Background: Odontogenic keratocysts (OKCs) are clinically aggressive lesions with relatively high recurrence rates. Dysregulation of functional equilibrium in the RANK/RANKL/OPG system is responsible for osteolysis associated with the development of OKCs. Previously published findings imply that immunoexpression of these 3 proteins may correlate with bone resorption activity in OKCs. Objectives: The rationale behind this study was to assess the potential for receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) expression, as well as RANKL/OPG expression ratio, to serve as prognostic indicators for OKC recurrence. Material and methods: We investigated the immunoexpression patterns of RANK, RANKL and OPG, and their correlation with recurrence rates, in 41 patients with OKCs treated with enucleation. Results: We found no statistically significant differences between recurrent and non-recurrent cysts in terms of either: epithelial (p = 0.404) and stromal (p = 0.469) immunoreactivity of RANK; epithelial (p = 0.649) and stromal (p = 0.198) immunoreactivity of RANKL; or epithelial (p = 1) and stromal (p = 0.604) immunoreactivity of OPG. We also did not find significant differences in the distribution of cases with respect to ratios of RANKL/OPG immunostaining scores between recurrent and non-recurrent OKCs, both in the epithelium and in the connective tissue (p = 1 and p = 0.237, respectively). Conclusions: Our results suggest that immunoexpression levels of RANK, RANKL and OPG at the time of pathological diagnosis, as well as the RANKL/OPG ratio, are not useful as prognostic markers for OKC recurrence.

Objective: The study aimed to evaluate total antioxidant capacity as well as levels of various enzymatic and non-enzymatic antioxidants, and oxidative stress markers in saliva of patients with oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL).Material and methods: Twenty patients with OSCC, 20 patients with OL and 20 healthy subjects were enrolled into this prospective study. Total Antioxidant Capacity (TAC), activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) as well as levels of total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, uric acid (UA), 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were estimated in saliva using appropriate biochemical methods.Results: The activity of SOD was significantly higher in OSCC group in comparison with OL and control groups. The levels of GSH were markedly lower in OSCC and OL patients as compared to the control group. Likewise, we found that GSH/GSSG ratio was markedly lower in the OSCC and OL groups. Levels of some biomarkers were influenced by clinical staging of OSCC and OL as well as by sociodemographic factors.Conclusions: The results of this pilot study suggest that salivary activity of SOD is higher in OSCC patients, whereas levels of GSH and GSH/GSSG ratio are lower in saliva of patients with OSCC and OL. Clinical staging of OSCC and OL, as well as some sociodemographic factors may also influence salivary antioxidant status.

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Rudnik M, Kaczmarczyk T, Bednarczyk A, Loster B. Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case. Journal of Stomatology. 2018;71(3):288-301. doi:10.5114/jos.2018.80642. APA Rudnik, M., Kaczmarczyk, T., Bednarczyk, A., & Loster, B. (2018). Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case. Journal of Stomatology, 71(3), 288-301. https://doi.org/10.5114/jos.2018.80642 Chicago Rudnik, Magdalena, Tomasz Kaczmarczyk, Anna Bednarczyk, and Bartlomiej W. Loster. 2018. "Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case". Journal of Stomatology 71 (3): 288-301. doi:10.5114/jos.2018.80642. Harvard Rudnik, M., Kaczmarczyk, T., Bednarczyk, A., and Loster, B. (2018). Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case. Journal of Stomatology, 71(3), pp.288-301. https://doi.org/10.5114/jos.2018.80642 MLA Rudnik, Magdalena et al. "Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case." Journal of Stomatology, vol. 71, no. 3, 2018, pp. 288-301. doi:10.5114/jos.2018.80642. Vancouver Rudnik M, Kaczmarczyk T, Bednarczyk A, Loster B. Orthodontic and surgical treatment of a patient with an impacted upper central incisor with dilacerations – systematic review of the literature with presentation of a case. Journal of Stomatology. 2018;71(3):288-301. doi:10.5114/jos.2018.80642.

We report the history of a 59-year old patient with systemic AL amyloidosis of intraoral manifestation. The patient first presented with complaints about dysphagia and remarkable enlargement of the tongue with highly reduced mobility, as well as bilateral submucosal thickenings on the cheeks. Histopathological examination of the incisional biopsy of the buccal mucosa and underlying tissues revealed AL amyloidosis. The microscopic presentation was, however, unique, as the amyloid deposits were present intracellularly in the striated muscles. The subsequent bone marrow biopsy confirmed the diagnosis of primary amyloidosis/multiple myeloma associated amyloidosis.

