Objectives: For patients with diabetes and cancer at the end-of-life and their families, the safety sought in end-of-life care leads them to opt for home care. In developing countries where palliative care is not yet effectively integrated into public health policies, factors such as long distances to hospital referrals, lack of adequate infrastructure and shortage of specialised health professionals create a sense of insecurity for people seeking end-of-life care. The present study explored the factors that reinforce the feeling of security and insecurity of family members who have opted to accompany their relatives with diabetes and/or advanced cancer at the end-of-life at home in Togo. Materials and Methods: This was an ethnographic approach based on observations and in-depth semi-structured interviews with people with the following characteristics: family members (bereaved or not) with experience of caring for a patient with diabetes and cancer at home at the end-of-life. The data were analysed using content and thematic analysis. This was done to identify categories and subcategories using the qualitative analysis software Nvivo12. Results: The results show that of the ten relatives interviewed, eight had lived with the patient. Factors contributing to the feeling of security in the accompaniment of end-of-life care at home by the family members were, among others: ‘Informal support from health-care professionals,’ ‘social support’ from relatives and finally, attitudes and predispositions of the family members (presence and availability to the patient, predisposition to respect the patient’s wishes at the place of end-of-life care and predisposition to talk about death with the dying person). Conclusion: The ‘informal support of health-care professionals’, the ‘perception of the home as a safe space for end-of-life care’ and the ‘social support’ of family members contributed most to the feeling of safety among family members accompanying their diabetic and cancer patient family members at the end-of-life at home in Togo. Therefore, palliative and end-of-life care must be rethought in public health policies in Togo to orientate this care toward the home while providing families/caregivers with the knowledge and tools necessary to strengthen care.

Background: The use of psychoactive substances among adolescents and young people in schools in Benin is growing despite its consequences on their health. This article analysed this practice, identified the types of use and their determinants along the consumption trajectory.Methods: It was mixed, transversal study and involved 617 students from high schools and colleges in Cotonou and Parakou in 2020. Sampling was in two-degree clusters. 65 students were drawn by reasoned choice and snowball for qualitative interviews. Data processing was done with SPSS software and content analysis.Results: The results show that there was a diversity of substances available, accessible and used by targets in the last three months prior to the survey. Three types of use were identified: experimental use, determined by curiosity (48.14%), the quest for generational identity (25.45%) and sociability (34.20%); misuse, influenced by the quest for physical and sexual performance (17.83%), intellectual performance (28.85%) and peer pressure (22.04%) and dependent use, determined by the precocity of experimentation (69.04%), family type (33.60%) and the relaxation of societal values.Conclusions: Adolescents living in abusive and dependent uses are particularly vulnerable in terms of health and social. This requires a preventive approach based on education in societal values, the fight against the availability of these substances and the early management of cases of dependence.

The use of tramadol by adolescents and young adults in schools is a public health issue. The objectives of this study was to identify students who use tramadol and to investigate the cytochrome CYP2D6 profiles of students at to investigate the potential risks that could be yielded from the usage of tramadol. To achieve this, 453 students participated in the study; R diversity 3.6.1 software in the RStudio environment was used to identify students experimenting with tramadol by calculating a score according to the ASSIST V3.0 tool. The CYP2D6 duplication allele and deletion allele were tested by PCR on DNA extracts from peripheral blood collected from these individuals. Sixty-seven students were found to be using tramadol and of these, 25 students or 37.31% required brief intervention for medical care. Similarly 85.43% of the subjects expressed the CYP2D6 gene. Of these, 7.28% had the duplication allele (CYP2D6dup) and 1.32% the deleted allele (CYP2D6*5). In addition, all subjects at moderate risk due to tramadol use expressed the CYP2D6 gene; the duplication allele (CYP2D6dup) was found in both types of subjects in the proportions of 4% (at risk) and 7.47% (not at risk) respectively. The genetic polymorphism of cytochromes P450 2D6 does not influence tramadol usage by these subjects.

Background Behavioural and structural factors related to sex work, place female sex workers (FSWs) at high risk of maternal mortality and morbidity (MMM), with a large portion due to unintended pregnancies and abortions. In the African context where MMM is the highest in the world, understanding the frequency and determinants of pregnancy and abortion among FSWs is important in order to meet their sexual and reproductive health needs. Methods Data from two Beninese cross-sectional surveys among FSWs aged 18+ (2013, N = 450; 2016, N = 504) were merged. We first performed exploratory univariate analyses to identify factors associated with pregnancy and abortion ( p < 0.20) using Generalized Estimating Equations with Poisson regression and robust variance. Multivariate analyses first included all variables identified in the univariate models and backward selection ( p ≤ 0.05) was used to generate the final models. Results Median age was 39 years ( N = 866). The proportion of FSWs reporting at least one pregnancy during sex work practice was 16.4%, of whom 42.3% had more than one. Most pregnancies ended with an abortion (67.6%). In multivariate analyses, younger age, longer duration in sex work, previous HIV testing, having a boyfriend and not using condoms with him were significantly ( p < 0.05) associated with more pregnancies. Conclusion One FSW out of five had at least one pregnancy during her sex work practice. Most of those pregnancies, regardless of their origin, ended with an abortion. Improving access to various forms of contraception and safe abortion is the key to reducing unintended pregnancies and consequently, MMM among FSWs in Benin.

