The importance of food security cannot be emphasized enough, as food is one of the necessities for human survival. The future of human race will depend upon its ability to meet food security and nutritional security of burgeoning population through crop improvement. The advancement of omics-based technologies such as genomics, transcriptomics, proteomics, metabolomics, and phenomics has been applied for crop improvement. These omics-based technologies help to improve crop yield, improve nutritional content, solve problems of food insecurity, and improve global hunger index. Moreover, integrating these multiomics approaches is now an effective approach to understanding gene expression network and other important plant traits that help improve crop productivity. Therefore, this chapter, provides a comprehensive overview of multiple omics technologies, network, and systems biology approaches with a special focus on crop improvement. This chapter also focused on advances in sequencing technologies and how omics technologies coupled with artificial intelligence, play a role in combating food insecurity. Challenges, problems, and complexities associated with these approaches in crop improvement have also been discussed here.