagnostic challenges, anaphylaxis presents management difficulties due to rapid onset and progression, lack of appropriate self-treatment education and implementation by patients, severity of the allergic response, exacerbating medications or concurrent disease, and unpredictability. The most common causes of anaphylaxis are food allergies, stinging insects and immunotherapy (allergy shots) but idiopathic anaphylaxis, latex allergy and drug hypersensitive all contribute to the epidemiology. Reactions to IVP and other dyes are coined anaphylactoid reactions but have identical pathophysiology and treatment, once the mast cell has been degranulated. As many antigens can be the trigger for fatal anaphylaxis, it is useful to examine the features of each etiology individually, highlighting factors common to all fatal anaphylaxis and some specific to certain etiologies. Generally what distinguishes a fatal from non fatal reaction is often just the rapidity to apply correct therapy. Prevention is clearly the key and should identify high-risk patients in an attempt to minimize the likely of a severe reaction. Although fatal anaphylaxis is rare, it is likely underreported.

Intensity and Temperature Dependence of Steady-State Photoconductivity Down to 8 K and DOS Distribution Obtained from These Measurements in a-Si:H was published in Volume 85, Number 1 September 16, 1984 on page 297.