The expression of immunosuppressive molecules influences in the prognosis, metastasis appearance and cytostatic treatment response. Among these molecules, HLA-G and indoleamine 2,3-dioxygenase (IDO) are sobreexpressed in cancer, such as in gastrointestinal tumours, and they could contribute to its development. Their expression by tumor cells or by immune system cells facilitates that tumour cells scape from immune attack and could induce immunotolerance in other body sites, and also influence in treatment effectiveness. The knowledge of tolerogenic capacity of tumours helps not only in the understanding of cancer growth but also in developing new therapeutic approaches.

The expression of immunosuppressive molecules influences in the prognosis, metastasis appearance and cytostatic treatment response. Among these molecules, HLA-G and indoleamine 2,3-dioxygenase (IDO) are sobreexpressed in cancer, such as in gastrointestinal tumours, and they could contribute to its development. Their expression by tumor cells or by immune system cells facilitates that tumour cells scape from immune attack and could induce immunotolerance in other body sites, and also influence in treatment effectiveness. The knowledge of tolerogenic capacity of tumours helps not only in the understanding of cancer growth but also in developing new therapeutic approaches.