Objectives: To study the hormonal profile of patients of gynecomastia, preoperative evaluation management, and outcome. Materials and methods:Retrospective study of all male patients presenting to the outpatient in plastic surgery clinic with gynecomastia.Complete endocrinology workup was done for each patient.Patient were treated by either liposuction alone or combined with gland excision with modified intra-areolar incision.Patients were followed up at 2-week, 1-month, and 6-month interval for complications, recurrence, and esthetic outcome.Results: Overall complication and recurrence rate was low with early and long-term use of postoperative pressure garment.Modified intraareolar incision showed better esthetic outcomes in patients who underwent gland excision.Conclusion: Gynecomastia patient shows least recurrence and complications when treated with combination of liposuction and gland excision with superior esthetic results with intra-areolar incision.

Introduction: Longstanding contractures of the hand especially the digit significantly impair the function of the hand due to contracture of all the anatomical structures, including the skin, subcutaneous tissues, tendon sheath, tendons, and ligaments. The common mode of treatment like incision release and split skin graft (SSG) is not possible in long-standing contractures due to the risk of exposure to the tendon, neurovascular compromise of digits, and re-contracture. To avoid these risks and to correct the flexion contracture to get an extension of the digit without the requirement of the flap in long-standing postburn contractures of digits, we do the surgical release of skin and subcutaneous tissue and distraction histogenesis of the short or contracted tendons, ligaments, and neurovascular bundle. Materials and Methods: From June 2017 to June 2022, a prospective study was carried out at a single institute. Patients of all age groups and gender presented with long-standing (≥3 years old) severe postburn contracture. Single or two digits were included in the study. 16 digits in 15 patients with long-standing contractures were operated on by the surgical release of skin and subcutaneous tissue. The resultant skin defect was covered with either a split-thickness skin graft or multiple Z plasty as the broad scar or band-like scar was present respectively in the surrounding area. Contracture of the neurovascular bundle and tendons ligament and capsule was dealt with distraction histogenesis with the application of a distractor simultaneously. Results were assessed – improvement of range of motion (ROM) as excellent, good satisfactory at proximal interphalangeal (PIP) joint (90–110), (60–89), (<59) at distal interphalangeal (DIP) joint (51–60), (41–50), (<40) metatarsophalangeal (51–60) (41–50) (<40) and improvement of flexion contracture. Results: The mode of burn injury was thermal burn in 53.3%, electric burn in 40%, and scald burn in 6.66% of patients. The mean duration of contracture of patients was 5 years and 2 months. All the patients presented with flexion contracture but one with ulnar flexion contracture, one with radial flexion contracture, and one dorsiflexion on the medial side at the great toe. Only PIP joints were involved in 62.5%, while PIP + DIP joints in 12.5% and DIP joints in 18.7%. Index finger and little finger each were 31.12% of patients. Z-plasty was done in 37.3% of patients, and SSG was covered in 62.6% of patients after the surgical release of contracture. Average days of distraction were almost equal in both Z plasty and SSG cover patients. In 50% of patients with Z plasty distraction time was <15 days. Failure of operation was in one patient where flexion contracture of the little finger at the PIP joint was only improved up to 30° and the patient developed re-contracture. Complete extension of digits was achieved in 75% of patients. Conclusion: For long-standing digital contractures-surgical release with the distraction histogenesis technique seems to be a reasonable option to obtain a satisfactory extension of contracted digits, good ROM, lesser complications, short hospital stay, preventing the risk of neurovascular compromise to fingers, exposure of tendons and without the need for any flap cover.

Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results: High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was $216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with $195 for low FiO2 leading to a −$11 (95% CI: −$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was $1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this.

Objectives-Because of the variable amount of deficit of tissue in cleft ear lobule, Reconstruction of Congenital clefts of ear lobule is challenging so treatment of congenital clefts of ear lobule needs customization to deal with the deficient volume of tissue in three dimensions (thickness, length, and width). In this series, we describe the three-dimensional reconstruction of the congenital cleft of the ear lobule with lipo-dermal flap and the evaluation of clinical outcomes in terms of the aesthetic expectation of the patient. Materials and methods- Patients of all age groups and gender who presented with fresh congenital cleft of ear lobule underwent Three-dimensional reconstruction with lipo-dermal flap from 2017 to 2022 were included. We used customized repair for deficient tissue of the congenital cleft of the lobule by de-epithelizing skin of all cleft surfaces and raising lipo-dermal flap. Results- Out of (06) cases, one case was male and 5 cases were females, with an average age group of 20.16 years. 33.33% of the congenital cleft of lobule was presented with three lobes and 66.6% of cases presented with two lobes. The aesthetical appearance was assessed as per criteria and was found good in 83.3% and very good in 16.6% of cases. Conclusions- Three- dimensional reconstruction of the congenital cleft of the ear lobule with lipo-dermal flap is a simple and effective technique to correct lobule deformities in proportion to the extent of the cleft and yields an aesthetically good pleasing ear lobule which matches with opposite side ear without complications.

