An association has been reported between a dopamine D(2) receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, chi(2) = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61-15.12). The association was detected only in men. The results were supported by a meta-analysis of all published case-control studies comprising a total of 9,152 subjects (chi(2) = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16-1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia.
Lars Terenius合作论文数Center for Molecular Medicine, Karolinska Institutet;Department of Clinical Neuroscience, Karolinska Institutet3
Erik Gunnar Jönsson合作论文数Psychosis Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo;Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet;Stockholms Läns Sjukvårdsområde3
B Edman-Ahlbom合作论文数2Agartz Ingrid合作论文数2
Lars Farde合作论文数Department of Clinical Neuroscience, Karolinska Institutet2Birgit Ekholm合作论文数2Agneta Gunnar合作论文数2Gaku Okugawa合作论文数2Hakan Hall合作论文数2C Tamagaki合作论文数2S. Arnborg合作论文数1Håkan Nyman合作论文数1Fa Wiesel合作论文数1GC Sedvall合作论文数1Marten Vares合作论文数1G Edman合作论文数1Goran Sedvall合作论文数1
Nikolaos Venizelos合作论文数Department of Clinical Chemistry, Stockholm, Sweden1Ingrid Agartz合作论文数1
Lena Flyckt合作论文数1L. Bjerkenstedt合作论文数1Hans Bergman合作论文数1
Arnoldo Frigessi合作论文数Oslo Centre of Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo;INTEGREAT1B. Edman合作论文数1
