N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells. In addition, caveolin-1 mediates the suppressive function of NDRG1 in epithelial–mesenchymal transition, migration and invasion in vitro and metastasis in vivo. These results help to fulfill the potential mechanisms of NDRG1 in anti-metastatic treatment for human colorectal cancer.

The BaBar detector operated successfully at the PEP-II asymmetric e+e− collider at the SLAC National Accelerator Laboratory from 1999 to 2008. This report covers upgrades, operation, and performance of the collider and the detector systems, as well as the trigger, online and offline computing, and aspects of event reconstruction since the beginning of data taking.

The authors report a highly efficient thiophosphoramidate bifunctional catalyst 1a based on the pyrrolidine backbone for the Michael reaction of ketones to nitroolefins. Various nitro-olefins are tolerated with excellent diastereoselectivity and enantioselectivity. Inferior catalytic performance was observed by using an oxo analogue 1b which might be related to its acidity.

We present preliminary measurements of branching fractions and charge asymmetries for the B meson decays B → η(′)K∗, B → η(′)ρ, and B+ → η′π+. The data were recorded with the BABAR detector at PEP-II and correspond to 89 × 106 BB pairs produced in e+e− annihilation through the Υ (4S) resonance. We find the branching fractions B(B0 → ηK∗0) = (19.0 −2.1 ± 1.3) × 10−6, B(B+ → ηK∗+) = (25.7 −3.6±1.8 )×10−6, B(B+ → ηρ+) = (10.5 −2.8±1.3)×10, B(B+ → η′ρ+) = (14.0 −4.6 ± 1.9)× 10−6 (< 22× 10−6 with 90% confidence), and B(B+ → η′π+) = (2.8 −1.0 ± 0.3)× 10−6 (< 4.5×10−6). We also set 90% CL upper limits of B(B0 → η′K∗0) < 6.4×10−6 and B(B+ → η′K∗+) < 12×10−6. The time-integrated charge asymmetries are Ach(ηK) = +0.03±0.11±0.02, Ach(ηK) = +0.15 ± 0.14 ± 0.02, and Ach(ηρ) = +0.06 ± 0.29 ± 0.02. Contributed to the XXIst International Symposium on Lepton and Photon Interactions at High Energies, 8/11 — 8/16/2003, Fermilab, Illinois USA Stanford Linear Accelerator Center, Stanford University, Stanford, CA 94309 Work supported in part by Department of Energy contract DE-AC03-76SF00515. The BABAR Collaboration, B. Aubert, R. Barate, D. Boutigny, J.-M. Gaillard, A. Hicheur, Y. Karyotakis, J. P. Lees, P. Robbe, V. Tisserand, A. Zghiche Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France A. Palano, A. Pompili Università di Bari, Dipartimento di Fisica and INFN, I-70126 Bari, Italy J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu Institute of High Energy Physics, Beijing 100039, China G. Eigen, I. Ofte, B. Stugu University of Bergen, Inst. of Physics, N-5007 Bergen, Norway G. S. Abrams, A. W. Borgland, A. B. Breon, D. N. Brown, J. Button-Shafer, R. N. Cahn, E. Charles, C. T. Day, M. S. Gill, A. V. Gritsan, Y. Groysman, R. G. Jacobsen, R. W. Kadel, J. Kadyk, L. T. Kerth, Yu. G. Kolomensky, J. F. Kral, G. Kukartsev, C. LeClerc, M. E. Levi, G. Lynch, L. M. Mir, P. J. Oddone, T. J. Orimoto, M. Pripstein, N. A. Roe, A. Romosan, M. T. Ronan, V. G. Shelkov, A. V. Telnov, W. A. Wenzel Lawrence Berkeley National Laboratory and University of California, Berkeley, CA 94720, USA K. Ford, T. J. Harrison, C. M. Hawkes, D. J. Knowles, S. E. Morgan, R. C. Penny, A. T. Watson, N. K. Watson University of Birmingham, Birmingham, B15 2TT, United Kingdom T. Held, K. Goetzen, H. Koch, B. Lewandowski, M. Pelizaeus, K. Peters, H. Schmuecker, M. Steinke Ruhr Universität Bochum, Institut für Experimentalphysik 1, D-44780 Bochum, Germany N. R. Barlow, J. T. Boyd, N. Chevalier, W. N. Cottingham, M. P. Kelly, T. E. Latham, C. Mackay, F. F. Wilson University of Bristol, Bristol BS8 1TL, United Kingdom K. Abe, T. Cuhadar-Donszelmann, C. Hearty, T. S. Mattison, J. A. McKenna, D. Thiessen University of British Columbia, Vancouver, BC, Canada V6T 1Z1 P. Kyberd, A. K. McKemey Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom V. E. Blinov, A. D. Bukin, V. B. Golubev, V. N. Ivanchenko, E. A. Kravchenko, A. P. Onuchin, S. I. Serednyakov, Yu. I. Skovpen, E. P. Solodov, A. N. Yushkov Budker Institute of Nuclear Physics, Novosibirsk 630090, Russia D. Best, M. Bruinsma, M. Chao, D. Kirkby, A. J. Lankford, M. Mandelkern, R. K. Mommsen, W. Roethel, D. P. Stoker University of California at Irvine, Irvine, CA 92697, USA C. Buchanan, B. L. Hartfiel University of California at Los Angeles, Los Angeles, CA 90024, USA