Background: Raw areas post injury and excision of scar or tumor are of primary concern for both patients and attending surgeons because of notable functional and cosmetic impairment. Although split-thickness skin grafting (SSG) is a simple and comparatively minimally invasive treatment option, wound breakdown usually occurs due to the fragility of the skin. The dermal regeneration templates (DRTs) along with thin SSG are well recognized in acute burn surgery where thicker durable coverage is required. The study aimed to determine the role of the DRT and thin SSG as a reconstruction option for scars and raw areas with or without exposed bone and tendons. Materials and Methods: This study was carried out between October 2020 and April 2023 in 8 patients and 11 sites. DRTs were applied on raw areas (after burns, trauma, excision of scar or tumor, etc.). The thin SSG cover is done either immediately (one stage) or within 3 weeks (two stages). The results are assessed based on matrix take, graft takes, suppleness of grafted skin, color match, donor site morbidity, and complications such as SSG loss, contracture, infection, hematomas, blisters, seromas, and silicone detachment. Results: Out of eight patients, four were female, with an age range from 9 months to 45 years. The children were 50% and <7 years of age. The distribution of cases was 50% of scar whereas 50% of raw areas after tumor excision and posttrauma. Out of 11 sites, 7 sites were of burn cases including 3 sites of postburn scar and 4 sites of postburn raw areas. The mean SSG take rate was 98.36%. The mean follow-up time was 8 months. We found that grafted skin was supple in 72.27% and slightly hyperpigmented from the surrounding area in 100% of cases. The average time of healing of the donor site was 6.9 days without any hypertrophy and pigmentation. Conclusion: The DRT and thin SSG appear as a new alternative for the reconstruction of scars or small raw areas with or without exposed bone or tendons. The advantages of this technique are because of immediate availability, simplicity, and reliability and meet esthetic value without any formation of keloids at the donor site.

Background Scalp arteriovenous malformations (AVMs), or cirsoid aneurysms of the scalp, usually present with troublesome symptoms and cosmetic disfigurement. Endovascular/percutaneous embolization has evolved as a sole treatment method or adjunct to surgical excision in the management of scalp AVMs with an excellent outcome. Purpose To discuss minimally invasive techniques for treating scalp AVMs as well as to highlight the role of embolization before surgery. Material and Methods This is a retrospective study of 50 patients with scalp AVM who underwent embolization (percutaneous/endovascular) during 2010-2019 at a tertiary care center. n-butyl cyanoacrylate (n-BCA) was used as an embolizing agent in all the cases and the patients were followed up at three- and six-month intervals with Doppler evaluation. Results A total of 50 patients were included in the study. The occipital region was the most common location; 82% were Schobinger class II lesions and 18% were class III lesions. Thirteen patients had small-sized AVMs and 37 patients had large-sized AVMs. Post-embolization surgery was performed in 36 patients. Of the patients, 28 underwent percutaneous embolization, 20 underwent endovascular embolization, and two underwent both to achieve complete embolization of the lesion. The number of percutaneous procedures increased in the latter half of the study period as the safety and efficacy of the technique were established. No major complications were seen in this study. Conclusion Embolization of scalp AVMs is a safe and effective technique and can be used in isolation for small lesions and as an adjunct procedure to surgery for large-sized lesions.

Objective: In the initial days of the coronavirus disease 2019 (COVID-19) pandemic, the Indian Council of Medical Research (ICMR) recommended the use of hydroxychloroquine (HCQ) as chemoprophylaxis for health-care workers (HCWs) involved in the care of COVID-19 patients. The present survey aimed to assess the knowledge and compliance of HCQ prophylaxis as per the ICMR recommendations among Indian HCWs during the first wave of the pandemic. Methods: A validated 19-item questionnaire-based survey was distributed to HCWs in our apex tertiary care institute who had completed their duties in the COVID-19 wards to assess the knowledge, attitude, and compliance of all sections of HCWs regarding the ICMR-recommended HCQ prophylaxis. Participation in the survey was voluntary, and anonymity was maintained. Data obtained from the responses were collated and analyzed. Findings: Two hundred and fourteen out of 250 HCWs completed the survey (85.6% response rate). Among 214 participants, 87.9% were below the age of 40 years. 83.2% were aware of the use of HCQ for possible prevention of COVID-19 infection, while only 24.6% took HCQ for 7 weeks as was recommended during that period. The main reasons given by 37.3% of the HCWs for not taking HCQ were their knowledge and research on HCQ, where side effects were prominent. Side effects were reported by 35% of the respondents, of which the most notable was nausea/vomiting (14%) followed by gastritis (12%). Conclusion: The poor compliance with HCQ prophylaxis by HCWs was influenced by their knowledge and research, lack of strong scientific evidence, and drug-associated adverse effects.

