Comparative analysis of the clinical laboratory data from 419 children and 468 adults hospitalized during the pandemic of A (H1N1pdm 2009) and pre- and post-pandemic periods (2010-2013) showed that the clinical presentation of the pandemic influenza in patients of all ages is generally typical for influenza, and its character is determined by the degree of involvement of lungs in the process. Besides, the incidence of pneumonia in adults is statistically significantly higher than in children. During all compared periods hyperthermia (≥ 39 degrees C), hemorrhagic and dyspeptic syndrome were observed. Some differences in the main clinical manifestations of pneumonia in recovered patients and patients who died of the severe pandemic influenza were observed. The regularities of the cytokine reactions depending on the intensity of intoxication and occurrence of complications were determined in patients of all ages. Medical efficacy of inclusion of antiviral chemotherapeutic agents into complex influenza treatment was proved.

The goal of our study was to estimate the efficacy of antiviral drug Oseltamivir for influenza treatment. We assessed the effect of Oseltamivir on the immune status of the 75 patients. It was formed 2 groups of observations with confirmed diagnosis of influenza: 38 received therapy Oseltamivir and 37 people receiving pathogenetic treatment. Treatment Oseltamivir contributes to a significant reduction in the duration of the catarrhal and intoxication syndromes and prevents the development of complications and exacerbations of chronic disease in persons with modified backdrop premorbid, which indicates for its high antiviral activity. We can assume the effect of Oseltamivir for restore the disturbed balance of cytokines, on assessing the dynamics of IL-1β, IL-8, IFNα, IFNγ in the serum.

Comparative analysis of the clinical laboratory data from 419 children and 468 adults hospitalized during the pandemic of A (H1N1pdm 2009) and pre- and post-pandemic periods (2010-2013) showed that the clinical presentation of the pandemic influenza in patients of all ages is generally typical for influenza, and its character is determined by the degree of involvement of lungs in the process. Besides, the incidence of pneumonia in adults is statistically significantly higher than in children. During all compared periods hyperthermia (≥39°C), hemorrhagic and dyspeptic syndrome were observed. Some differences in the main clinical manifestations of pneumonia in recovered patients and patients who died of the severe pandemic influenza were observed. The regularities of the cytokine reactions depending on the intensity of intoxication and occurrence of complications were determined in patients of all ages. Medical efficacy of inclusion of antiviral chemotherapeutic agents into complex influenza treatment was proved.

The aim of the current study was the investigation of the clinical features of ornithosis and respiratory mycoplasma infection during autumn outbreak in 2012 in 58 patients admitted to the Institute of influenza department of adult respiratory viral infections based at St Petersburg Botkin Infectious Diseases Hospital. It has been shown that the concomitant ornithosis and respiratory mycoplasma infection were registered more often in the group of young patients and the finding was statistically significant. Pulmonary form of the infection was registered more often in patients with respiratory mycoplasmosis. It was found that in patients with mycoplasma infection catarrhal and constitutional symptoms were longer in duration than in ornithosis or in concomitant ornithosis and mycoplasmosis and the findings were statistically significant. Macrolide antibiotics can be considered as the first-line medications in treatment of respiratory mycoplasmosis and ornithosis. According to our data, these antibiotics were more effective in ornithosis.

The goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those patients who developed pneumonia during acute phase of influenza. We have revealed a correlation between the severity and duration of symptoms of both uncomplicated and pneumonia-conplicated flu, and serum concentrations of proinflammatory (TNFα, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-1rа, и IL-10), as well as with indexes of interferon profile (antiIFNα, IFNα и IFNγ) in the patients.

The aim of this investigation was to study effect of cytokines in complex therapy of flu and the sharp respiratory diseases complicated and uncomplicated. The use of Interferal was reduces duration of catarrhal syndrome, the use of Betaleukin reduces terms of the permission pneumonic infiltration in a lung. Drugs have an effect on the level of cytokines and interferon.

This investigation was aimed for studying efficacy of Betaleukin in combined therapy of influenza and flu-like respiratory diseases complicated by pneumonia, and development of inclusion criteria. Treatment with Betaleukin was significantly associated with shorter duration of catarrhal syndrome and decreased resolution terms of lung infiltrates. Usage of Betaleukin was shown to influence the levels of pro- and anti-inflammatory cytokines and interferons. Betaleukin is effective in patients under 50 years old, independent on initial volume of lung infiltrates. Full resolution of pneumonia treated with Betaleukin was observed in patients with initial IL-1β concentrations under 80 pg/ml, or 80-120 pg/ml, and IL-1rа concentrations of 500-1000 pg/ml in blood serum.

The aim of the current study was the investigation of the clinical features of ornithosis and respiratory mycoplasma infection during autumn outbreak in 2012 in 58 patients admitted to the Institute of influenza department of adult respiratory viral infections based at St Petersburg Botkin Infectious Diseases Hospital. It has been shown that the concomitant ornithosis and respiratory mycoplasma infection were registered more often in the group of young patients and the finding was statistically significant. Pulmonary form of the infection was registered more often in patients with respiratory mycoplasmosis. It was found that in patients with mycoplasma infection catarrhal and constitutional symptoms were longer in duration than in ornithosis or in concomitant ornithosis and mycoplasmosis and the findings were statistically significant. Macrolide antibiotics can be considered as the first-line medications in treatment of respiratory mycoplasmosis and ornithosis. According to our data, these antibiotics were more effective in ornithosis.

Abstract. The goal of study was to evaluate cytokines level in blood of 60 patients with uncomplicated influenza and its relations with severity of intoxication symptoms. High level of TNFα, IL-10, IL-1Rа and low level of IFNγ was measured in serum of patients with severe intoxication syndrome during acute phase of disease. The duration of intoxication syndrome of influenza had a direct correlation with the concentration of TNFα, IL-6, IL-8, IL-1Rа, IL-10 and the opposite of IL-1β.

The goal of our study was to estimate the efficacy of antiviral drug Oseltamivir for influenza treatment. We assessed the effect of Oseltamivir on the immune status of the 75 patients. It was formed 2 groups of observations with confirmed diagnosis of influenza: 38 received therapy Oseltamivir and 37 people receiving pathogenetic treatment. Treatment Oseltamivir contributes to a significant reduction in the duration of the catarrhal and intoxication syndromes and prevents the development of complications and exacerbations of chronic disease in persons with modified backdrop premorbid, which indicates for its high antiviral activity. We can assume the effect of Oseltamivir for restore the disturbed balance of cytokines, on assessing the dynamics of IL-1β, IL-8, IFNα, IFNγ in the serum.