PURPOSE: This study aims to correlate optical coherence tomography angiography (OCTA)-based retinal microvasculature changes in cases of full-thickness macular hole (FTMH) before and after vitreoretinal surgery and its relation to patient’s visual recovery. METHODS: Data of 31 eyes with FTMH were evaluated preoperatively and post-operatively at 6, 12, and 24 weeks for OCTA parameters and compared. RESULTS: 93.55% eyes (29 eyes) showed improvement in best-corrected visual acuity at 24 weeks. The mean foveal avascular zone (FAZ) significantly reduced from 0.41 ± 0.13 mm2 (preoperatively) to 0.25 ± 0.01 mm2 (postoperatively at 24 weeks). Mean preoperative vessel density (VD) in the superficial vascular plexus (SVP) progressively improved to 24.2% ± 2.2%, 25.2% ± 2.1% and 25.8% ± 2.3% at 6, 12, and 24 weeks respectively from 24.4% ± 2.1% preoperatively (P = 0.0, F = 5.1). The mean VD of foveal region in the SVP significantly improved (P < 0.0, F = 13.9) while that of the parafoveal region did not improve at 24 weeks (P = 0.3, F = 1.2) when compared with its preoperative status. The mean preoperative VD in the deep vascular plexus (DVP) was 20.2% ± 2.6%. It significantly improved at 6, 12, and 24 weeks (20.3% ± 2.4%, 21.8% ± 2.3% and 22.1% ± 2.2%, respectively; P = 0.0, F = 6.9). The mean VD of foveal region and parafoveal region in the DVP showed significant improvement when compared with its preoperative status (P < 0.0, F = 39.3, P < 0.0, F = 13.7). CONCLUSION: This study showed reduction in mean FAZ area and improvement in mean VD at SVP and DVP in the macula postoperatively. Routine perioperative OCTA-based documentation of macular vascularity in FTMH may throw a light in cases with anatomico-functional postoperative disparities in future.

Purpose: In cases of eyelid malignancies requiring full thickness excisional biopsy followed by reconstruction of the created defect, the Meibomian glands are lost. Post-operative varying degrees of dry eye disease (DED) are expected in such patients. The aim was to evaluate the objective and subjective statuses of DED in cases of full thickness eyelid reconstruction following excisional biopsy because of malignancies. Methods: This was a cross-sectional pilot study. Objective and subjective dry eye parameters are assessed in cases of full thickness eyelid reconstruction following excisional biopsy because of malignancies in 37 eyes at 6 months post-operative follow-up. Analysis of variance and Chi square test were used for statistical analysis. Results: When compared with fellow eye, all the parameters were found to be statistically significant (P < 0.0). Subjective assessment of dry eye by ocular surface disease index (OSDI) scoring did not corroborate with the objective data (p 0.00). Lower eyelid reconstruction showed a minimum number of dry eye cases (P > 0.05). Conclusion: Prevalence of post-operative dry eye is more with increasing percentage of full thickness upper eyelid reconstruction. Disparity was found between objective and subjective parameters of dry eye in patients requiring varying percentages of upper eyelid reconstruction because of malignancies.