Abstract. A new role of B-cells in pathogenesis of multiple sclerosis (MS), their relations with B-cells indevelopment of inflammation and probable mechanisms of advanced therapeutic intervention in order to reach B-cell depletion are subject to discussion in present article. Here we describe a clinical case of MS with a resistant clinical course, and results of anti B-cell treatment. To attain maximal clinical effect, a novel therapeutic regimen (a combination of rituximab and mitozantrone) was applied. Clinical, radiological and laboratory methods were used to substantiate the efficiency of treatment.
E E Zueva合作论文数2Lapin Sv合作论文数2I S Ziuzgin合作论文数2Areg A. Totolian合作论文数2Skoromets A A合作论文数2евгений петрович евдошенко合作论文数1array в афанасьев合作论文数1L. G. Zaslavskii合作论文数1array в борзова合作论文数1array а десятик合作论文数1array н хостелиди合作论文数1array в шадривова合作论文数1array с зюзгин合作论文数1array м чернопятова合作论文数1array г бойченко合作论文数1array м игнатьева合作论文数1array о попова合作论文数1array с зубаровская合作论文数1array л маслянский合作论文数1array н климко合作论文数1array г волкова合作论文数1
Evgeniy Evdoshenko合作论文数1