Introduction:The nationwide lockdown in India and diversion of healthcare resources toward COVID care have hampered the non-COVID care.In this study, we assessed the effect of the first 6 weeks of lockdown on non-COVID super-specialty surgical case management at a tertiary care center.Materials and methods: This was an observational study involving eight surgical specialties (cardiothoracic and vascular surgery (CVS), Endocrine Surgery, maternal and reproductive health [MRH], Neurosurgery, Pediatric Surgery, Plastic Surgery, Surgical Gastroenterology, and Urology).Information was gathered using two forms: (a) Patient-wise form for surgical procedure (preoperative preparation, anesthesia, and surgical details) (b) Department-wise summary of procedures for comparison with the last year's records.Results: During the study period, 112 cases were performed compared to 1,062 performed last year during the same time frame.CVS department experienced the greatest decline (98%) in cases.Except for COVID testing, no difference in practice was documented (preoperative investigation and anesthesia preference).However, majority of the procedures were performed by an open technique.The use of personal protective equipment (PPE) by anesthetists and surgeons was not widespread and uniform across various specialties; the level of comfort was low suggested by low acceptance.Duration of surgery as well as hospital stay did not increase due to the COVID pandemic. Conclusion:The nationwide lockdown resulted in a marked reduction in the number of non-COVID surgeries, much more than the diversion of the workforce toward COVID facilities.The number of procedures decreased to <20% than in the previous year.The use of PPE was not consistent during procedures on COVID-negative patients.

Background: A lot of options have been tried for bridging the two ends of the injured nerves. Researchers have used decellularized nerve grafts, artificial materials and even nerve growth factors to augment functional recovery. These materials are either costly or inaccessible in developing world. Objective: The study aimed to evaluate the efficacy of the silicone conduit in a rat sciatic nerve injury model. Materials and Methods: 24 healthy Sprague-Dawley (SD) rats (250-300 grams; 8-10 weeks) were used and right sciatic nerve was exposed; transected and re-anastomosed by two different methods in 16 rats. In control group, n = 8 (Group I) the sciatic nerve was untouched; Group II (reverse nerve anastomosis, n = 8): 1-centimeter of nerve was cut and re-anastomosed by using 10-0 monofilament suture; Group III (silicone conduit, n = 8) 1-centimeter nerve segment was cut, replaced by silicone conduit and supplemented by fibrin glue]. Evaluation of nerve recovery was done functionally (pain threshold and sciatic functional index) over 3 months and histologically and electron microscopically. Results: Functional results showed a trend of clinical improvement in Group III and II but recovery was poor and never reached up to normal. Histopathological and electron microscopic results showed an incomplete axonal regeneration in Groups II and III. Psychological analyses showed that no outwards signs of stress were present and none of the rats showed paw biting and teeth chattering. Conclusion: The silicone conduit graft may be an economical and effective alternative to presently available interposition grafts, however for short segments only.

Introduction: Lymphangioma are rare vascular malformation that results from maldevelopment of primitive lymphatic sacs. They are most frequently found in the neck and axilla, while intra-abdominal and mediastinal lymphangiomas are uncommon. Atypical site of cystic hygroma in pediatric age group are usually difficult to diagnose clinically but can be diagnosed easily by ultrasound. The aim of the study was to evaluate the result of the intralesional bleomycin for macrocystic lymphatic malformation (LM) presenting at atypical site Material and Method: All patients of LM of other than head& neck, axilla and abdomen presenting in pediatric age group were included in the study. Mainstay of diagnosis was ultrasound and was supplemented by CT scan wherever required. All patients were managed with intralesional bleomycin (ILB) and surgical excision was done only if primary therapy failed. Result: Total 15 cases of LM presenting at atypical sites were included in the study. Series include two case of cystic hygroma of breast, 4 cases of cystic hygroma of anterior chest wall, two case of substernal LM, three cases of LM of parotid gland, one case of inguinal region cystic hygroma and 4 cases involving submandicular area. Complete resolution was observed in 13 out of 15 cases, and two cases had less than 50% reduction in size and were managed with surgical excision after second session of ILB. Conclusion: Aqueous Intralesional bleomycin is a cost effective alternative to surgery even at rare sites of LM which provide better aesthetic outcome, and avoids complication associated with surgery.