D.S. Akerib, M.S. Armel-Funkhouser, M.J. Attisha, C.N. Bailey, L. Baudis, D.A. Bauer, P.L. Brink, R. Bunker, B. Cabrera, D.O. Caldwell, C.L. Chang, M.B. Crisler, P. Cushman, M. Daal, R. Dixon, M.R. Dragowsky, D.D. Driscoll, L. Duong, R. Ferril, J. Filippini, R.J. Gaitskell, R. Hennings-Yeomans, D. Holmgren, M.E. Huber, S. Kamat, A. Lu, R. Mahapatra, V. Mandic, J.M. Martinis, P. Meunier, N. Mirabolfathi, H. Nelson, R. Nelson, R.W. Ogburn, T.A. Perera, M.C. Perillo Issac, E. Ramberg, W. Rau, A. Reisetter, R.R. Ross, 11, ∗ T. Saab, B. Sadoulet, 11 J. Sander, C. Savage, R.W. Schnee, D.N. Seitz, B. Serfass, K.M. Sundqvist, J-P.F. Thompson, G. Wang, S. Yellin, 7 and B.A. Young (CDMS Collaboration) Department of Physics, Case Western Reserve University, Cleveland, OH 44106, USA Department of Physics, University of California, Berkeley, CA 94720, USA Department of Physics, Brown University, Providence, RI 02912, USA Department of Physics, University of Florida, Gainesville, FL 32611, USA Fermi National Accelerator Laboratory, Batavia, IL 60510, USA Department of Physics, Stanford University, Stanford, CA 94305, USA Department of Physics, University of California, Santa Barbara, CA 93106, USA School of Physics & Astronomy, University of Minnesota, Minneapolis, MN 55455, USA Department of Physics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80217, USA National Institute of Standards and Technology, Boulder, CO 80303, USA Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA Department of Physics, Santa Clara University, Santa Clara, CA 95053, USA (Dated: February 5, 2008)

