Journal Article Verrucous epidermal naevus and naevus spilus associated with lower limb asymmetry and right bundle‐branch block: a case of phacomatosis pigmentokeratotica? Get access A. Baroni, A. Baroni Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Staibano, S. Staibano Biomophological and Functional Sciences, Section of Anatomical Pathology, University Federico II of Naples, Naples, Italy E‐mail: adone.baroni@gmail.com Search for other works by this author on: Oxford Academic Google Scholar T. Russo, T. Russo Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar V. Piccolo, V. Piccolo Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar R. A. Satriano, R. A. Satriano Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Vozza, A. Vozza Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Vozza G. Vozza Deparment of Dermatology and Venereology, Second University of Naples, Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 37, Issue 1, 1 January 2012, Pages 74–75, https://doi.org/10.1111/j.1365-2230.2011.04134.x Published: 01 January 2012

Kerion Celsi is a parasitic fungal skin infection that tends to occur mainly on the back of the neck, scalp or beard. It is caused by animal fungi. Sometimes the condition resolves itself in a matter of weeks but hair loss in the affected area may be permanent. We report a case of a young woman with Kerion Celsi favored by the use of a tretinoin+minoxidil+betametasone valerate lotion.

Leishmaniasis is a human disease produced by a parasite of the Leishmania genus transmitted by prick of an infected female sandfly. The disease occurs clinically with either cutaneous, mucocutaneous or visceral form, depending on the infective species and the immune status of the patient. Antimonial drugs are the current treatment of choice for all clinical forms. We report a case of cutaneous Leishmaniasis in a young girl successfully treated with itraconazole.

Kaposi's sarcoma (KS) of the tongue is extremely rare in immunocompetent patients. We report a case of KS of the tongue associated with a median rhomboid glossitis. The main clinical, pathological and immunohistochemical features allowed the differential diagnosis.

Background Cancer might be envisaged as the result of a genetic process causing the unregulated proliferation of a given cell as well as its inability to undergo differentiation and/or apoptosis. Alterations of genes regulating cell division cycle appear to play a key role in the development of human cancer.Objective On the bases of the above considerations, we decided to establish new cell lines from human melanoma specimens, in order to analyse the molecular alterations in primary preparations of malignant cells.Results The present paper describes two new established cell lines and their genetic and biochemical features. Both the melanoma cell lines show inactivation of the cyclin-dependent kinase inhibitor gene, CDKN2A/p16(INK4A), thus demostrating that this alteration occurs in primary human melanomas. No other alterations were observable when we investigated several different cell cycle genes including those encoding cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors. Analyses at protein level by means of immunoblotting confirmed the results obtained at the genetic level. Moreover, the inducibility of a pivotal cyclin-dependent kinase inhibitor gene, namely p21(CIP1) gene, was obtained by treating the cells with histone deacetylase inhibitors, namely butyrate and phenylbutyrate.Conclusions Our results suggest a primary role of cyclin-dependent kinase inhibitor genes inactivation in the origin of human melanoma and allow the proposal of new therapeutic strategies based on the transcriptional activation of p21(CIP1) gene.

The authors report a case of congenital rubella in a 7-month-old female infant presenting a Blueberry Muffin Rash. Blueberry Muffin Syndrome is a cutaneous manifestation characterized by widespread maculo papular lesions of a reddish-blue or magenta colour, due to persistent dermal erythropoiesis in patients with congenital viral infections.

Background. Purpose of our study was to assess how much the presence of p53 mutation in lesions by Lichen Sclerosus (LS) and Lichen Simplex Chronicus (LSC) can influence the neoplastic evolution of these pathologies and, consequently, the therapeutic approach. Methods. At the Department of Obstetrics and Gynecology of the Second University of Naples (SUN) in collaboration with the Dermosyphilopathic Clinic of the SUN, during the period 1995-1999, we investigated p53 expression in 8 cases of histologically proven vulval LS and in 10 cases of vulval Lichen Simplex Chronicus (LSC) using p53 gene mutation analysis. Results. There was a significant increase in p53 immunoreactivity in vulval LS compared to vulval LSC. The patients suffering from LSC responded to simple dermatological methods, mainly topical corticosteroids and retinoids, together with LS patients negative at p53 gene mutation analysis (37.5%); while patients suffering from LS with p53 immunoreactivity (62.5%) were subjected to bilateral vulvectomy and lymphoadenectomy. The follow-up, performed so far in all the studied cases, in no case showed neoplastic evolution. Conclusions. The absence of p53 mutations in vulval lichen, with negative histological examination, allows local pharmacological treatment with good results. Contrarily, once p53 mutation is evidenced, in our opinion, demolition surgical treatment is essential because such condition can generate carcinogenetic mutations.

