Human endogenous retrovirus K (HERV-K) is distinctive among the retroviruses that comprise about 8% of the human genome in that multiple HERV-K proviruses encode full-length viral proteins, and many HERV-K proviruses formed during recent human evolution. HERV-K gag proteins are found in the cytoplasm of primary tumor cells of patients with seminoma. We identified HERV-K-specific T cells in patients with a past history of seminoma using the interferon-gamma ELISPOT assay and an MHC-HERV-K peptide-specific tetramer. A minority of apparently healthy subjects without evident germ cell tumors also made HERV-Kspecific T cell responses. In summary, we detected T cell reactivity to HERV-K peptides in both past seminoma patients and a minority of apparently healthy controls.

HomeRadiologyVol. 199, No. 1 PreviousNext ReviewsClinical OncologyAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Apr 1 1996https://doi.org/10.1148/radiology.199.1.142MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Apr 1996 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 199, No. 1 Metrics Altmetric Score PDF download

HomeRadiologyVol. 201, No. 3 PreviousNext ReviewsAtlas of Diagnostic Oncology. 2nd edAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Dec 1 1996https://doi.org/10.1148/radiology.201.3.792MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Dec 1996 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 201, No. 3 Metrics Altmetric Score PDF download

HomeRadiologyVol. 196, No. 1 PreviousNext ReviewsRadiation Oncology: Technology and BiologyAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Jul 1 1995https://doi.org/10.1148/radiology.196.1.174MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: July 1995 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 196, No. 1 Metrics Altmetric Score PDF download

HomeRadiologyVol. 197, No. 2 PreviousNext ReviewsThe Lymphatic System and Cancer. Frontiers of Radiation Therapy and Oncology, vol 28Alan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Nov 1 1995https://doi.org/10.1148/radiology.197.2.344MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Nov 1995 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 197, No. 2 Metrics Altmetric Score PDF download

Six months ago, a 62-year-old white man had a diffuse T-cell lymphoma involving the skin of the right cheek which was successfully treated by radiations. He now presents with vertical diplopia and an inferior oblique extraocular muscle palsy. Magnetic resonance imaging (MRI) reveals abnormalities in both sides of the frontal falx and in the genu of corpus. Over the next month, he rapidly becomes confused, lethargic, and disoriented. Cerebrospinal fluid (CSF) examination is negative. Repeat MRI again shows three masses suggestive of metastases. He now has tumorous nodules on his scalp, forehead, and neck.

In recent years, the issue of gender bias in clinical decision making has attracted increasing attention. Evidence supporting possible discrimination on the basis of gender in the diagnosis or treatment of patients with cancer has been offered. We investigated possible gender bias in clinical decision making by analyzing the Patterns of Care Study data on palliative radiotherapy. Information on 784 patients treated in 1984–1985 for metastatic cancer causing bone pain, obstruction of a hollow viscus, or neurologic dysfunction was reviewed. There were 395 men and 389 women in the study population from 49 institutions around the country. The median dose of radiation delivered was 3,000 cGy. This was generally done in 6–10 treatments over 8–14 days. No significant difference was found between men and women in the total dose of radiation delivered or elapsed days of treatment. These data suggest that palliative radiation therapy is delivered without regard to the gender of the patient.

HomeRadiologyVol. 191, No. 2 PreviousNext ReviewsThe Basic Science of Oncology. 2nd edAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:May 1 1994https://doi.org/10.1148/radiology.191.2.370MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: May 1994 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 191, No. 2 Metrics Altmetric Score PDF download

HomeRadiologyVol. 191, No. 2 PreviousNext ReviewsCancer Medicine. 3rd ed, 2 volsAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:May 1 1994https://doi.org/10.1148/radiology.191.2.338MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: May 1994 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 191, No. 2 Metrics Altmetric Score PDF download

HomeRadiologyVol. 187, No. 2 PreviousNext ReviewsThe Children of Atomic Bomb SurvivorsAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:May 1 1993https://doi.org/10.1148/radiology.187.2.352MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: May 1993 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 187, No. 2 Metrics Altmetric Score PDF download

HomeRadiologyVol. 189, No. 3 PreviousNext ReviewsCancer of the OvaryAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Dec 1 1993https://doi.org/10.1148/radiology.189.3.720MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Dec 1993 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 189, No. 3 Metrics Altmetric Score PDF download

HomeRadiologyVol. 184, No. 3 PreviousNext ReviewsPrinciples and Practice of Radiation Oncology. 2nd edAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Sep 1 1992https://doi.org/10.1148/radiology.184.3.794-aMoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Sept 1992 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 184, No. 3 Metrics Altmetric Score PDF download

The optimal treatment of prostatic carcinoma limited to the gland remains controversial. Treatment has included implantation of Iodine-125 seeds via both a suprapubic approach and, more recently, a transperineal technique utilizing ultrasound guidance. We recently have noted a heretofore unreported complication with this latter technique, namely, embolization of seeds to the lungs. Review of the chest x-ray films of 31 patients who underwent suprapubic implants showed no evidence of this phenomenon. One of 5 patients undergoing transperineal implant was found to have seeds lodged in the lung. Complications surrounding the various treatments of localized prostate carcinoma are reviewed.

Quality assurance, an issue receiving great attention in medicine of late, has its origins in the consumerism of the mid 60's and in the budgetary problems which became more pronounced following the oil embargo of the 1970's. Consumerism, initially concerned with product safety, eventually extended to the patient/doctor relationship. Physicians became providers of healthcare, and as such were increasingly viewed as liable for the results of that care. A bad result implied bad care. The rate of malpractice claims began to increase, with a concomitant increase in malpractice insurance premiums. This upward pressure on medical costs came at a time of economic crisis, related in part to increasing oil costs, competition from foreign manufacturers, and rising national debt. It was inevitable, therefore, that those who pay for medical care (private insurers and the government) would look for ways to ensure that the care they were buying was both necessary and of good quality.

HomeRadiologyVol. 174, No. 2 PreviousNext ReviewsRadiation Therapy and YouSally Hall, Caren Westrich, Alan D. SteinfeldSally Hall, Caren Westrich, Alan D. SteinfeldSally HallCaren WestrichAlan D. SteinfeldPublished Online:Feb 1 1990https://doi.org/10.1148/radiology.174.2.472MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Feb 1990 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 174, No. 2 Metrics Altmetric Score PDF download

HomeRadiologyVol. 177, No. 3 PreviousNext ReviewsRadiation Therapy of Benign DiseasesAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Dec 1 1990https://doi.org/10.1148/radiology.177.3.694MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Dec 1990 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 177, No. 3 Metrics Altmetric Score PDF download

HomeRadiologyVol. 172, No. 3 PreviousNext ReviewsRadiation Oncology: Rationale, Technique, Results. 5th edAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Sep 1 1989https://doi.org/10.1148/radiology.172.3.660MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Sept 1989 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 172, No. 3 Metrics Altmetric Score PDF download

HomeRadiologyVol. 172, No. 2 PreviousNext ReviewsPractical Gynecologic OncologyAlan D. SteinfeldAlan D. SteinfeldAlan D. SteinfeldPublished Online:Aug 1 1989https://doi.org/10.1148/radiology.172.2.402MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: Aug 1989 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 172, No. 2 Metrics Altmetric Score PDF download