Electroencephalograms (EEG)-based technology for recognizing emotions has attracted a lot of interest lately. However, there is still work to be done on the efficient fusion of different temporal and spatial features of EEG signals to improve performance in emotion recognition. Therefore, this study suggests a new deep learning architecture that combines a time–frequency convolutional neural network (TFCNN), a bidirectional gated recurrent unit (BiGRU), and a self-attention mechanism (SAM) to categorize emotions based on EEG signals and automatically extract features. The first step is to use the continuous wavelet transform (CWT), which responds more readily to temporal frequency variations within EEG recordings, as a layer inside the convolutional layers, to create 2D scalogram images from EEG signals for time series and spatial representation learning. Second, to encode more discriminative features representing emotions, two-dimensional (2D)-CNN, BiGRU, and SAM are trained on these scalograms simultaneously to capture the appropriate information from spatial, local, temporal, and global aspects. Finally, EEG signals are categorized into several emotional states. This network can learn the temporal dependencies of EEG emotion signals with BiGRU, extract local spatial features with TFCNN, and improve recognition accuracy with SAM, which is applied to explore global signal correlations by reassigning weights to emotion features. Using the SEED and GAMEEMO datasets, the suggested strategy was evaluated on three different classification tasks: one with two target classes (positive and negative), one with three target classes (positive, neutral, and negative), and one with four target classes (boring, calm, horror, and funny). Based on the comprehensive results of the experiments, the suggested approach achieved a 93.1 https://www.mathworks.com/matlabcentral/fileexchange/165126-tfcnn-bigru

Emotion recognition based on Electroencephalography (EEG) signals has garnered significant attention across diverse domains including healthcare, education, information sharing, and gaming, among others. Despite its potential, the absence of a standardized feature set poses a challenge in efficiently classifying various emotions. Addressing the issue of high dimensionality, this paper introduces an advanced variant of the Coati Optimization Algorithm (COA), called eCOA for global optimization and selecting the best subset of EEG features for emotion recognition. Specifically, COA suffers from local optima and imbalanced exploitation abilities as other metaheuristic methods. The proposed eCOA incorporates the COA and RUNge Kutta Optimizer (RUN) algorithms. The Scale Factor (SF) and Enhanced Solution Quality (ESQ) mechanism from RUN are applied to resolve the raised shortcomings of COA. The proposed eCOA algorithm has been extensively evaluated using the CEC’22 test suite and two EEG emotion recognition datasets, DEAP and DREAMER. Furthermore, the eCOA is applied for binary and multi-class classification of emotions in the dimensions of valence, arousal, and dominance using a multi-layer perceptron neural network (MLPNN). The experimental results revealed that the eCOA algorithm has more powerful search capabilities than the original COA and seven well-known counterpart methods related to statistical, convergence, and diversity measures. Furthermore, eCOA can efficiently support feature selection to find the best EEG features to maximize performance on four quadratic emotion classification problems compared to the methods of its counterparts. The suggested method obtains a classification accuracy of 85.17% and 95.21% in the binary classification of low and high arousal emotions in two public datasets: DEAP and DREAMER, respectively, which are 5.58% and 8.98% superior to existing approaches working on the same datasets for different subjects, respectively.

Peripheral neuropathy is a common adverse effect associated with the use of a group of chemotherapeutic agents including paclitaxel (PTX) which negatively affect the quality of life of cancer survivors. In addition, it is considered as a dose-limiting side effect that hinder completion of appropriate chemotherapy regimen. In spite of 27 years of research in mechanisms of PTX neuropathy, there is no approved therapy for prevention of PTX-induced peripheral neuropathy (PIPN). Thus, there is a continuous need to characterize the possible mechanisms associates with PIPN in order to find appropriate targeted therapy for this clinical problem. In this review, most of the recent findings of the cellular targets implicated in PIPN are summarized.

