Four patients with primary sclerosing cholangitis (PSC) were examined with the hepatobiliary agent Tc-99m-labeled DISIDA (diisopropylphenylcarbamoyl iminodiacetic acid), and the results correlated with those of invasive cholangiography. Three of the four patients exhibited a typical pattern of multiple, persistent focal "hot spots" in the duct system, representing stasis within the segmental ductal dilatations (beading), also seen on cholangiography. Cholescintigraphy is superior to cholangiography in cases of suspected PSC where there is nonfilling of biliary radicals due to high-grade stenosis. The finding of delayed hepatic parenchymal clearance can allow estimation of the degree of obstruction of the various branches of the major bile ducts. Cholescintigraphy offers a noninvasive method of investigating patients with suspected sclerosing cholangitis, leading to earlier diagnosis. Confirmation with invasive cholangiographic procedures is recommended.

Two patients with breast abnormalities, one malignant and one benign, were studied with nuclear magnetic resonance (NMR) imaging utilizing a cryogenic superconducting magnet. Three-dimensional NMR images were obtained in one case and single slice planar images were obtained in the other. The NMR images correlated well with the corresponding mammograms. Although both conditions exhibited a different signal intensity for the area of abnormality compared to adjacent ductal and fatty tissue, the configuration of the abnormal areas allowed distinction between benign and malignant process.

Computed tomographic (CT) findings in six cases of primary sclerosing cholangitis (PSC) are described. Computed tomographic findings correlate with cholangiographic findings and show ductal dilatations and distortions in the porta hepatis and in the liver parenchyma. The CT features are round, oval, or irregular, sometimes branching, focal dilatations of the biliary tree. When subtle, irregular dilatations of the intrahepatic biliary tree are observed, the presumptive diagnosis of sclerosing cholangitis can be made from CT. Confirmation of this diagnosis with cholangiography is essential in all patients. Recognition of this entity by a noninvasive method will avoid long delays in diagnosis and will expedite the use of the more definitive procedures such as endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography, or liver biopsy.

In order to determine the clinical usefulness of nuclear magnetic resonance (NMR) imaging, the investigators examined a variety of normal volunteers, patients with neoplastic lesions, and experimental animals. Preliminary results were obtained with the use of potential contrast agents. It was found that imaging applications of NMR in the vascular system, spine, brain, lung, and mediastinum offer certain advantages over other modalities. The absence of biological hazard as well as the ability to obtain unenhanced, noninvasive, gated images of the vascular system, as demonstrated in this study, make NMR particularly attractive. In addition to single-section capability, NMR makes it possible to obtain volume images of the spine and other organs which can be displayed in any desired plane or section thickness.

HomeRadiologyVol. 143, No. 2 PreviousNext Basal indentation of sessile polypoid lesions: a function of geometry rather than a sign of malignancy.A E Ament, R J Alfidi, P S RaoA E Ament, R J Alfidi, P S RaoA E AmentR J AlfidiP S RaoPublished Online:May 1 1982https://doi.org/10.1148/radiology.143.2.7071336MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In Article HistoryPublished in print: 1982 FiguresReferencesRelatedDetailsCited ByDiagnosis of early colorectal cancer invasion depth by quantitative evaluation of the basal indentation in CT colonographyMitsutoshiMiyasaka, DaisukeTsurumaru, YusukeNishimuta, YoshikiAsayama, SatoshiKawanami, EijiOki, MinakoHirahashi, HiroshiHonda2016 | Japanese Journal of Radiology, Vol. 34, No. 12The Teaching Files: GastrointestinalStephen E.Rubesin2010Computed tomographic air-contrast enema imaging for presurgical examination of colon tumors: assessment with colon phantoms and in patientsYasuyoKayashima, FumikoKimura, KaijiInoue, YukikoHonda, TadashiNakanishi, KatsuhideIto2008 | Radiation Medicine, Vol. 26, No. 1COLORECTAL CANCERClaireSmith1997 | Radiologic Clinics of North America, Vol. 35, No. 2Double Contrast Examination of the ColonAlainWeissman, JacquesGrellet, MichelClot1985Double Contrast Examination of the ColonAlainWeissman, JacquesGrellet, MichelClot1985Recommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 143, No. 2 Metrics Altmetric Score PDF download

Sessile polyps: analysis of radiographic projections with the aid of a double-contrast phantomAE Ament and RJ AlfidiAudio Available | Share