Based on 88 million Υ (4S) → BB decays collected by the BABAR experiment at the PEPII asymmetric-energy B factory at SLAC, we report preliminary results of four analyses which investigate semileptonic charmless B decays, B → Xulν̄. Deeper understanding of all aspects of these decays will improve the determination of the Cabibbo-Kobayashi-Maskawa matrix element |Vub|. In events in which one B meson decay to a hadronic final state is fully reconstructed, the semileptonic decay of the second B meson is identified by the detection of a charged lepton. By measuring the spectrum of the invariant mass of the hadronic system Xu (MX), we derive the branching fraction B(B → Xulν̄) = (2.53 ± 0.29(stat.) ± 0.26(sys.) −0.41(theo.)) × 10−3. The two-dimensional distribution of MX and q 2, the squared lepton-neutrino invariant mass, is used to derive the partial branching fraction for MX < 1.7GeV/c 2, q2 > 8GeV2/c4 to be ∆B(B → Xulν̄) = (0.88 ± 0.14(stat.) ± 0.13(sys.) ± 0.02(theo.)) × 10−3. From these two measurements we can extract |Vub| = (4.77 ± 0.28(stat.) ± 0.25(sys.) −0.39(theo.)) × 10−3 and |Vub| = (4.92 ± 0.39(stat.) ± 0.36(sys.) ± 0.46(theo.)) × 10−3, respectively. We use the same sample to extract the true MX distribution for B → Xulν̄ events, with the goal of comparing it with theoretical models. We also identify several exclusive charmless semileptonic B decays, and measure the branching fractions B(B → πlν) = (1.08 ± 0.28(stat.) ± 0.16(sys.)) × 10−4 and B(B → ρlν) = (2.57 ± 0.52(stat.) ± 0.59(sys.)) × 10−4 using isospin and quark model constraints. We also set limits on B(B− → ηlν̄ ), B(B− → ηlν̄ ), B(B− → a0lν̄ )B(a0 → ηπ0), and B(B0 → a0 lν̄ )B(a0 → ηπ+). Submitted to the 32nd International Conference on High-Energy Physics, ICHEP 04, 16 August—22 August 2004, Beijing, China Stanford Linear Accelerator Center, Stanford University, Stanford, CA 94309 Work supported in part by Department of Energy contract DE-AC03-76SF00515. The BABAR Collaboration, B. Aubert, R. Barate, D. Boutigny, F. Couderc, J.-M. Gaillard, A. Hicheur, Y. Karyotakis, J. P. Lees, V. Tisserand, A. Zghiche Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France A. Palano, A. Pompili Università di Bari, Dipartimento di Fisica and INFN, I-70126 Bari, Italy J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu Institute of High Energy Physics, Beijing 100039, China G. Eigen, I. Ofte, B. Stugu University of Bergen, Inst. of Physics, N-5007 Bergen, Norway G. S. Abrams, A. W. Borgland, A. B. Breon, D. N. Brown, J. Button-Shafer, R. N. Cahn, E. Charles, C. T. Day, M. S. Gill, A. V. Gritsan, Y. Groysman, R. G. Jacobsen, R. W. Kadel, J. Kadyk, L. T. Kerth, Yu. G. Kolomensky, G. Kukartsev, G. Lynch, L. M. Mir, P. J. Oddone, T. J. Orimoto, M. Pripstein, N. A. Roe, M. T. Ronan, V. G. Shelkov, W. A. Wenzel Lawrence Berkeley National Laboratory and University of California, Berkeley, CA 94720, USA M. Barrett, K. E. Ford, T. J. Harrison, A. J. Hart, C. M. Hawkes, S. E. Morgan, A. T. Watson University of Birmingham, Birmingham, B15 2TT, United Kingdom M. Fritsch, K. Goetzen, T. Held, H. Koch, B. Lewandowski, M. Pelizaeus, M. Steinke Ruhr Universität Bochum, Institut für Experimentalphysik 1, D-44780 Bochum, Germany J. T. Boyd, N. Chevalier, W. N. Cottingham, M. P. Kelly, T. E. Latham, F. F. Wilson University of Bristol, Bristol BS8 1TL, United Kingdom T. Cuhadar-Donszelmann, C. Hearty, N. S. Knecht, T. S. Mattison, J. A. McKenna, D. Thiessen University of British Columbia, Vancouver, BC, Canada V6T 1Z1 A. Khan, P. Kyberd, L. Teodorescu Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom A. E. Blinov, V. E. Blinov, V. P. Druzhinin, V. B. Golubev, V. N. Ivanchenko, E. A. Kravchenko, A. P. Onuchin, S. I. Serednyakov, Yu. I. Skovpen, E. P. Solodov, A. N. Yushkov Budker Institute of Nuclear Physics, Novosibirsk 630090, Russia D. Best, M. Bruinsma, M. Chao, I. Eschrich, D. Kirkby, A. J. Lankford, M. Mandelkern, R. K. Mommsen, W. Roethel, D. P. Stoker University of California at Irvine, Irvine, CA 92697, USA C. Buchanan, B. L. Hartfiel University of California at Los Angeles, Los Angeles, CA 90024, USA S. D. Foulkes, J. W. Gary, B. C. Shen, K. Wang University of California at Riverside, Riverside, CA 92521, USA