Affective computing, a subcategory of artificial intelligence, detects, processes, interprets, and mimics human emotions. Thanks to the continued advancement of portable non-invasive human sensor technologies, like brain–computer interfaces (BCI), emotion recognition has piqued the interest of academics from a variety of domains. Facial expressions, speech, behavior (gesture/posture), and physiological signals can all be used to identify human emotions. However, the first three may be ineffectual because people may hide their true emotions consciously or unconsciously (so-called social masking). Physiological signals can provide more accurate and objective emotion recognition. Electroencephalogram (EEG) signals respond in real time and are more sensitive to changes in affective states than peripheral neurophysiological signals. Thus, EEG signals can reveal important features of emotional states. Recently, several EEG-based BCI emotion recognition techniques have been developed. In addition, rapid advances in machine and deep learning have enabled machines or computers to understand, recognize, and analyze emotions. This study reviews emotion recognition methods that rely on multi-channel EEG signal-based BCIs and provides an overview of what has been accomplished in this area. It also provides an overview of the datasets and methods used to elicit emotional states. According to the usual emotional recognition pathway, we review various EEG feature extraction, feature selection/reduction, machine learning methods (e.g., k-nearest neighbor), support vector machine, decision tree, artificial neural network, random forest, and naive Bayes) and deep learning methods (e.g., convolutional and recurrent neural networks with long short term memory). In addition, EEG rhythms that are strongly linked to emotions as well as the relationship between distinct brain areas and emotions are discussed. We also discuss several human emotion recognition studies, published between 2015 and 2021, that use EEG data and compare different machine and deep learning algorithms. Finally, this review suggests several challenges and future research directions in the recognition and classification of human emotional states using EEG.

In this paper, we present an approach for the anticipation of electroencephalography (EEG) seizures using different families of wavelet transform. Different signal attributes are investigated to anticipate the seizure onset based on the wavelet transform. These attributes comprise amplitude, local mean, local median, local variance, derivative, and entropy of the wavelet-transformed signals. Different wavelet families are considered including Haar, Daubechies (db4, and db8), Symlets (Sym4), and Coiflets (Coif4) wavelets. The seizure prediction process is intended to be simple to be applied on a mobile application accompanying the patient to give him alerts of possible incoming seizures. The proposed approach is performed on long-term EEG recordings from the available CHB-MIT scalp dataset. It gives the best results in comparison with the other previous algorithms. It achieves a high sensitivity of 100% with Daubechies wavelet transform (db4) in addition to a low average False Prediction Rate (FPR) of 0.0818 h−1 and a high average Prediction Time (PT) of 38.1676 min. Therefore, it can help specialists for the prediction of epileptic seizures as early as possible.

A hybrid novel meta-heuristic optimization algorithm termed Whale Optimization Algorithm (WOA) and Support Vector Machines (SVMs) to obtain an Electroencephalogram (EEG) classification approach was proposed here in this paper for automatic seizure detection termed WOA-SVM. In the proposed approach, the Discrete Wavelet Transform (DWT) was applied to extract the main features and then decompose it into four level of decomposition tree. Furthermore, WOA was utilized to find the more significant feature subset of EEG from a larger feature pool as well as to enhance the parameters of SVM classifier. In order to detect epileptic, SVM with a Radial Basis kernel Function (RBF) was applied. Eventually, the proposed WOA-SVM approach is able to enhance the diagnosis of epilepsy as revealed from the statistical results with accuracy 100% for normal subject data versus epileptic data.

Anomaly detection is a very vital area in medical signal and image processing due to its importance in automatic diagnosis. This paper presents three efficient anomaly detection approaches for applications related to Electroencephalogram (EEG) signal processing and retinal image processing. The first approach depends on the utilization of Scale-Invariant Feature Transform (SIFT) for automatic seizure detection. The second one is based on the utilization of digital filters in a statistical framework for seizure prediction. Finally, an automated Diabetic Retinopathy (DR) diagnosis approach is presented based on the segmentation and detection of anomalous objects from retinal images. The presented simulation results reveal the success of the proposed techniques towards automated medical diagnosis.

Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of brain cells. Hence, seizure identification has great importance in clinical therapy of epileptic patients. Electroencephalogram (EEG) is one of the main biomarker that can measure voltage fluctuations of the brain and EEG data analysis helps to investigate the patient with epilepsy syndrome as epilepsy leaves their signature in EEG signals. In this paper, the Discrete Wavelet Transform (DWT) is applied to EEG signals to pre-processing, decompose it till the 4th level of decomposition tree.Various features like Entropy, Min, Max, Mean, Median, Standard deviation, Variance, Skewness, Energy and Relative Wave Energy (RWE) were computed in terms of detailed coefficients and the approximation coefficients of the last decomposition level.Then, the extracted features are evaluated by three modern machine-learning classifiers such as Radial Basis Function based Support Vector Machine (SVMRBF), k-Nearest Neighbor (KNN) and Naive Bayes (NB). The experimental results demonstrate that the highest classification accuracy (100\%) for normal subject data versus epileptic data is obtained by SVMRBF. the corresponding accuracy between normal subject data and epileptic data using KNN and NB is obtained as 99.50\% and 99\% for the eyes open and eyes closed conditions, respectively. The similar accuracies, while comparing the interictal and ictal data, are obtained as 99\%, 97.50\% and 98.50\% using the SVMRBF, KNN and NB classifiers, respectively. These accuracies are quite higher than earlier results published.