Background This study was performed to investigate the presence of SARS-CoV-2 virus in wounds of COVID-19 positive patients. Methods This is a single-center observational study. COVID-19 patients with wounds (traumatic/infective/surgical) were included in this study. Preoperative, intraoperative, or postoperative specimens were collected and analyzed with real-time reverse transcriptase polymerase chain reaction (rRT-PCR) to know the presence of the virus. Results A total of eight patients were included in this study. Eleven samples were collected (seven wound swabs, two peritoneal fluids, and two tissue specimens) and analyzed. None of the samples from the wound tested positive for the virus while they were tested positive for nasal swab taken simultaneously or within 3 days prior. Conclusion The wounds of COVID-19 patients are considered negative and can be managed with routine wound precautions.

Introduction: Cystic Lymphangioma (CL) commonly involves head and neck region and axilla. Involvement of other sites like salivary glands is very rare. This study was done to assess the role of bleomycin sclerotherapy in salivary gland CL with relevant review of literature. Aim: To assess the outcome of intralesional bleomycin as sclerotherapy in CL of major salivary glands. Materials and Methods: This was an observational study, done in Department of Paediatric surgery and Plastic surgery from July 2013 to July 2017. All diagnosed cases of pure CL involving major salivary glands were included, where as those with venous or arterial component were excluded from the study. Patients having previous surgery or other treatment modalities were also excluded. Primary mode of treatment of CL at present center was sclerotherapy using aqueous bleomycin. As per our protocol sclerotheray was done under sedation for paediatric patients using dopler ultrasound. Relevant demographic and clinical data of all 7 patients was collected in structured proforma and results were analysed. Results: Out of seven cases, four patient's lesion responded well in a single session, two patients reported unfavourable response even after second session hence, were managed surgically and one patient responded partially after first session and managed surgically later on. Conclusion: Cystic lymphangioma should be included in the differential diagnosis of cystic lesion of parotid and submandibular gland though its involvement is rare. Bleomycin sclerotherapy can be used as a safe and low cost treatment modality for the management of this rare entity.

INTRODUCTION:Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.METHODS:A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).RESULTS:Of 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.CONCLUSION:The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.

INTRODUCTION:Cystic lymphangioma (CL) is a multiloculated congenital malformation of the lymphatic system occurring in approximately 1 in 6,000-12,000 births, and it mostly presents at birth. The CL is of a variable size and it can be found at any age and in any part of the body. This study was carried out to observe the effect of intralesional aqueous bleomycin on giant CL presenting in adult and pediatric cases.MATERIALS AND METHODS:This is an observational study conducted in the department of pediatric surgery and plastic surgery from January 2012 to January 2020. All the diagnosed cases of lymphangioma measuring more than 5 cm in size and managed during this period were reviewed. The cases who had lesions with a vascular component or who had any history of previous surgery or any form of treatment were excluded from the study. A total of 19 cases were included in the study. The primary mode of management of CL at the present center is intralesional bleomycin sclerotherapy (IBS). This is the standard protocol followed at our center to treat the cases with CL. Relevant demographic and clinical data of all the included patients were collected on a structured proforma, and data were analyzed.RESULT:Four cases had a favorable outcome in a single session, seven cases showed a favorable response after the second session, and three cases showed a favorable response after the third session. Two cases showed a partial response even after the fourth session and were considered nonresponders, one of whom was operated on and the other who was satisfied with a partial response and was not willing to undergo surgical excision. No major complications were observed in the present series. A few cases developed mild pain with or without fever, but none of them required hospitalization.CONCLUSION:Intralesional bleomycin sclerotherapy (IBS) is a safe, effective, and economical treatment option for the management of large cystic lymphangiomas and it avoids surgery-related complications.Level of Study: IV evidence studyType of Study: Retrospective observational study.