Journal of the European Academy of Dermatology and VenereologyVolume 16, Issue 4 p. 425-426 Prurigo gestationis A Rampone, A Rampone Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this authorB Rampone, B Rampone Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Search for more papers by this authorS Tirabasso, Corresponding Author S Tirabasso Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Corresponding author, via Gemito n° 5, 81031 Aversa (Caserta), Italy, tel. 0039 081 8111411, mob., 349 407 9302===Search for more papers by this authorI Capuano, Corresponding Author I Capuano Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Corresponding author, via Gemito n° 5, 81031 Aversa (Caserta), Italy, tel. 0039 081 8111411, mob., 349 407 9302===Search for more papers by this authorG Vozza, G Vozza Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this author A Vozza, A Vozza Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this authorN Rampone, N Rampone Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Search for more papers by this author A Rampone, A Rampone Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this authorB Rampone, B Rampone Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Search for more papers by this authorS Tirabasso, Corresponding Author S Tirabasso Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Corresponding author, via Gemito n° 5, 81031 Aversa (Caserta), Italy, tel. 0039 081 8111411, mob., 349 407 9302===Search for more papers by this authorI Capuano, Corresponding Author I Capuano Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Corresponding author, via Gemito n° 5, 81031 Aversa (Caserta), Italy, tel. 0039 081 8111411, mob., 349 407 9302===Search for more papers by this authorG Vozza, G Vozza Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this author A Vozza, A Vozza Operative Unity of Dermatology, Second University of Naples, Naples, Italy.Search for more papers by this authorN Rampone, N Rampone Institute of Obstetrics and Gynaecology, Second University of Naples, Naples, Italy,Search for more papers by this author First published: 28 August 2002 https://doi.org/10.1046/j.1468-3083.2002.00570_11.xCitations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Esteve E. Expectant management of pruritus in pregnant women. Ann Dermatol Venereol 1999; 126: 634–638. 2 The Drugs and Pregnancy Study Group. Strategy of treatment of pruritus during pregnancy. Ann Pharmacother 1994; 28: 17–20. 3 Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage 2001; 21: 151–168. 4 Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34–47. 5 St-Pierre MV, Kullak-Ublick GA, Hagenbuch B, Meier PJ. Transport of bile acids in hepatic and non-hepatic tissues. J Exp Biol 2001; 204: 1673–1686. Citing Literature Volume16, Issue4July 2002Pages 425-426 ReferencesRelatedInformation

Anthrax is a well known infectious disease affecting mainly animals and secondarily humans. Nowadays, human infection is very rare, although sporadic cases are reported in farmers and other workers who carry on anthrax-risk activities such as tanners, wool-carders, shearers. However, the disease is still endemic in several areas, especially in developing countries. Recently, bioterroristic attacks using anthrax spores were responsible for a renewed interest of the international medical community on this treacherous and extremely dangerous biologic weapon.

Background. To study the effectiveness and safety of spironolactone in association with the use of hydrogen peroxide as skin detergent, in the topical treatment of acne in female adolescents. Methods. Forty-eight adolescent women (aged 13 to 17) suffering from acne vulgaris were studied in a period of 24 months (October 1999-September 2001). They were all enrolled in the first month of study. They were topically treated with spironolactone (cream at 5%, twice a day on the face at a total dose of 50 mg). The cleansing of the face was performed with hydrogen peroxide stabilized on 12 volumes. Results. After 4 months of treatment, 83.3% of the adolescents completely recovered from the dermatosis. In the remaining 16.7%, satisfactory but no definitive outcomes were obtained after about 7 months of therapy. Any local or general side effect was reported, and neither alterations of the hematochemical parameters occurred. The favourable effects of the therapy, in 75% of the cases, persisted up to the sixth month from the suspension of the therapy; in the remaining cases the onset of relapses was quickly avoided by repeating the therapy. Conclusions. The application of spironolactone associated with the use of hydrogen peroxide as skin detergent, showed particularly effective and devoid of side effects in the treatment of common acne.