The objective of this paper is to expose those socio-structural contexts revealing the social injustice and human rights violations that sub-Saharan women face every day when forced into sex work by unemployment or sickness. Results of a qualitative study highlighting some key structural determinants of sex work and HIV infection among FSWs will be presented and examined through the lens of the WHO conceptual framework for action on the social determinants of health. The results showed that most FSWs had lacked the necessary financial support at some point in their lives. Also, both the socioeconomic and political context failed to provide proper support to prevent involvement in sex work and the consequent risks of HIV. The cultural and societal values placed on the health and well-being of FSWs in Benin appear to depend on the degree to which sexual violence and adultery are perceived as a collective social concern. This portrait of FSWs calls for both long-term interventions through a structural determinant approach to HIV prevention, targeting all the women who could face such a financial situation well before their entry into sex work, while maintaining short and medium-term interventions on the intermediary determinants.

Background: Regular voluntary counseling and testing is a key component of the fight against HIV/AIDS. In Benin, the project SIDA-1/2/3 established to decrease HIV/sexually transmitted infection (STIs) among female sex workers (FSWs), implemented a multifaceted intervention, including outreach activities. The objective of this article was to present potential advantages and limitations of 3 categories of outreach interventions designed to increase the use of testing services among FSWs in Benin. Methods: This analysis is based on ethnographic fieldwork conducted in Benin from June to December 2012. Results: Sixty-six FSWs and 24 health care workers were interviewed. Their narratives revealed 3 main factors impeding the development of appropriate HIV testing behavior. These negative elements can be positioned along a continuum of health care behaviors, with each stage of this continuum presenting its own challenges: fear or lack of motivation to use testing services, inaccessibility of care when the decision to go has been made, and a perceived lack of quality in the care offered at the health care center. Many of these needs seem to be addressed in the outreach strategies tested. However, the study also exposed some potential barriers or limitations to the success of these strategies when applied in this specific context, due to social disruption, mobility, access to care, and hard to reach population. Conclusions: To increase the use of testing services, an outreach strategy based on community workers or peer educators, along with improved access to testing services, would be well adapted to this context and appreciated by both FSWs and health care workers.

Background: Regular voluntary counseling and testing is a key component of the fight against HIV/AIDS. In Benin, the project SIDA-1/2/3 established to decrease HIV/sexually transmitted infection (STIs) among female sex workers (FSWs), implemented a multifaceted intervention, including outreach activities. The objective of this article was to present potential advantages and limitations of 3 categories of outreach interventions designed to increase the use of testing services among FSWs in Benin.Methods: This analysis is based on ethnographic fieldwork conducted in Benin from June to December 2012.Results: Sixty-six FSWs and 24 health care workers were interviewed. Their narratives revealed 3 main factors impeding the development of appropriate HIV testing behavior. These negative elements can be positioned along a continuum of health care behaviors, with each stage of this continuum presenting its own challenges: fear or lack of motivation to use testing services, inaccessibility of care when the decision to go has been made, and a perceived lack of quality in the care offered at the health care center. Many of these needs seem to be addressed in the outreach strategies tested. However, the study also exposed some potential barriers or limitations to the success of these strategies when applied in this specific context, due to social disruption, mobility, access to care, and hard to reach population.Conclusions: To increase the use of testing services, an outreach strategy based on community workers or peer educators, along with improved access to testing services, would be well adapted to this context and appreciated by both FSWs and health care workers.

OBJECTIVE:To examine the relationship between violence, condom breakage, and HIV prevalence among female sex workers (FSWs).METHODS:Data were obtained from the 2012 cross-sectional integrated biological and behavioral survey conducted in Benin. Multivariable log-binomial regression was used to estimate the adjusted prevalence ratios of HIV infection and condom breakage in relation to violence toward FSWs. A score was created to examine the relationship between the number of violence types reported and HIV infection.RESULTS:Among the 981 women who provided a blood sample, HIV prevalence was 20.4%. During the last month, 17.2%, 13.5%, and 33.5% of them had experienced physical, sexual, and psychological violence, respectively. In addition, 15.9% reported at least 1 condom breakage during the previous week. There was a significant association between all types of violence and HIV prevalence. The adjusted prevalence ratios of HIV were 1.45 (95% confidence interval [95% CI], 1.05-2.00), 1.42 (95% CI, 1.02-1.98), and 1.41 (95% CI, 1.08-1.41) among those who had ever experienced physical, sexual, and psychological violence, respectively. HIV prevalence increased with the violence score (P = 0.002, test for trend), and physical and sexual violence were independently associated with condom breakage (P = 0.010 and P = 0.003, respectively).CONCLUSIONS:The results show that violence is associated with a higher HIV prevalence among FSWs and that condom breakage is a potential mediator for this association. Longitudinal studies designed to analyze this relationship and specific interventions integrated to current HIV prevention strategies are needed to reduce the burden of violence among FSWs.