The CDMS experiment aims to directly detect massive, cold dark matter particles originating from the Milky Way halo. Charge and lattice excitations are detected after a particle scatters in a Ge or Si crystal kept at similar to 30 mK, allowing to separate nuclear recoils from the dominating electromagnetic background. The operation of 12 detectors in the Soudan mine for 75 live days in 2004 delivered no evidence for a signal, yielding stringent limits on dark matter candidates from supersymmetry and universal extra dimensions. Thirty Ge and Si detectors are presently installed in the Soudan cryostat, and operating at base temperature. The run scheduled to start in 2006 is expected to yield a one order of magnitude increase in dark matter sensitivity.

The published CDMS analyses have used the shape of the phonon signal rising edge to reject low-ionization-yield surface events which produce acoustic phonons more quickly than bulk events do. To achieve better WIMP sensitivity with future larger exposures, we are using a simplified model of phonon production and propagation to construct event position estimators that help us to find more efficient surface event rejection cuts. We describe this model and the resulting new cuts, and summarize the surface event leakage rates and the sensitivity figures of merit of the five surface event rejection methods developed in the second CDMS II Soudan run data analysis.

We present the techniques and results of the calibrations and surface-event rejection cut for the current CDMS-II data set, along with proposals for future analysis of CDMS-II data.

The CDMS-II collaboration's Cold Dark Matter search presently sets the most competitive exclusion limit in the world for the direct detection of the hypothesized Weakly Interacting Massive Particles (WIMPs) that constitute the cold dark matter of the Universe. Our experiment utilizes Ge (and Si) crystals as the target detectors, each with a mass of 250 g (100 g) and cooled to 30 mK. To eliminate natural radioactive sources as background the experiment is conducted in a well-shielded environment in the Soudan Mine, Minnesota, and has been operating for the last two years. To aid in the identification of a possible WIMP-candidate event, the detectors are designed to measure both the ionization and athermal phonon signals produced by each candidate event. The athermal phonon signal is measured using superconducting aluminum films on the crystal surface connected to tungsten transition edge sensors. The latest WIMP-search results from Soudan will be presented, along with projections for the future.

We report new results from the Cryogenic Dark Matter Search (CDMS II) at the Soudan Underground Laboratory. Two towers, each consisting of six detectors, were operated for 74.5 live days, giving spectrum-weighted exposures of 34 (12) kg d for the Ge (Si) targets after cuts, averaged over recoil energies 10-100 keV for a weakly interacting massive particle (WIMP) mass of 60 GeV/c2. A blind analysis was conducted, incorporating improved techniques for rejecting surface events. No WIMP signal exceeding expected backgrounds was observed. When combined with our previous results from Soudan, the 90% C.L. upper limit on the spin-independent WIMP-nucleon cross section is 1.6 x 10(-43) cm2 from Ge and 3 x 10(-42) cm2 from Si, for a WIMP mass of 60 GeV/c2. The combined limit from Ge (Si) is a factor of 2.5 (10) lower than our previous results and constrains predictions of supersymmetric models.

Presently the CDMS-II collaboration's Weakly Interacting Massive Particle (WIMP) search at the Soudan Underground Laboratory sets the most stringent exclusion limits of any WIMP cold dark matter direct-detection experiment. To extend our reach further, to WIMP-nucleon cross-sections in the range 10-46-10-44cm2, we propose SuperCDMS, which would take advantage of a very deep site. One promising site is the recently approved SNOLab facility in Canada. In this paper we will present our overall program and focus on phase A of SuperCDMS.