Background. To evaluate the evolution of pregnancy in women suffering from Systemic Lupus Erythematosus (SLE). Methods. Thirty pregnant women, with a clinical diagnosis of SLE in phase of remission, were examined between January 1998 and December 1999 at the Institute of Obstetrics and Gynecology of the Second University of Naples (SUN) in collaboration with the Institute of Dermosyphilopathy of the SUN. Mean patient's age was 31.5 years (range 28-35). All the women examined were multiparous and were followed from the beginning of pregnancy up to delivery. The treatment of the illness in pregnancy was carried out by parenteral administration of glucocorticoids (betamethasone 1.5 mg/day for 10 days every month) in the all the cases. Results. Such therapy did not influence the evolution of the pregnancy, the duration of labour, delivery and post-labour. In 90% of the cases the patients spontaneously gave birth during the 37 t h and 40 t h week. Conclusions. The effects of SLE on pregnancy are therefore negative on its evolution since this illness causes a necrotizing vasculitis of the placental vessels, responsible for the functional insufficiency of this organ. In women suffering from SLE, in phase of remission and without serious lesions on the single organs or apparatuses, the pregnancy can evolve up to term with remarkable benefit from the administration of glucocorticoids that are well tolerated both by the mother and fetus.

BACKGROUND:This study was performed to evaluate, in women suffering from Systemic Lupus Erythematosus (SLE), the relationship between the assumption of oral contraceptives and the evolution of the disease.METHODS:In the Institute of Obstetrics and Gynaecology in collaboration with the Institute of Dermosyphilopathical Clinic of Second University of Studies of Naples, 20 women in fertile age suffering from SLE with specific cutaneous manifestations were studied for the year 1999. All the patients requested to take, at contraceptive purpose, low-dosage estroprogestagens. The contraceptives we prescribed have, as active substance, the gestodene at the dose of 0.075 mg and the etinilestrdiol at the dose of 0.02 mg per day. Patients' group in object was compared for a year with a similar control group of women suffering from SLE not subjected to any pharmacological therapy.RESULTS:Only 5 patients out 20 have had to suspend therapy after 4 or 5 months, because a relapse of the illness was experienced while the others 15 patients did not lament a relapse of the illness. In the control group a more or less similar percentage of patients, during the months of the observation, spontaneously had episodes of relapse of the illness.CONCLUSIONS:The results of our brief study have shown that the administration of hormonal contraceptives in reality doesn't constantly produce immediate and remarkable exacerbations of the illness in women suffering from SLE. In our opinion the contraception with the latest estroprogestagens can comfortably be effected under strict medical control, probably because the medicines at low dosage are quickly metabolized and in the majority of the cases they don't have capacity to influence the course of such chronic connectivitis.

Dermatofibrosarcoma is a rare, low‐grade malignant skin tumour that can be considered the equivalent of malignant non‐cutaneous soft tissue fibrohistiocytoma. The high rate of recurrence of this tumour is correlated with poor surgical management because lesions, often smaller than 2 cm in diameter, may be confused with dermatofibroma or keloid.

Journal of the European Academy of Dermatology and VenereologyVolume 15, Issue 4 p. 375-376 Tinea capitis in two young women: possible favouring role of hair styling products A Vozza, A Vozza Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorE Fiorentini, E Fiorentini Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorF Tripodi Cutrì, F Tripodi Cutrì Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorF Di Girolamo, Corresponding Author F Di Girolamo Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Corresponding author, tel. +39 081 5666828; fax +39 081 5468759; E-mail: sensiven@inwind.it===Search for more papers by this authorRA Satriano, RA Satriano Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this author A Vozza, A Vozza Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorE Fiorentini, E Fiorentini Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorF Tripodi Cutrì, F Tripodi Cutrì Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this authorF Di Girolamo, Corresponding Author F Di Girolamo Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Corresponding author, tel. +39 081 5666828; fax +39 081 5468759; E-mail: sensiven@inwind.it===Search for more papers by this authorRA Satriano, RA Satriano Second University of Naples, School of Medicine and Surgery, Department of Dermatology, Via S. Pansini, 5–80131 Naples, Italy.Search for more papers by this author First published: 15 August 2008 https://doi.org/10.1046/j.0926-9959.2001.00300-15.xCitations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume15, Issue4July 2001Pages 375-376 RelatedInformation

We studied the clinical and bacteriological efficacy and the safety of ceftazidime in elderly patients suffering from recurrent chronic bronchitis. 33 hospitalized subjects (10 F. 23 M: mean age 78.5 +/- 6 yrs) were treated with ceftazidime (1 g b.i.d.) for a mean of 9 +/- 1.5 days. At the end of treatment all patients had positive clinical results, with bacteriological eradication equal to 95%. Only one case of relapse was observed at the follow up assessment. As to safety only one case of vomiting was observed (but did not require treatment withdrawal).

An open multicentre trial to study the efficacy and safety of ceftazidime in elderly patients has been conducted in four geriatric units on 135 subjects suffering from urinary-tract or respiratory-tract infections. Sixty-two patients were cured (45.9%), and 60 improved (44.4%). Of the evaluable cases bacteriological eradication was achieved in 91.3%. No adverse events were recorded.