In this paper, a hybrid classification model using Grasshopper Optimization Algorithm (GOA) and support vector machines (SVMs) for automatic seizure detection in EEG is proposed called GOA-SVM approach. Various parameters were extracted and employed as the features to train the SVM with radial basis function (RBF) kernel function (SVM-RBF) classifiers. GOA was used for selecting the effective feature subset and the optimal settings of SVMs parameters in order to obtain a successful EEG classification. The experimental results confirmed that the proposed GOA-SVM approach, able to detect epileptic and could thus further enhance the diagnosis of epilepsy with accuracy 100% for normal subject data versus epileptic data. Furthermore, the proposed approach has been compared with Particle Swarm Optimization (PSO) with support vector machines (PSO-SVMs) and SVM using RBF kernel function. The computational results reveal that GOA-SVM approach achieved better classification accuracy outperforms both PSO-SVM and typical SVMs.

Diabetes mellitus can be considered as a state of chronic inflammation and oxidative stress.Excessive oxidative stress is implicated in the pathogenesis of diabetic complications.Heme oxygenase-1 is an antioxidant enzyme that is upregulated in response to a variety of insults as a protective mechanism.Resveratrol (RSV) is a polyphenol that exhibits promising pharmacological effects in a variety of disease models.In this study, we investigated the role of RSV in prevention of early pathological changes in the diabetic heart as well as the role of hemeoxygenase-1 in this regard.To achieve this aim, diabetes was induced by ip injection of streptozotocin (50 mg/kg).Rats were divided into 5 experimental groups; normal control (CTR), diabetic control (DM), diabetic rats treated with RSV (DM+RSV); 10 mg/kg) in drinking water, diabetic rats treated with a combination of RSV and an HO-1 inhibitor, Zinc protoporphyrin (ZnPP), (DM + RSV+ZnPP); 10 µmole/Kg/week I.P) and diabetic rats treated with ZnPP alone (DM + ZnPP).Induction of diabetes was accompanied by a significant increase in cardiac MDA level and TGF- protein expression as well as a significant reduction in eNOS and HO-1 expression.Chronic treatment with RSV significantly attenuated the abovementioned pathological changes in addition to alleviation of diabetes-induced histopathological alterations.Furthermore, the effect of RSV was diminished when the HO-1 activity was blocked by ZnPP.In conclusion, these results demonstrate the role of HO-1 in mediating RSV protective effects against diabetes-induced early cardiomyopathy.

This paper proposes a hybrid Electroencephalogram (EEG) classification approach based on grey wolf optimizer (GWO) enhanced support vector machines (SVMs) called GWO-SVM approach for automatic seizure detection. In order to decompose EEG into five sub-band components, the discrete wavelet transform (DWT) was utilized to extracted features set. Then, this features are used to train the SVM with radial basis function (RBF) kernel function. Further, GWO was used for selecting the significant feature subset and the optimal parameters of SVM in order to obtain a successful EEG classification. The experimental results proved that the proposed GWO-SVM approach, able to detect epileptic and could thus further enhance the diagnosis of epilepsy with accuracy 100%. Furthermore, the proposed approach has been compared with genetic algorithm (GA) with support vector machines (GA-SVMs) and SVM using RBF kernel function. The computational results reveal that GWO-SVM approach achieved better classification accuracy outperforms both GA-SVM and typical SVMs.

Epilepsy is one of the most common a chronic neurological disorders of the brain that affect millions of the world's populations. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of brain cells. Hence, seizure identification has great importance in clinical therapy of epileptic patients. Electroencephalogram (EEG) is most commonly used in epilepsy detection since it includes precious physiological information of the brain. However, it could be a challenge to detect the subtle but critical changes included in EEG signals. Feature extraction of EEG signals is core trouble on EEG-based brain mapping analysis. This paper will extract ten features from EEG signal based on discrete wavelet transform (DWT) for epilepsy detection. These numerous features will help the classifiers to achieve a good accuracy when utilize to classify EEG signal to detect epilepsy. Subsequently, the results have illustrated that DWT has been adopted to extract various features i.e., Entropy, Min, Max, Mean, Median, Standard deviation, Variance, Skewness, Energy and Relative Wave Energy (RWE).