Wstęp: Standardowe znieczulenie miejscowe nie gwarantuje całkowitego ustąpienia bólu podczas zabiegu endodontycznego usuwania miazgi w stanie nieodwracalnego zapalenia.Celem pracy było sprawdzenie, czy miejscowe znieczulenie za pomocą morfiny w dawce 1 mg dodanej do standardowego znieczulenia za pomocą artykainy w porównaniu z samą artykainą zmniejszy odczuwanie bólu w czasie 48 godz. po zabiegu endodontycznym.Materiały i metody: W podwójnie ślepej próbie klinicznej uczestniczyły 32 osoby, które miały nieodwracalne zapalenie miazgi pierwszego zęba trzonowego szczęki. Uczestnicy badania byli zrandomizowani do dwóch grup: grupy badawczej, która otrzymywała artykainę i morfinę (n = 9), oraz grupy kontrolnej, która otrzymywała tylko artykainę (n = 23). Nasilenie bólu badano za pomocą numerycznej skali oceny bólu oraz skali wzrokowo-analogowej przed zabiegiem oraz 1, 2, 6, 12, 24 i 48 godz. po zabiegu.Wyniki: Nie stwierdzono istotnych różnic nasilenia bólu między dwoma grupami w obu skalach oceny bólu we wszystkich kolejnych punktach oceny aż do 48 godz. po zabiegu. Stwierdzono jedynie nieistotne statystycznie mniejsze odczuwanie bólu po 12 godz. u chorych leczonych morfiną i artykainą (p = 0,08). Badanie było finansowane z grantu Uniwersytetu Jagiellońskiego (UJ) i miało zgodę Komisji Bioetycznej UJ nr: 2008/K/ZDS/000518.Wnioski: Dodanie morfiny do artykainy w celu mniejszego odczuwania bólu podczas endodontycznego usuwania miazgi w stanie nieodwracalnego zapalenia nie ma wpływu na odczuwanie bólu, choć większą skuteczność tego znieczulenia obserwowano wcześniej podczas zabiegów chirurgicznych w jamie ustnej. Wskazane są dalsze badania oceniające skuteczność opioidów w miejscowym znieczuleniu podczas zabiegów endodontycznych.

Introduction :  Standard local anaesthetics do not guarantee complete absence of pain during endodontic debridement of the inflamed pulp. We investigated whether the addition of 1 mg of morphine to local articaine anaesthesia as compared to articaine alone could reduce pain sensations during endodontic debridement and within 48 h after the procedure. Materials and methods :  Thirty-two patients with pain attributed to irreversible pulpitis of the first upper molar participated in this randomized, double-blind trial. Patients were randomly assigned either to the study group (patients receiving periapical injection of modified local anaesthetic solution with morphine, n = 9) or to the control group (patients receiving standard anaesthetic solution without morphine, n = 23). The pain intensity was assessed using the visual analogue scale and verbal score before and directly after endodontic debridement, as well as at 1, 2, 6, 12, 24 and 48 h after the procedure. Results :  Neither the visual analogue scale nor verbal score differed between both groups before or during the endodontic debridement, as well as during 48-hour follow-up. However, there was an insignificant tendency for greater pain relief in patients treated with articaine and morphine at 12 h after endodontic debridement (p = 0.08). The study was funded by a Jagiellonian University in Poland (JU) grant, and was registered with the JU Ethical Committee No. 2008/K/ZDS/000518. Conclusions :  The addition of morphine to local articaine anaesthesia does not influence pain intensity in patients undergoing endodontic debridement in contrast to the previously described pain-relief effect in patients after oral surgery. However, future studies are needed to evaluate the role of opioids in local anaesthesia in endodontic procedures.

Odontogenic keratocyst (OKC) presents considerable variation in aggressiveness and propensity for recurrence, yet hitherto, no explicit clinicopathological features have been determined to clearly demonstrate the potential for relapse. This retrospective study aims to investigate the prognostic relevance of various clinicopathological features as well as immunoexpression of COX-2, bcl-2, PCNA, and p53 in sporadic OKC.