Introduction: One of the most common burn sequels is postburn contracture (PBC) neck. These contractures affect the patient significantly causing both functional limitations and distorted aesthetic appearance. Therefore, the reconstruction of the head-and-neck area is a challenge for surgeons to restore not only the function but also to improve the esthetic appearance. Materials and Methods: We conducted a tertiary hospital-based prospective study in 12 patients with cases of severe PBC that underwent split-thickness skin graft (SSG) cover as a treatment modality and evaluated the results after the operative procedure in terms of function and appearance of the neck and its complications. Result of the function evaluated with respect to the range of extension movement of the neck –good 120°or more, fair 90°–120°, and bad <90°. Esthetic appearance evaluations were done on the patient's opinion with consideration of color match; maintenance of contour of the neck is good, fair, and not acceptable. Observation and Results: In our study, nine of cases were of thermal burn. All cases were presented with flexion contracture neck, while in seven cases were presented with 0° extensions of the neck. The neck contracture was released in two cases by excision of the scar and in rest of cases by incision methods. The defect was resurfaced with an unmeshed sheet of SSG in six cases, while in six of cases, the defect was resurfaced with a combination of an unmeshed and meshed sheet of SSG. Good functional recovery in terms of extension of the neck >120° in nine cases and fair esthetic appearance in eight cases and good in four cases. Conclusions: The excision of all scar tissue is possible only in few cases, but the incision releases were required in the majority of severe neck contractures. The STS grafting is a simple, reliable, and safe operation. Sheets of unmeshed SSG in the neck and lower face resulted in better postoperative neck function, the cosmetic appearance in terms of color match, and cervicomental angle.

BACKGROUND Scalp arteriovenous malformations (SAVMs) are seen in young individuals and skin involvement is common in large SAVMs. They are commonly seen in younger age group too. Pre-operative embolization followed by surgical excision and hair bearing scalp reconstruction with tissue expansion are the treatment of choice. Therefore, proper selection of tissue expander for reconstruction of hair bearing scalp, seems essential. This study evaluated excision of large SAVMs with aesthetic scalp reconstruction. METHODS We described management of 10 patients of large SAVMs with cutaneous involvement. All patients underwent pre-op embolization followed by surgical excision and hair bearing scalp reconstruction with tissue expansion. RESULTS All cases of large SAVMs healed well with minor complications. CONCLUSION While complete surgical excision with extirpation of the nidus is considered as the gold standard treatment, aesthetic hair bearing scalp restoration is also of paramount importance for the patient. This is done by using scalp tissue expansion after proper selection of the expander.

A 39-year-old male, live-related renal transplant recipient with stable graft function presented with multiple painless, non-itchy, papular lesions over the midback region. Three months later, these lesions became multiple abscesses with pus exudation (Figure 1). The patient had a history of injury to his midback from the sharp edge of cement stairs, which caused an abrasion. He had received a thymoglobulin induction and was on prednisolone, tacrolimus, and azathioprine. The microscopic examination of KOH mount of pus revealed multiple, septate, branching, brown-pigmented hyphae with thick-walled vesicular swellings (Supplementary Figure S1) suggestive of phaeohyphomycosis. The Gram’s stain also showed pus cells with moniliform septate as well as branching fungal hyphae with brown pigmentation seen as a slight golden brown color. The culture grew black mycelial fungus (Supplementary Figure S2) after 10 days of incubation in Sabouraud dextrose agar. The patient received 200-mg tablets of itraconazole twice a day. Tacrolimus was substituted for cyclosporine because of very high trough levels of tacrolimus. The pustular swelling healed and turned into a scar 1 month later (Supplementary Figure S3). The patient underwent a wide excision of the lesions along with skin engraftment after 2 months of itraconazole. Skin engraftment took well, with an optimally healed scar (Figure 2) and no recurrence after 2 months of follow-up. Figure 2Healed lesions (post–wide excision and skin engraftment) in the form of a scar in the thoracic region. View Large Image Figure Viewer Download Hi-res image

Retroperitoneal teratomas are extremely rare in adults and are typically benign tumors. We describe a case of a 48-year-old lady who initially presented with abdominal discomfort 18 years ago and was found to have a large right-sided supra-renal mass suspected to be an adrenal lesion. Following initial biochemical and imaging studies a diagnosis of non-functioning adrenal adenoma was made and she was managed conservatively. After being lost to follow up and remaining clinically well for many years, she once again presented with worsening abdominal pain. A right adrenalectomy was performed and the histology surprisingly confirmed a mature cystic teratoma with malignant transformation into a moderately-differentiated intestinal-type adenocarcinoma as well as having a focus of carcinoid tumour. She was admitted shortly afterwards with widespread metastatic disease and sadly passed away before any treatment could be instituted. Only a handful of cases of primary retroperitoneal teratomas have described adenocarcinomatous transformation. A carcinoid tumour within a teratoma is even less common and typically does not manifest systemic features. This case underlines the broad differential diagnosis of an adrenal mass and highlights several unusual aspects of a teratoma. We present the current literature and discuss the appropriate investigations, management and challenges involved in such rare cases.