The aim of this multicentre prospective study was assessing the effectiveness of intravaginal treatment of vaginal candidiasis with Pimafucin 100 mg ovule. Success was obtained among 81% pregnant and 86% nonpregnant women. The negative predictive factors were intensive patients complains: pruritus or soreness.

Cel pracy Terapia raka jajnika stanowi ciągle istotny problem. Leczenie I rzutu jest obecnie klasyczną chemioterapią systemową. Celem pracy jest ocena polączenia terapii systemowej zlozonej z cyklofosfamidu (CTX) – 600 mg/m2, carboplatyną (CBDCA)- 400 mg/m2, epirubicyną (EPi) – 50 mg/m2oraz carboplatyny podawanej dootrzewnowo w dawce 200 mg. Wstepnie oceniono rowniez chemioterapią systemową oraz dootrzewnową zlozoną z taxoidow i carboplatyny w terapii wznowy raka jajnika. Wyniki Do badania zakwalifikowano 27 pacjentek w przedziale wiekowym 47–77 lat, oceniono pod wzgledem odpowiedzi do tej pory 17 chorych, a pod wzgledem toksyczności 27 chorych. Stopien zaawansowania wg FIGO wahal sie od IC stopnia do IV. Ocene prowadzono miedzy lutym 1995 a styczniem 1997. Poddano lącznie 152 kursy chemioterapii z czego jedynie 15 kursow bylo chemioterapią neoadjuwantową, 6 bylo chemioterapia ratującą, a 131 kursow stanowila chemioterapia adjuwantowa. Skutecznośc chemioterapii adjuwantowej oceniano w badaniach obrazowych oraz oceniając poziom markera Ca-125 we krwi po III i VI kursie chemioterapii lub wykonując operacje second look po III i VI kursie. Uzyskano lącznie 10 (59%) remisji calkowitych (CR), w tym 8 (47%) remisji potwierdzonych w badaniach histopatologicznych, dwie (12%) remisje calkowite kliniczne oraz 4 (29%) remisje cześciowe (PRO histopatologiczne. U 2 pacjentek (12%) doszlo do progresji choroby (PD). Łączny odsetek odpowiedzi wyniosl 88% (15 chorych). 7 calkowitych remisji (41%) uzyskano u pacjentek z chorobą resztkową Wnioski Uzyskane wyniki potwierdzają skutecznośc chemioterapii dozylnej skojarzonej z dootrzewnową. Skojarzenie tych dwoch metod terapii pozwala na zwiekszenie odsetka odpowiedzi. Problemem pozostaje jednak przedluzenie czasu trwania remisji.

The influence of selected suturing methods of the uterus horn on the reproductive ability of rat females, uterus wall morphology and endometrium surface was assessed. It was found out that the operative trauma involvement of the mucosa resulted in such regressive and degenerative changes as: changes in the muscularis continuity, diverticula of uterine cavity, fibrosis, endometrium atrophy and mucosa focal oedema of the "cystic micro-polyp" type. The morphological changes resulted in reproduction impairment in the animals where the surgical suture involved the mucosa of their uteri.

The purpose of the study was assessment of the clinical usefulness of the fetal acceleration test (FAT) for a preliminary evaluation of the state of the fetus in post-term pregnancy and the possibility of replacing the time-consuming and, sometimes, aggressive contraction stress test (CST) with FAT. The investigation was carried out on 151 pregnant outpatients subjected to 302 tests. In 118 cases the indication for tocographic monitoring was relative pregnancy prolongation. All patients had both tests done at the same time, FAT by the method of Lee and CST by the method of Ray. The tests were repeated at intervals of 5-7 days until labour. A high correlation was demonstrated between both tests (91%): and they were found to be highly useful for monitoring post-term pregnancy. FAT performed in outpatients makes it possible to avoid hospitalization without risk in many cases. A negative or doubtful result of FAT should be an indication to performing CST or for hospitalization. The results of the tests enable the condition of the fetus to be predicted for the following 5-7 days. They are, however, insufficient for drawing conclusions as to the course of labour and the state of the fetus at birth.

Bacteriologycal examinations of vaginal swabs from the cervix obtained during 45 amnioscopies, demonstrated a rise in culture positivity after the 2-nd and 3-rd amnioscopies. Bacteriologycal examinations in the same women on the 2-nd and 3-rd days of puerperium demonstrated a change of bacterial flora with appearance of more virulent flora. The problem of possible "ascending" infections or hospital infections is discussed.