Aim. The study microecology of the large intestine of children with cirrhosis before transplantation of the share liver. Materials and methods. Studied the fl ora of the colon 157 children of 1 to 17 years admitted to hospital for liver transplantation fragment from a related donor. Identi fi cation was carried out using microbial panels BD Crystal and databases BBL Crystal MIND. Methicillin-resistant staphylococci were determined by their sensiti- vity to oxacillin and cefoxitin. Beta-lactamase activity was tested using discs with ceftazidime and ceftazidime/ clavulanic acid. Results. Microecological revealed deep irregularities in the large intestine transplantation in children up lobe of the liver on a spectrum and composition of the micro fl ora. Among the resident micro fl ora decreased levels of bi fi dobacteria, lactobacilli and coliform bacteria, especially in children under one year. A sig- ni fi cant portion of the children surveyed (over 60–70%) had an increase of frequency of fi nding stateally bacteria, especially Klebsiella and enterobacteria in third children – non-fermenting bacteria – Pseudomonas and Acine- tobacter spp . Revealed the spread of strains of gram-negative bacteria with extended-spectrum betalaktamaz. Conclusion . Expressed microecological violations in the large intestine in children with higher levels of bac- teria are conditionally risk factor reeks of infectious complications in the postoperative period and require are complex tools to assist in eliminatsii.s given antibiotic resistance of bacteria.