Atopic dermatitis is a common chronic inflammatory disease in children. The disease onset and eruption progression most commonly occur at the age of less than 6 months and coincide with the timing of the first complementary foods. Complementary foods are given to infants with atopic dermatitis at the same tone as to healthy babies; however, there are significant differences in complementary feeding tactics. The paper discusses in detail principles for choosing the first complementary foods for infants with atopic dermatitis, rules for introducing of complementary foods, necessary patient preparation, and precautions. The given assumptions are strengthened by a clinical example.

Objective : The aim of our study was to compare the effectiveness and tolerability of desloratadine solution vs syrup formulation in children with atopic dermatitis. Methods : Children of the 1 st group received desloratadine solution and children of the 2 nd group received desloratadine syrup 1,25 mg o.d. in complex atopic dermatitis treatment including also topical therapy, diet and emollients, for 4 weeks. Results : 40 children 12 to 24 months of age with no more than 45 points on the SCORAD scale were included in open-label comparative randomized trial. Subjective atopic dermatitis symptoms, itch and sleep disturbance due to itching, most rapidly decreased after treatment beginning. At the end of the study, itch completely resolved in most patients. Other symptoms such as erythema, papules and skin edema, excoriations, crusts and exudation also decreased. The SCORAD index decreased from 35.9 to 3.45 points and from 34.9 to 3.45 points in the 1 st and the 2 nd treatment groups, respectively. Treatment tolerability was good in both groups. Conclusion : Desloratadine application in atopic dermatitis complex treatment is effective in children and gives possibility to reach a disease remission in most patients. We did not reveal significant differences in two desloratadine preparations’ (solution and syrup) effectiveness and tolerability.

The diagnosis of allergic disease related to the group of immediate hypersensitivity involves confirmation of IgE sensitization: positive skin tests with the suspected allergen and/or detection of allergen-specific IgE. Research over the past decades showed that IgE synthesis may occur exclusively in the tissues of the affected organ and derived allergen-specific antibodies may not enter the systemic circulation. In contrast to «atopy», this concept of local sensitization was termed «entopy». local production of IgE was detected in more then 47% of adults previously diagnosed as having non-allergic rhinitis. besides the nasal mucosa, local sensitization was found in lymphoid tissues of nasopharyngeal ring, bronchial mucosa in some patients with non-atopic asthma, esophageal mucosa in patients with eosinophilic esophagitis. The processes of local immune response is currently studied and probably one day the accumulated data will swing our understanding of atopic sensitization, that will be reflected in classification and therapeutic approaches.

Food allergies (fa), defined as an adverse immune response to food proteins, effect up to 3-5% of the popula- tion in westernized countries, and their prevalence appears to be rising. a variety of mechanisms underlie the allergic reactions, not all of them run through the IgE sensitisation. the absence of sIgE in peripheral circulation characterize a group of non-Ig-Emediated disorders, such as food protein-induced enterocolitis, enteropathy and prococolitis. In case of eosinophilic esophagitis, gastritis and enterocolitis IgE sensitization arises in nearly 50%, therefore these disorders are classified as mixed-type. In some cases of gastrointestinal fa local IgE production, when switching to IgE synthesis occurs only in one organ, have been proved. although systemic investigation of this phenomenon is still lacking. Immune inflammation coursed by food allergens can involve nearly all organs and systems. this review focuses on gastroenterological manifestations of food allergy, except of broad field of gluten intolerance that demands a separate thorough reviewing.